Zobrazeno 1 - 10
of 24
pro vyhledávání: '"W J, Christ"'
Autor:
Julia Iyasere, Han Chen, Yuhong Guo, W. J. Christ, Jose A. Halperin, Huseyin Aktas, Fred Harbinski, Lia Luus, Amarnath Natarajan, Yun Hua Fan
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:5401-5405
In an effort to generate novel translation initiation inhibitors for cancer therapy, a series of 2'-benzyloxy-5'-substituted-5-benzylidene-thiazolidine-2,4-thione and dione derivatives was synthesized and evaluated for activity in translation initiat
Autor:
Nathan J. Moerke, Gerhard Wagner, Han Chen, Amarnath Natarajan, W. J. Christ, Yun Hua Fan, Jose A. Halperin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:2657-2660
Binding of eIF4E to the cap structure (m(7)GpppN) plays a critical role in mRNA translation. To study the interaction between eIF4E and cap, and to identify small molecule inhibitors of their binding, we synthesized a fluorescent-labeled cap analogue
Autor:
Julia Iyasere, Han Chen, W. J. Christ, Frederick Harbinski, Yuhong Guo, Jose A. Halperin, Huseyin Aktas, Amarnath Natarajan, Yun Hua Fan
Publikováno v:
Journal of medicinal chemistry. 47(8)
A series of substituted 3,3-diphenyl-1,3-dihydro-indol-2-ones was synthesized from the corresponding isatins. The compounds were studied for cell growth inhibition mediated by partial depletion of intracellular Ca2+ stores that leads to phosphorylati
Autor:
Fred Harbinski, Yun Hua Fan, W. J. Christ, Han Chen, Yuhong Guo, Jose A. Halperin, Huseyin Aktas, Amarnath Natarajan, Julia Iyasere
Publikováno v:
Bioorganicmedicinal chemistry letters. 14(10)
Depletion of calcium from the endoplasmic reticulum has shown to affect protein synthesis and cell proliferation. The anticancer effect of troglitazone was reported to be mediated by depletion of intracellular calcium stores resulting in inhibition o
Autor:
T, Kawata, J R, Bristol, D P, Rossignol, J R, Rose, S, Kobayashi, H, Yokohama, A, Ishibashi, W J, Christ, K, Katayama, I, Yamatsu, Y, Kishi
Publikováno v:
British journal of pharmacology. 127(4)
1. The major pathological responses to Gram-negative bacterial sepsis are triggered by endotoxin or lipopolysaccharide. As endotoxin is shed from the bacterial outer membrane, it induces immunological responses that lead to release of a variety of cy
Autor:
R R, Ingalls, B G, Monks, R, Savedra, W J, Christ, R L, Delude, A E, Medvedev, T, Espevik, D T, Golenbock
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(10)
The activation of phagocytes by the lipid A moiety of LPS has been implicated in the pathogenesis of Gram-negative sepsis. While two LPS receptors, CD14 and CD11/CD18, have been associated with cell signaling, details of the LPS signal transduction c
Autor:
T, Kawata, J R, Bristol, J R, Rose, D P, Rossignol, W J, Christ, O, Asano, G R, Dubuc, W E, Gavin, L D, Hawkins, Y, Kishi
Publikováno v:
Progress in clinical and biological research. 392
Lipid As from non-toxic bacteria such as Rhodobacter capsulatus and Rhodobacter sphaeroides have been shown to antagonize the immunostimulatory effects of lipid A and LPS from pathogenic bacteria. We have biologically characterized a series of synthe
Autor:
S C, Wang, D P, Rossignol, W J, Christ, D A, Geller, P D, Freeswick, N L, Thai, G L, Su, R L, Simmons
Publikováno v:
Surgery. 116(2)
Many of the physiologic derangements resulting in septic shock are caused by inflammatory mediators such as nitric oxide (NO) and cytokines produced in response to bacterial endotoxin or, more specifically, lipopolysaccharide. The recent development
Publikováno v:
ChemInform. 21
The linear and proximal benzo-separated derivatives of 8-phenyltheophylline, 1,3-diethyl-8-phenylxanthine, 1,3-dipropylxanthine, 1,3-dibutylxanthine, 3-isobutyl-1-methylxanthine, theophylline, caffeine, and isocaffeine have been synthesized and evalu
Autor:
M. Yonaga, Mikio Taniguchi, W. W. Jun. Mcwhorter, Masaya Nakata, Sung Ho Kang, J. A. Tino, Robert W. Armstrong, Arnold E. Stütz, F. X. Talamas, J. B. White, Won-Hun Ham, Seung Hoon Cheon, H. Fujioka, M. Mizuno, L. D. Hawkins, Haolun Jin, Jean-Marie Beau, Yoshito Kishi, K. Ueda, J. Uenishi, M. J. Martinelli, W. J. Christ
Publikováno v:
ChemInform. 21