Výsledky vyhledávání - "W J, Kozumbo"

Human Alveolar and Peritoneal Macrophages Mediate Fungistasis Independently of L-Arginine Oxidation to Nitrite or Nitrate

Autor: Hillel S. Koren, W. J. Kozumbo, Donald L. Granger, M. L. Cameron, J B Weinberg

Publikováno v: American Review of Respiratory Disease. 142:1313-1319

Human alveolar macrophages (HAM) from 28 normal volunteers were found to inhibit replication of Cryptococcus neoformans. Conditions under which fungistasis occurred were different than those required for mouse peritoneal macrophage-mediated fungistas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76cca800012b1c6799456d22710a6a70
https://doi.org/10.1164/ajrccm/142.6_pt_1.1313

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Products of ozonized arachidonic acid potentiate the formation of DNA single strand breaks in cultured human lung cells

Autor: W J, Kozumbo, N M, Hanley, S, Agarwal, M J, Thomas, M C, Madden

Publikováno v: Environmental and molecular mutagenesis. 27(3)

In this study we examined the potential for environmental levels of ozone (03) to degrade arachidonic acid (AA), a polyunsaturated fatty acid abundantly present in the lung, into products that can produce DNA single strand breaks (ssb) in cultured hu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::40da62b5047d5704bb4325c481100a02
https://pubmed.ncbi.nlm.nih.gov/8625954

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Molecular mechanisms involved in T cell activation. I. Evidence for independent signal-transducing pathways in lymphokine production vs proliferation in cloned cytotoxic T lymphocytes

Autor: D T Harris, W J Kozumbo, P Cerutti, J C Cerottini

Publikováno v: The Journal of Immunology. 138:600-605

It is well-established that activated T cells proliferate in response to interleukin 2 (IL 2) and produce various soluble lymphokines such as macrophage-activating factor (MAF) in response to antigen. Prior to investigating the molecular events invol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::07478aed9f60177c4d032097febcf27f
https://doi.org/10.4049/jimmunol.138.2.600

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Molecular mechanisms involved in T cell activation. III. The role of extracellular calcium in antigen-induced lymphokine production and interleukin 2-induced proliferation of cloned cytotoxic T lymphocytes

Autor: D T Harris, W J Kozumbo, J E Testa, P A Cerutti, J C Cerottini

Publikováno v: The Journal of Immunology. 140:921-927

The role that extracellular calcium plays in activating resting cloned cytotoxic T lymphocytes (CTL) to proliferate and to produce lymphokines was examined. In these cells, stimulation with interleukin 2 (IL-2) induced a proliferative response withou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::996cfa8b69fa330684cd4af365c69d36
https://doi.org/10.4049/jimmunol.140.3.921

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Molecular mechanisms involved in T cell activation. II. The phosphatidylinositol signal-transducing mechanism mediates antigen-induced lymphokine production but not interleukin 2-induced proliferation in cloned cytotoxic T lymphocytes

Autor: W J Kozumbo, D T Harris, S Gromkowski, J C Cerottini, P A Cerutti

Publikováno v: The Journal of Immunology. 138:606-612

The phospholipid metabolism of cloned murine cytotoxic T lymphocytes (CTL) was examined under conditions in which the induction of proliferation by interleukin 2 (IL 2) and the stimulated production of lymphokine (macrophage-activating factor (MAF] b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c1f2e5f9b158dc7eaec18b3efc07dbe8
https://doi.org/10.4049/jimmunol.138.2.606

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Phorbol ester-induced formation of clastogenic factor from human monocytes

Autor: I Emerit, W J Kozumbo, A Jörg, Peter Cerutti, Dominique Muehlematter

Publikováno v: Carcinogenesis. 8:521-526

Phorbol-12-myristate-13-acetate (PMA) acts as a tumor promoter on mouse skin. It induces inflammation and leukocyte-mediated clastogenicity which appears to be related to rapid changes in lipid metabolism. To identify lipids possessing clastogenic an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94fba888a402fc126a9d43b74f279db
https://doi.org/10.1093/carcin/8.4.521

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Autor: W J, Kozumbo, D T, Harris, S, Gromkowski, J C, Cerottini, P A, Cerutti

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 138(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5f0b9ad1b007737b018016988c0adf2e
https://pubmed.ncbi.nlm.nih.gov/3540124

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Inhibition by 2(3)-tert-butyl-4-hydroxyanisole and other antioxidants of epidermal ornithine decarboxylase activity induced by 12-O-tetradecanoylphorbol-13-acetate

Autor: W J, Kozumbo, J L, Seed, T W, Kensler

Publikováno v: Cancer research. 43(6)

The relationship between reactive oxygen and/or free radical species and tumor promotion was evaluated by investigating the inhibitory effects of 2(3)-tert-butyl-4-hydroxyanisole (BHA) and other antioxidants on the induction of ornithine decarboxylas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dca98752b8bb95b7e3ae9f6cabb264e1
https://pubmed.ncbi.nlm.nih.gov/6850576

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Mechanism of cyclosporin A-induced immunosuppression. Cyclosporin A inhibits receptor-mediated and non-receptor-mediated lymphokine production as well as interleukin-2-induced proliferation in cloned T lymphocytes

Autor: D T, Harris, W J, Kozumbo, P A, Cerutti, J C, Cerottini

Publikováno v: Cellular immunology. 109(1)

The effects of cyclosporin A (CyA) on the activation processes of cloned murine cytotoxic T lymphocytes (CTL) have been examined. With the use of Day 7 resting cloned CTL it was possible to separate the functions of lymphokine production (macrophage-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50e26fadd08b4dada9040dc18d0f1ff2
https://pubmed.ncbi.nlm.nih.gov/3115596

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