Zobrazeno 1 - 10
of 50
pro vyhledávání: '"W J, Hrushesky"'
Publikováno v:
International journal of cancer. 88(3)
Fluoropyrimidines induce cytotoxicity, in part, by inhibiting the proliferation-coordinated enzyme thymidylate synthase (TS), which is essential for DNA synthesis. Tumor TS levels are clinically predictive of post-surgical tumor recurrence and of res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05bebc1d04130e1d3c8c4e7e32ad34e9
https://pubmed.ncbi.nlm.nih.gov/11054680
https://pubmed.ncbi.nlm.nih.gov/11054680
Publikováno v:
International journal of cancer. 83(3)
To understand whether mammalian circadian time structure measurably affects the host-cancer balance, we studied tumor-take frequency after s.c. tumor cell inoculation and the number of pulmonary tumor nodules after i.v. tumor cell injections at each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::583741c8e146b2d8aabdd8afe9be2114
https://pubmed.ncbi.nlm.nih.gov/10495429
https://pubmed.ncbi.nlm.nih.gov/10495429
Publikováno v:
Experimental hematology. 26(6)
Circadian differences in the susceptibility of the marrow to the effects of radiation, myelotoxic drugs, and growth factors suggest that hematopoietic processes vary significant throughout each day. One mechanism possibly responsible for the differin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::56948f619398072d85a3f09734ca4e59
https://pubmed.ncbi.nlm.nih.gov/9620286
https://pubmed.ncbi.nlm.nih.gov/9620286
Autor:
A A, Hagen, W J, Hrushesky
Publikováno v:
American journal of surgery. 175(3)
This is a critical review of the growing body of data, 32 retrospective studies of the outcomes of 9,665 women published since 1989, relevant to the possibility that the timing of primary breast cancer resection within the menstrual cycle impacts bre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::69107d755048e1964f49f56a529100c3
https://pubmed.ncbi.nlm.nih.gov/9560131
https://pubmed.ncbi.nlm.nih.gov/9560131
Autor:
W J, Hrushesky, P A, Wood
Publikováno v:
The Journal of infectious diseases. 175(5)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ecc542c1860440e5d58716db569f98f8
https://pubmed.ncbi.nlm.nih.gov/8896506
https://pubmed.ncbi.nlm.nih.gov/8896506
Autor:
W J, Hrushesky
Publikováno v:
Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer. 140
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b3a73abc9d54721654d099c7329b8663
https://pubmed.ncbi.nlm.nih.gov/8787069
https://pubmed.ncbi.nlm.nih.gov/8787069
Publikováno v:
Cancer. 75(10)
Continuous infusion of 2'-deoxy-5-fluorouridine (FUdR) has shown promise in its activity against metastatic renal cell carcinoma. Its side-effect profile is dominated by gastrointestinal toxicity; there are no known adverse pulmonary reactions. To th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a54edf407ba25648a97108859dead17f
https://pubmed.ncbi.nlm.nih.gov/7736401
https://pubmed.ncbi.nlm.nih.gov/7736401
Autor:
P A, Wood, W J, Hrushesky
Publikováno v:
The Journal of infusional chemotherapy. 5(4)
Temporal coordination of biologic processes with an approximately 24-hour cycle (circadian) is ubiquitous throughout the animal and plant kingdoms. In each organism studied, the capability to keep biologic time is an inherited characteristic. These b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::51bbd26b4bcd808e86aa7c729350442f
https://pubmed.ncbi.nlm.nih.gov/8934723
https://pubmed.ncbi.nlm.nih.gov/8934723
Autor:
W J, Hrushesky
Publikováno v:
The Journal of infusional chemotherapy. 5(1)
Cicadian variation in drug metabolism and tissue sensitivity to drugs impacts their activity and toxicity. A growing body of data suggests that therapy may be improved and toxicity reduced, by administering antineoplastic agents at carefully selected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a625261554c4cc0df1ec3bc66f45f840
https://pubmed.ncbi.nlm.nih.gov/7634176
https://pubmed.ncbi.nlm.nih.gov/7634176
Autor:
W J, Hrushesky
Publikováno v:
Cancer. 74
Without organized clinical trials, we are doomed to repeat our mistakes endlessly. There are many genuine conflicts of interest intrinsic to clinical research. Some of these arise from the necessity of admitting that we as physicians do not know the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7a203ac0126b123a375e08820bd4e38
https://pubmed.ncbi.nlm.nih.gov/7954290
https://pubmed.ncbi.nlm.nih.gov/7954290