Zobrazeno 1 - 10
of 18
pro vyhledávání: '"W J, Grimes"'
A human monoclonal antimelanoma single-chain Fv antibody derived from tumor-infiltrating lymphocytes
Publikováno v:
Cancer research. 55(16)
With the development of recombinant DNA technology, it has become feasible to clone, construct, and express fully human immunoglobulin molecules. Here we report a novel methodology to make human antitumor single-chain Fv (scFv) antibodies from tumor-
Autor:
Lance A. Liotta, Danny R. Welch, William G. Stetler-Stevenson, Mary J.C. Hendrix, E. A. Seftor, W. J. Grimes, Richard E. B. Seftor
Publikováno v:
Melanoma research. 1(1)
A 48 h pretreatment of two malignant and invasive human melanoma cell lines with either swainsonine (an inhibitor of Golgi alpha-mannosidase II) or deoxymannojirimycin (a Golgi alpha-mannosidase I inhibitor) resulted in a dose-dependent decrease in t
Publikováno v:
The Journal of Immunology. 142:2133-2139
Lymphokine-activated killer (LAK) cells are cytotoxic for a variety of autologous and allogeneic tumor cells as well as modified autologous cells. It is assumed that LAK cells lyse their targets solely by direct cell to cell contact, possibly involvi
Publikováno v:
The Journal of Immunology. 141:4418-4424
Lymphokine activated killer cells (LAK) have been demonstrated to be cytotoxic for a variety of tumor-derived cells. Little is known of the nature of the cell surface molecules that mediate LAK cell-target cell interactions. Reported here are studies
Autor:
D R Anderson, W J Grimes
Publikováno v:
Journal of Biological Chemistry. 257:14858-14864
Mouse myeloma immunoglobulin IgM heavy chains were cleaved with cyanogen bromide into nine peptide fragments, four of which contain asparagine-linked sites of glycosylation. Three of these glycopeptides contain a single site located at asparagines 17
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 142(6)
Lymphokine-activated killer (LAK) cells are cytotoxic for a variety of autologous and allogeneic tumor cells as well as modified autologous cells. It is assumed that LAK cells lyse their targets solely by direct cell to cell contact, possibly involvi
Autor:
B S, Litin, W J, Grimes
Publikováno v:
Cancer research. 43(5)
We have identified previously a group of sialoglycoproteins with an apparent molecular weight of 110,000, which appear homogeneous by sodium dodecyl sulfate:polyacrylamide gel electrophoresis but exhibit isoelectric point heterogeneity by two-dimensi
Publikováno v:
Cancer research. 35(2)
The ability of suspensions of BALB/c cells to catalyze the incorporation of nucleotide sugars into complex polysaccharides has been compared. These cells have previously been characterized for concanavalin A-induced agglutinability, tumorigenicity, a
Autor:
B S, Litin, W J, Grimes
Publikováno v:
Cancer research. 39(7 Pt 1)
We have compared cell surface proteins and glycoproteins from normal and transformed cells by two-dimensional electrophoresis. The tumor lines studied include viral and spontaneous transformants which cause tumors that either regress, or grow progres
Autor:
D R, Anderson, W J, Grimes
Publikováno v:
The Journal of biological chemistry. 257(24)
Mouse myeloma immunoglobulin IgM heavy chains were cleaved with cyanogen bromide into nine peptide fragments, four of which contain asparagine-linked sites of glycosylation. Three of these glycopeptides contain a single site located at asparagines 17