Zobrazeno 1 - 7
of 7
pro vyhledávání: '"W J, Fairbrother"'
Publikováno v:
Cell. 103(1)
ProIL-1beta is a proinflammatory cytokine that is proteolytically processed to its active form by caspase-1. Upon receipt of a proinflammatory stimulus, an upstream adaptor, RIP2, binds and oligomerizes caspase-1 zymogen, promoting its autoactivation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d2f59b0ed0304e7658c82de92017501
https://pubmed.ncbi.nlm.nih.gov/11051551
https://pubmed.ncbi.nlm.nih.gov/11051551
Autor:
D L, Baly, R, Horuk, D G, Yansura, L C, Simmons, W J, Fairbrother, C, Kotts, C M, Wirth, B L, Gillece-Castro, K, Toy, J, Hesselgesser, D E, Allison
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(9)
Melanoma growth stimulating activity (MGSA) and IL-8 are related chemokines that are potent chemoattractants and activators of neutrophils both in vitro and in vivo. Increasing evidence suggests that these molecules play an important role in inflamma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::128442a257c8d5faf28161d0ba4ae433
https://pubmed.ncbi.nlm.nih.gov/9794430
https://pubmed.ncbi.nlm.nih.gov/9794430
Publikováno v:
Protein science : a publication of the Protein Society. 6(3)
IL-8 dimers have been observed in NMR and X-ray structures of the protein. We have engineered IL-8 monomers by mutations of residues throughout the dimer interface, which introduce hindrance determinants to dimerization. These IL-8 variants are shown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::03e1ee1b41da5589c4da958fe60569a7
https://pubmed.ncbi.nlm.nih.gov/9070442
https://pubmed.ncbi.nlm.nih.gov/9070442
Autor:
W J, Fairbrother, H B, Lowman
Publikováno v:
Methods in enzymology. 287
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8a6313256a5c9f1d9eede9073d5a0902
https://pubmed.ncbi.nlm.nih.gov/9330314
https://pubmed.ncbi.nlm.nih.gov/9330314
Autor:
R S, McDowell, K A, Elias, M S, Stanley, D J, Burdick, J P, Burnier, K S, Chan, W J, Fairbrother, R G, Hammonds, G S, Ingle, N E, Jacobsen, D L, Mortensen, T E, Rawson, W B, Won, R G, Clark, T C, Somers
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 92(24)
Another class of growth hormone (GH) secretagogues has been discovered by altering the backbone structure of a flexible linear GH-releasing peptide (GHRP). In vitro and in vivo characterization confirms these GH secretagogues as the most potent and s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5940b7bac6a0781d7b85eb6382eb704
https://pubmed.ncbi.nlm.nih.gov/7479958
https://pubmed.ncbi.nlm.nih.gov/7479958
Publikováno v:
Biochemistry. 32(9)
Almost complete assignments of the 1H, 15N, and aliphatic 13C resonances of the 62-residue N-terminal DNA-binding domain of GAL4 [GAL4(62)] have been obtained using a combination of two-dimensional homonuclear and two- and three-dimensional double- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d0fd513e669da65e1dfaeeb43216844
https://pubmed.ncbi.nlm.nih.gov/8443156
https://pubmed.ncbi.nlm.nih.gov/8443156
Publikováno v:
Biochemistry. 31(18)
Nearly complete assignment of the aliphatic 1H and 13C resonances of the IIAglc domain of Bacillus subtilis has been achieved using a combination of double- and triple-resonance three-dimensional (3D) NMR experiments. A constant-time 3D triple-resona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::705c44f1877e361edefdbd0cdeae8352
https://pubmed.ncbi.nlm.nih.gov/1581296
https://pubmed.ncbi.nlm.nih.gov/1581296