Zobrazeno 1 - 10
of 119
pro vyhledávání: '"W J, Jusko"'
Publikováno v:
Pediatric Transplantation. 3:126-130
The area under the time-plasma concentration curve (AUC) was measured for prednisolone (the major active metabolite of prednisone) after ingestion of 15 mg of prednisone (phase 1) and again after 3 d of oral diltiazem (180 mg/d) followed by the same
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cecd4e016d883cc34002d3bf31eccce
https://doi.org/10.1034/j.1399-3046.1999.00027.x
https://doi.org/10.1034/j.1399-3046.1999.00027.x
Autor:
D E, Mager, W J, Jusko
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 28(6)
Drugs that bind with high affinity and to a significant extent (relative to dose) to a pharmacologic target such as an enzyme, receptor, or transporter may exhibit nonlinear pharmacokinetic (PK) behavior. Processes such as receptor-mediated endocytos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d48e3a547db844ce55c90b2de621deb4
https://pubmed.ncbi.nlm.nih.gov/11999290
https://pubmed.ncbi.nlm.nih.gov/11999290
Publikováno v:
Journal of clinical pharmacology. 38(12)
A double-blind, placebo-controlled, parallel-group, ascending, multiple-dose study was completed in 45 healthy male volunteers to assess the maximum tolerated dose, pharmacokinetics, and pharmacodynamics of BMS-187745, a squalene synthase inhibitor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f9bb1f126f5ded57b9215ffb69352495
https://pubmed.ncbi.nlm.nih.gov/11301563
https://pubmed.ncbi.nlm.nih.gov/11301563
Autor:
J V, Gobburu, W J, Jusko
Publikováno v:
Advanced drug delivery reviews. 46(1-3)
The role of drug delivery in controlling indirect pharmacodynamic responses was assessed via computer simulations and literature review. Simulations of responses related to basic indirect response mechanisms were performed for various drug input rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::61f8ef44af95b68e9b005e4b3b09c5a6
https://pubmed.ncbi.nlm.nih.gov/11259832
https://pubmed.ncbi.nlm.nih.gov/11259832
Autor:
W, Krzyzanski, W J, Jusko
Publikováno v:
Journal of pharmacokinetics and pharmacodynamics. 28(1)
Basic indirect response models where drug alters the production (kin) of the response variable (R) based on the Hill function previously assumed one-compartment distribution of the response variable and simple first-order loss (kout) of R. These mode
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::191cd04d05bfe835acd41b21de5f1abf
https://pubmed.ncbi.nlm.nih.gov/11253614
https://pubmed.ncbi.nlm.nih.gov/11253614
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 27(6)
A physiologic pharmacodynamic model was developed to jointly characterize the effects of corticosteroid treatment on adrenal suppression and T-helper cell trafficking during single and multiple dosing in asthmatic patients. Methylprednisolone (MP), c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f2b937451a856eb040f5a107cd933714
https://pubmed.ncbi.nlm.nih.gov/11153446
https://pubmed.ncbi.nlm.nih.gov/11153446
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 27(5)
Basic indirect pharmacodynamic models for agents which alter the generation of natural cells based on a life-span concept are introduced. It is assumed that cells (R) are produced at a constant rate (kin), survive for a specific duration TR, and then
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a083db78f9f761e31972eefb6cfdb400
https://pubmed.ncbi.nlm.nih.gov/10948694
https://pubmed.ncbi.nlm.nih.gov/10948694
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 292(2)
The pharmacokinetics and pharmacodynamics (PK/PD) of a humanized anti-Factor IX IgG1 monoclonal antibody (SB 249417, FIX mAb) were studied in Cynomolgus monkeys. Single i.v. bolus doses of 1, 3, or 10 mg/kg of FIX mAb were administered. The total FIX
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5a51fd73d0016675e0b344bb67d4d285
https://pubmed.ncbi.nlm.nih.gov/10640322
https://pubmed.ncbi.nlm.nih.gov/10640322
Autor:
A A, Fasanmade, W J, Jusko
Publikováno v:
Biopharmaceuticsdrug disposition. 20(5)
Glucocorticoids have diverse effects on various components of the immune system and assessment of such activities in vivo often involves complex techniques and numerous animals. We developed a whole blood technique for determining proliferation rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::503266440667da5b79e0a35603e0e860
https://pubmed.ncbi.nlm.nih.gov/10594870
https://pubmed.ncbi.nlm.nih.gov/10594870
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 27(1)
Prednisolone (Pred) and sirolimus (SIR) are immunosuppressive compounds acting through different mechanisms with moderate synergism found in vitro. Both drugs are metabolized partly by CYP3A enzymes. After i.v. administration of placebo, Pred (5 mg/k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd1b87d198016f0e383b4f2db3838a6f
https://pubmed.ncbi.nlm.nih.gov/10533695
https://pubmed.ncbi.nlm.nih.gov/10533695