Zobrazeno 1 - 10
of 217
pro vyhledávání: '"W J, Hall"'
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
Abstract Highly sensitive DNA sequencing techniques have allowed the discovery of large numbers of somatic mutations in normal tissues. Some mutations confer a competitive advantage over wild-type cells, generating expanding clones that spread throug
Externí odkaz:
https://doaj.org/article/5502ff1cc7eb4d59948e2b563cac925f
Publikováno v:
Royal Society Open Science, Vol 8, Iss 5 (2021)
A single population of progenitor cells maintains many epithelial tissues. Transgenic mouse cell tracking has frequently been used to study the growth dynamics of competing clones in these tissues. A mathematical model (the ‘single-progenitor model
Externí odkaz:
https://doaj.org/article/296806f45a104ed895bd80356c9cd314
Autor:
Emilie Abby, Stefan C. Dentro, Michael W. J. Hall, Joanna C. Fowler, Swee Hoe Ong, Roshan Sood, Albert Herms, Gabriel Piedrafita, Irina Abnizova, Christian W. Siebel, Moritz Gerstung, Benjamin A. Hall, Philip H. Jones
NOTCH1 mutant clones occupy the majority of normal human esophagus by middle age but are comparatively rare in esophageal cancers, suggesting NOTCH1 mutations drive clonal expansion but impede carcinogenesis. Here we test this hypothesis. Sequencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e3995a6ea6c8197c93dc9b47a0c6967
https://www.repository.cam.ac.uk/handle/1810/346529
https://www.repository.cam.ac.uk/handle/1810/346529
Autor:
Charlotte King, Joanna C. Fowler, Jonas Koeppel, Kourosh Saeb-Parsy, Swee Hoe Ong, Moritz Gerstung, Benjamin A. Hall, Eleanor Earp, Amer Durrani, Krishnaa Mahububani, Kate Fife, David Shorthouse, Stefan C. Dentro, Christopher J. Bryant, Sood R, Michael W. J. Hall, Philip H. Jones, Amit Roshan, Edward Rytina, Doreen Milne, David Fernandez-Antoran
Publikováno v:
Cancer Discovery. 11:340-361
Skin cancer risk varies substantially across the body, yet how this relates to the mutations found in normal skin is unknown. Here we mapped mutant clones in skin from high- and low-risk sites. The density of mutations varied by location. The prevale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f73fbf1e41c2f2896010a76b8b12e70
https://doi.org/10.1158/2159-8290.cd-20-1092
https://doi.org/10.1158/2159-8290.cd-20-1092
Autor:
Swee Hoe Ong, Joanna C. Fowler, Charlotte King, Michael W. J. Hall, Moritz Gerstung, Bartomeu Colom, Philip H. Jones, Gabriel Piedrafita, Sood R, Agnieszka Wabik, Stefan C. Dentro, Maria P. Alcolea, Inigo Martincorena, Benjamin A. Hall, Albert Herms
Publikováno v:
Nature Genetics. 52:604-614
During aging, progenitor cells acquire mutations, which may generate clones that colonize the surrounding tissue. By middle age, normal human tissues, including the esophageal epithelium (EE), become a patchwork of mutant clones. Despite their releva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54852df30674d4ce50474c15d4017ca5
https://doi.org/10.1038/s41588-020-0624-3
https://doi.org/10.1038/s41588-020-0624-3
Publikováno v:
Journal of the Royal Society Interface
During ageing, normal epithelial tissues progressively accumulate clones carrying mutations that increase mutant cell fitness above that of wild-type cells. Such mutants spread widely through the tissues, yet despite this cellular homeostasis and fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c8457a94f1183293264f17205583d5f8
https://pubmed.ncbi.nlm.nih.gov/34637643
https://pubmed.ncbi.nlm.nih.gov/34637643
Publikováno v:
Journal of The Royal Society Interface. 18
During ageing, normal epithelial tissues progressively accumulate clones carrying mutations that increase mutant cell fitness above that of wild-type cells. Such mutants spread widely through the tissues, yet despite this cellular homeostasis and fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0290cb3ff67c84061b93b33765c16f2f
https://doi.org/10.1098/rsif.2021.0607
https://doi.org/10.1098/rsif.2021.0607
Publikováno v:
Royal Society Open Science, Vol 8, Iss 5 (2021)
Royal Society Open Science
Royal Society Open Science
Funder: Wellcome Trust; Id: http://dx.doi.org/10.13039/100004440
Funder: Clare College
Funder: MRC Cancer unit
Funder: Medical Research Council (MRC)
A single population of progenitor cells maintains many epithelial tissues. Trans
Funder: Clare College
Funder: MRC Cancer unit
Funder: Medical Research Council (MRC)
A single population of progenitor cells maintains many epithelial tissues. Trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c698942b570ee79e57cf1197941e0c22
Autor:
Stefan C. Dentro, Charlotte King, Joanna C. Fowler, Albert Herms, Bartomeu Colom, Maria P. Alcolea, Krishnaa T. Mahbubani, Kourosh Saeb-Parsy, Benjamin A. Hall, David Fernandez-Antoran, Moritz Gerstung, Sood R, Michael W. J. Hall, Philip H. Jones, Gabriel Piedrafita, Swee Hoe Ong
Publikováno v:
Nature. 598(7881)
Human epithelial tissues accumulate cancer-driver mutations with age1–9, yet tumour formation remains rare. The positive selection of these mutations suggests that they alter the behaviour and fitness of proliferating cells10–12. Thus, normal adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903d67dbeb9b3d7387c83f7a215ab506
https://pubmed.ncbi.nlm.nih.gov/35015999
https://pubmed.ncbi.nlm.nih.gov/35015999
The recent development of highly sensitive DNA sequencing techniques has detected large numbers of missense mutations of genes, including NOTCH1 and 2, in ageing normal tissues. Driver mutations persist and propagate in the tissue through a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4916d910e91d62b96366ede94275712