Zobrazeno 1 - 10
of 87
pro vyhledávání: '"W Ivan Morrison"'
Autor:
David Wragg, Elizabeth A J Cook, Perle Latré de Laté, Tatjana Sitt, Johanneke D Hemmink, Maurine C Chepkwony, Regina Njeru, E Jane Poole, Jessica Powell, Edith A Paxton, Rebecca Callaby, Andrea Talenti, Antoinette A Miyunga, Gideon Ndambuki, Stephen Mwaura, Harriet Auty, Oswald Matika, Musa Hassan, Karen Marshall, Timothy Connelley, Liam J Morrison, B Mark deC Bronsvoort, W Ivan Morrison, Philip G Toye, James G D Prendergast
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010099 (2022)
East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Bos
Externí odkaz:
https://doaj.org/article/b0a1ab77394044a9b14c19369b4212a7
Autor:
Nicholas C Palmateer, Kyle Tretina, Joshua Orvis, Olukemi O Ifeonu, Jonathan Crabtree, Elliott Drabék, Roger Pelle, Elias Awino, Hanzel T Gotia, James B Munro, Luke Tallon, W Ivan Morrison, Claudia A Daubenberger, Vish Nene, Donald P Knowles, Richard P Bishop, Joana C Silva
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008781 (2020)
Theileria parva is an economically important, intracellular, tick-transmitted parasite of cattle. A live vaccine against the parasite is effective against challenge from cattle-transmissible T. parva but not against genotypes originating from the Afr
Externí odkaz:
https://doaj.org/article/8f70a77d240e4115906cbd29836599c8
Autor:
Shan Goh, Daniel Ngugi, Regina Lizundia, Isabel Hostettler, Kerry Woods, Keith Ballingall, Niall D MacHugh, W Ivan Morrison, Willie Weir, Brian Shiels, Dirk Werling
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162571 (2016)
As part of an international effort to develop vaccines for Theileria lestoquardi, we undertook a limited screen to test T. lestoquardi orthologues of antigens recognised by CD8+ T lymphocyte responses against T. annulata and T. parva in cattle. Five
Externí odkaz:
https://doaj.org/article/9bdff7d4b71c40cfb57718abcffd4b3b
Autor:
Lindsay M Fry, David A Schneider, Charles W Frevert, Danielle D Nelson, W Ivan Morrison, Donald P Knowles
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0156004 (2016)
Respiratory failure and death in East Coast Fever (ECF), a clinical syndrome of African cattle caused by the apicomplexan parasite Theileria parva, has historically been attributed to pulmonary infiltration by infected lymphocytes. However, immunohis
Externí odkaz:
https://doaj.org/article/8df72094a1af49839e8c56d59c495742
Autor:
Gillian J Wilson, Keun Seok Seo, Robyn A Cartwright, Timothy Connelley, Olivia N Chuang-Smith, Joseph A Merriman, Caitriona M Guinane, Joo Youn Park, Gregory A Bohach, Patrick M Schlievert, W Ivan Morrison, J Ross Fitzgerald
Publikováno v:
PLoS Pathogens, Vol 7, Iss 10, p e1002271 (2011)
Bacterial superantigens (SAg) stimulate T-cell hyper-activation resulting in immune modulation and severe systemic illnesses such as Staphylococcus aureus toxic shock syndrome. However, all known S. aureus SAgs are encoded by mobile genetic elements
Externí odkaz:
https://doaj.org/article/bd56f7a9b7594e6393143c69934225eb
Autor:
Roger Pelle, Simon P Graham, Moses N Njahira, Julius Osaso, Rosemary M Saya, David O Odongo, Philip G Toye, Paul R Spooner, Anthony J Musoke, Duncan M Mwangi, Evans L N Taracha, W Ivan Morrison, William Weir, Joana C Silva, Richard P Bishop
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19015 (2011)
