Zobrazeno 1 - 10
of 32
pro vyhledávání: '"W I P Mainwaring"'
Autor:
R. J. B. King, W. I. P. Mainwaring
Steroid–Cell Interactions describes the processes involved in the intracellular binding of steroids (and related compounds) in mammalian cells. Serum binding proteins and steroid-immunoglobulin interaction are also discussed, along with the relatio
Publikováno v:
Biochemical Journal. 160:43-48
Tissue wet weight, nucleic acid content and epithelial and stromal cell numbers were measured in the seminal vesicles of sexually mature male rats. After castration, tissue weight and RNA decreased rapidly and in aprallel to reach, after 14 days, val
Publikováno v:
British Journal of Cancer
The in vivo antiandrogenicity of Casodex has been confirmed and characterised. Androgen receptor (AR) binding assays of rat ventral prostate gland cytosols revealed a relative binding affinity (RBA) for the AR of 0.267 and a k1 of 1.25 x 10(-7) M for
Publikováno v:
Biochemical Journal. 170:115-121
The presence of three major proteins alpha, beta and gamma in rat ventral prostate was demonstrated by electrophoresis in polyacrylamide gels containing sodium dodecyl sulphate. Their regulation by androgens was studied by measuring the rates of synt
Publikováno v:
Biochemical Journal. 144:413-426
1. Aldolase was selected as a suitable marker for following the androgenic regulation of mRNA synthesis in the prostate gland. 2. Antibodies raised in rabbits against crystalline prostate aldolase were used to monitor the synthesis of this androgen-i
Autor:
W. I. P. Mainwaring
Publikováno v:
Biochemical Society Transactions. 7:556-559
Publikováno v:
Biochemical Journal. 158:271-282
1. Two basic proteins were purified from secretions of rat seminal vesicles by using Sephadex G-200 chromatography and polyacrylamide-gel electrophoresis under denaturing conditions. 2. It is not certain that these two proteins are distinct species a
Publikováno v:
Journal of Urology. 120:180-183
An in vitro test system suitable to assess the potency of putative antiandrogens has been developed, using the human benign prostatic tissue obtained at operation. The system circumvents some problems associated with using human tissue, such as the p
Publikováno v:
Endocrine Research Communications. 2:25-45
The physicochemical properties of the androgen-receptor complex in mouse kidney were determined. The sedimentation coefficient, 7.9S and Stokes radius of 82A, are compatible with an asymmetric protein [frictional ratio f/fo 1.98; axial ratio, assumin
Publikováno v:
Biochemical Journal. 125:285-295
1. A system has been developed for the specific transfer of [3H]dihydrotestosterone–receptor complexes into prostatic chromatin in vitro. 2. Under optimum conditions the overall transfer of [3H]dihydrotestosterone into purified chromatin in this re