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Measurement of sister chromatid exchange induction in intracerebral brain tumors as a method for evaluation of therapeutic drug combinations

Autor: W J, Bodell

Publikováno v: Anticancer research. 20(5A)

Rats with 9L or 9L-2 intracerebral brain tumors were treated with streptozotocin (STZ) and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) at various doses either as single agents or in combination. Treatment of rats bearing 9L or 9L-2 tumors with either

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1353acc061341d90001e30cdeb922590
https://pubmed.ncbi.nlm.nih.gov/11062728

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Production of 8-hydroxy-2'-deoxguanosine in DNA by microsomal activation of tamoxifen and 4-hydroxytamoxifen

Autor: Q, Ye, W J, Bodell

Publikováno v: Carcinogenesis. 17(8)

Using rat liver microsomal preparations, we have investigated the activation of the anti-estrogen compound tamoxifen (TAM) and its metabolite 4-hydroxytamoxifen (4-OH-TAM) to form 8-hydroxy-2'-deoxyguanosine (8-OH-dG) in DNA. When reduced nicotinamid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::637ec6c5a62ba936cfbca0a45c7e210c
https://pubmed.ncbi.nlm.nih.gov/8761436

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Detection of DNA adducts in the white blood cells of B6C3F1 mice treated with benzene

Autor: G, Lévay, D N, Pathak, W J, Bodell

Publikováno v: Carcinogenesis. 17(1)

We have employed the P1-enhanced 32P-postlabeling procedure to detect the formation DNA of adducts in the white blood cells (WBC) of B6C3F1 mice treated by i.p. injection with benzene. Treatment twice a day with 440 mg/kg benzene for 1-7 days resulte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f411dd564e64790cb941b3c37260b4b4
https://pubmed.ncbi.nlm.nih.gov/8565125

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Tamoxifen metabolic activation: comparison of DNA adducts formed by microsomal and chemical activation of tamoxifen and 4-hydroxytamoxifen with DNA adducts formed in vivo

Autor: B, Moorthy, P, Sriram, D N, Pathak, W J, Bodell, K, Randerath

Publikováno v: Cancer research. 56(1)

One of our laboratories recently showed by 32P-postlabeling that administration of tamoxifen to mice induces two groups of hepatic DNA adducts comprising two major spots, nos. 3 and 5, respectively. 4-Hydroxytamoxifen and alpha-hydroxytamoxifen appea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::98ed1adb446aa114a5e50e37be98465c
https://pubmed.ncbi.nlm.nih.gov/8548775

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Activation of the tamoxifen derivative metabolite E to form DNA adducts: comparison with the adducts formed by microsomal activation of tamoxifen

Autor: K, Pongracz, D N, Pathak, T, Nakamura, A L, Burlingame, W J, Bodell

Publikováno v: Cancer research. 55(14)

(Z)-1,2-Diphenyl-1-(4-hydroxyphenyl)but-1-ene (metabolite E) has been detected in the plasma of patients treated with tamoxifen. We therefore investigated whether the cis/trans isomers of metabolite E can be activated to form DNA adducts detected by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9630187bfae90c2946054c11e817f234
https://pubmed.ncbi.nlm.nih.gov/7606720

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The effects of incorporation of bromodeoxyuridine into mammalian DNA on the migration patterns of DNA fragments subjected to pulsed-field gel electrophoresis after X irradiation or cutting with a restriction enzyme

Autor: D L, Latz, M M, Trinh, L L, Thompson, K, Gardiner, Y, Zhu, W J, Bodell, W C, Dewey

Publikováno v: Radiation research. 138(1)

Incorporation of bromodeoxyuridine (BrdU) into DNA in both Chinese hamster ovary (CHO) cells and human melanoma (U1) cells reduced the rate of DNA migration in transverse alternating-field electrophoresis (TAFE) agarose gel optimized for separating m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::11f08502dd2357f9e65f849895d066b7
https://pubmed.ncbi.nlm.nih.gov/8146300

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Restriction endonuclease recognition and southern hybridization of bromodeoxyuridine-substituted genomic DNA

Autor: H. Hirai, A. Asai, T. Hoshino, W. J. Bodell

Publikováno v: Cell proliferation. 26(3)

Human glioma cell lines exposed to various concentrations of bromodeoxyuridine (BrdUrd) were studied to determine the effect of BrdUrd substitution on restriction endonuclease recognition and Southern hybridization of genomic DNA. BrdUrd substitution

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e46c50dd76cf3f31289fce4f1ec9398
https://pubmed.ncbi.nlm.nih.gov/8391858

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3-Methyladenine DNA glycosylase activity in a glial cell line sensitive to the haloethylnitrosoureas in comparison with a resistant cell line

Autor: Z, Matijasevic, W J, Bodell, D B, Ludlum

Publikováno v: Cancer research. 51(5)

Extracts of a glial cell line (SF-126) which is sensitive to the cytotoxic effect of the haloethylnitrosoureas and of a cell line (SF-188) which is resistant to these agents have been tested for their ability to release methylated bases from a DNA su

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd7473b398e11956a6b0259ab941c094
https://pubmed.ncbi.nlm.nih.gov/1997198

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