Theileria parva causes an acute fatal disease in cattle, but infections are asymptomatic in the African buffalo (Syncerus caffer). Cattle can be immunized against the parasite by infection and treatment, but immunity is partially strain specific. Ava
Externí odkaz:
https://doaj.org/article/3ce08aaecc574375b437ae2f7867f147
Autor:
Isabel K Macdonald, Maria Harkiolaki, Lawrence Hunt, Timothy Connelley, A Victoria Carroll, Niall D MacHugh, Simon P Graham, E Yvonne Jones, W Ivan Morrison, Darren R Flower, Shirley A Ellis
Publikováno v:
PLoS Pathogens, Vol 6, Iss 10, p e1001149 (2010)
T cell receptor (TCR) recognition of peptide-MHC class I (pMHC) complexes is a crucial event in the adaptive immune response to pathogens. Peptide epitopes often display a strong dominance hierarchy, resulting in focusing of the response on a limited
Externí odkaz:
https://doaj.org/article/dc0bc3cc205e45e6bb0790896cba9fc0
Autor:
K.R. Parsons, Olukemi O. Ifeonu, Emilio Fenoy, Kyle Tretina, Morten Nielsen, Timothy Connelley, Nicholas C. Palmateer, W. Ivan Morrison, Adriana Aguado, Tara A. Sheldrake, Joana C. Silva
Publikováno v:
Morrison, I, Aguado-Martinez, A, Sheldrake, T, Palmateer, N C, Ifeonu, O O, Tretina, K, Parsons, K, Fenoy, E, Connelley, T, Nielsen, M & Silva, J C 2021, ' CD4 T cell responses to Theileria parva in immune cattle recognise a diverse set of parasite antigens presented on the surface of infected lymphoblasts ', Journal of Immunology, vol. 207, no. 8, pp. 1965-1977 . https://doi.org/10.4049/jimmunol.2100331
Parasite-specific CD8 T cell responses play a key role in mediating immunity against Theileria parva in cattle (Bos taurus), and there is evidence that efficient induction of these responses requires CD4 T cell responses. However, information on the
Publikováno v:
Morrison, I, Sheldrake, T & Connelley, T 2022, ' Antibodies that react with bovine T lymphocytes expressing the T cell receptor β chain subgroup BV20 inhibit antigen recognition ', Veterinary Immunology and Immunopathology, vol. 246, 110392 . https://doi.org/10.1016/j.vetimm.2022.110392
In recent years, molecular studies have provided detailed information on the bovine T cell receptor (TCR) variable gene repertoire, both in resting T cells and during T cell responses. However, studies of the biological function of the receptor have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca9dedad524ecd6bec26b1b0aeb1ec2
https://www.pure.ed.ac.uk/ws/files/251498225/Morrison_et_al_bovine_TCR_revised_Jan_2022.pdf
https://www.pure.ed.ac.uk/ws/files/251498225/Morrison_et_al_bovine_TCR_revised_Jan_2022.pdf
Publikováno v:
International Journal for Parasitology
Morrison, I, Hemmink, J D & Toye, P G 2020, ' Theileria parva : a parasite of African buffalo, which has adapted to infect and undergo transmission in cattle ', International Journal For Parasitology . https://doi.org/10.1016/j.ijpara.2019.12.006
Morrison, I, Hemmink, J D & Toye, P G 2020, ' Theileria parva : a parasite of African buffalo, which has adapted to infect and undergo transmission in cattle ', International Journal For Parasitology . https://doi.org/10.1016/j.ijpara.2019.12.006
Graphical abstract
Highlights • Theileria parva parasites show extensive genotypic diversity and undergo frequent genetic recombination during tick transmission. • Theileria parva maintained in cattle is much less genotypically diverse than
Highlights • Theileria parva parasites show extensive genotypic diversity and undergo frequent genetic recombination during tick transmission. • Theileria parva maintained in cattle is much less genotypically diverse than