A genome-wide association meta-analysis identifies new childhood obesity loci

Autor: Craig E. Pennell, Chris Power, Johannes Hebebrand, David Meyre, Jean Dallongeville, Pma Sleiman, Mark I. McCarthy, Joel N. Hirschhorn, Nicholas J. Timpson, Nicole M. Warrington, Rjp van der Valk, Karani Santhanakrishnan Vimaleswaran, A Pouta, Mònica Guxens, Mariona Bustamante, Luis A. Moreno, M-R Jarvelin, Fredrick R. Schumacher, Aline Meirhaeghe, Charlotte E. Neville, Beatriz Valcarcel, Eleanor Wheeler, Hakon Hakonarson, Stephen O'Rahilly, D. S. Postma, Albert Hofman, Fernando Rivadeneira, Johan G. Eriksson, Hans Bisgaard, George McMahon, Vwv Jaddoe, I. S. Farooqi, Shikta Das, Diane J. Berry, Eskil Kreiner-Møller, Mohamed T. Hassanein, J. C. de Jongste, Joachim Heinrich, Olli T. Raitakari, Jessica L. Buxton, Aarno Palotie, W. J. Gauderman, Paul Elliott, C. Lecoeur, Reedik Mägi, Elina Hyppönen, C M van Duijn, B. St Pourcain, Frank D. Gilliland, Susan M. Ring, John P. Kemp, Rany M. Salem, Lyle J. Palmer, Terho Lehtimäki, Philippe Froguel, Ivonne Jarick, Cag Boreham, Elisabeth Thiering, Dorret I. Boomsma, Sfa Grant, A.-L. Hartikainen, André Scherag, Panagiotis Deloukas, Claus Holst, Jianhua Zhao, André G. Uitterlinden, Robert I. Berkowitz, Cecilia M. Lindgren, Tia Sorensen, Aif Blakemore, Mingyao Li, George Davey Smith, Dennis O. Mook-Kanamori, H R Taal, David M. Evans, Diana L. Cousminer, Matthew W. Gillman, Jonathan P. Bradfield, E. Widen, Anke Hinney, Inês Barroso

Publikováno v: Nature Genetics, 44(5), 526-531e1. Nature Publishing Group
Nature genetics, vol 44, iss 5
Nature Genetics, 44(5), 526-+. Nature Publishing Group
Nature Genetics; Vol 44
Nature genetics
Nature Genetics, 44(5), 526-532. Nature Publishing Group
Ожирение и метаболизм, Vol 9, Iss 1 (2012)
Bradfield, J P, Taal, H R, Timpson, N J, Scherag, A, Lecoeur, C, Warrington, N M, Hypponen, E, Holst, C, Valcarcel, B, Thiering, E, Salem, R M, Schumacher, F R, Cousminer, D L, Sleiman, P M A, Zhao, J, Berkowitz, R I, Vimaleswaran, K S, Jarick, I, Pennell, C E, Evans, D M, St Pourcain, B, Berry, D J, Mook-Kanamori, D O, Hofman, A, Rivadeneira, F, Uitterlinden, A G, van Duijn, C M, van der Valk, R J P, de Jongste, J C, Postma, D S, Boomsma, D I, Gauderman, W J, Hassanein, M T, Lindgren, C M, Mägi, R, Boreham, C A G, Neville, C E, Moreno, L A, Elliott, P, Pouta, A, Hartikainen, A-L, Li, M, Raitakari, O, Lehtimäki, T, Eriksson, J G, Palotie, A, Dallongeville, J, Das, S, Deloukas, P, McMahon, G, Ring, S M, Kemp, J P, Buxton, J L, Blakemore, A I F, Bustamante, M, Guxens, M, Hirschhorn, J N, Gillman, M W, Kreiner-Møller, E, Bisgaard, H, Gilliland, F D, Heinrich, J, Wheeler, E, Barroso, I, O'Rahilly, S, Meirhaeghe, A, Sørensen, T I A, Power, C, Palmer, L J, Hinney, A, Widen, E, Farooqi, I S, McCarthy, M I, Froguel, P, Meyre, D, Hebebrand, J, Järvelin, M J, Jaddoe, V W V, Smith, G D, Hakonarson, H & Grant, S F A 2012, ' A genome-wide association meta-analysis identifies new childhood obesity loci ', Nature Genetics, vol. 44, no. 5, pp. 526-532 . https://doi.org/10.1038/ng.2247
Nature Genetics

Multiple genetic variants have been associated with adult obesity and a few with severe obesity in childhood; however, less progress has been made in establishing genetic influences on common early-onset obesity. We performed a North American, Austra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f880f61d6afe73241feeb22a7a0f214a
https://ora.ox.ac.uk/objects/uuid:96f4bbd6-9965-4488-bd10-c99d0e45ba6b

Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children

Autor: W. J. Gauderman, Rob McConnell, Frank D. Gilliland, Talat Islam, John M. Peters, Kiros Berhane, Edward L. Avol

Publikováno v: Thorax. 64:197-202

Background: Because asthma has been associated with exercise and ozone exposure, an association likely mediated by oxidative stress, we hypothesised that glutathione-S-transferase ( GST ) P1 , GSTM1 , exercise and ozone exposure have interrelated eff

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c495d9b9f8c685c801dbcd7e1839f90d
https://doi.org/10.1136/thx.2008.099366

Maternal smoking during pregnancy, environmental tobacco smoke exposure and childhood lung function

Autor: Frank D. Gilliland, John M. Peters, Hita Vora, Rob McConnell, Kiros Berhane, Edward B. Rappaport, Edward L. Avol, W. J. Gauderman

Publikováno v: Thorax. 55:271-276

Background—Exposure to environmental tobacco smoke (ETS) during childhood and in utero exposure to maternal smoking are associated with adverse eVects on lung growth and development. Methods—A study was undertaken of the associations between mate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c99f1901a4d7b41dc089307b0791563
https://doi.org/10.1136/thorax.55.4.271

Family-Based Association Studies

Autor: Duncan Thomas, John S. Witte, W J Gauderman

Publikováno v: JNCI Monographs. 1999:31-37

We review case-control designs for studying gene associations in which relatives of case patients are used as control subjects. These designs have the advantage that they avoid the problem of population stratification that can lead to spurious associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25284c574bec0ee3a80a4947bebd6375
https://doi.org/10.1093/oxfordjournals.jncimonographs.a024223

Air pollution and bronchitic symptoms in Southern California children with asthma

Autor: Frederick Lurmann, Rob McConnell, Duncan C. Thomas, Edward L. Avol, John M. Peters, W. J. Gauderman, Hita Vora, Kiros Berhane, Helene G. Margolis, Stephanie J. London, Frank D. Gilliland

Publikováno v: Scopus-Elsevier
Environmental Health Perspectives

The association of air pollution with the prevalence of chronic lower respiratory tract symptoms among children with a history of asthma or related symptoms was examined in a cross-sectional study. Parents of a total of 3,676 fourth, seventh, and ten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d742736eb04bf23f944f2825111ec8b
https://doi.org/10.1289/ehp.99107757