Zobrazeno 1 - 10 of 279 pro vyhledávání: '"W I McDonald"'
1
HLA genetic determinants in familial MS
Autor: A. W. Downie, D. A. Francis, J. E. C. Hern, W. I. McDonald, S. N. Hing, I. A. Dodi, J. R. Batchelor
Publikováno v: Tissue Antigens. 29:7-12
Fourteen multiplex MS families, 9 single-case MS families and 11 normal families from the Grampian region of North-East Scotland were studied. The prevalence rate of MS for individuals in multiplex families was calculated at 809/100,000; 4.5 times th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9299a8ad00c1444c1cdfc3bc89e99138
https://doi.org/10.1111/j.1399-0039.1987.tb01542.x
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3
High field MRI correlates of myelin content and axonal density in multiple sclerosis
Autor: Gareth J. Barker, J. Newcombe, W. I. McDonald, M Clemence, Klaus Schmierer, Roger J. Ordidge, M. L. Cuzner, Ps Tofts, Francesco Scaravilli, J. P. Mottershead, John S. Thornton, DH Miller
Publikováno v: Journal of Neurology. 250:1293-1301
Different MRI techniques are used to investigate multiple sclerosis (MS) in vivo. The pathological specificity of these techniques is poorly understood, in particular their relationship to demyelination and axonal loss. The aim of this study was to e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e12ee0bd7d416ba6d87cb7533884c85
https://doi.org/10.1007/s00415-003-0192-3
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4
Diagnostic criteria for primary progressive multiple sclerosis: A position paper
Autor: Alan J. Thompson, David Miller, Massimo Filippi, Bruno Brochet, Xavier Montalban, Chris H. Polman, W. I. McDonald, Frederik Barkhof, Valerie L. Stevenson
Publikováno v: Annals of Neurology, 47, 831-835. John Wiley and Sons Inc.
Thompson, A J, Montalban, X, Barkhof, F, Brochet, B, Filippi, M, Miller, D H, Polman, C H, Stevenson, V L & McDonald, W I 2000, ' Diagnostic criteria for primary progressive mutiple sclerosis: a position paper. ', Annals of Neurology, vol. 47, pp. 831-835 . https://doi.org/10.1002/1531-8249(200006)47:6<831::AID-ANA21>3.0.CO;2-H
The unique clinical characteristics of primary progressive multiple sclerosis (PPMS) pose particular diagnostic difficulties, both in excluding other causes of progressive syndromes and in confirming the diagnosis of MS, which is not adequately addre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463053aef791fe0c3edaa4c6253768ac
https://doi.org/10.1002/1531-8249(200006)47:6<831::aid-ana21>3.0.co
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5
Recovery from optic neuritis is associated with a change in the distribution of cerebral response to visual stimulation: a functional magnetic resonance imaging study
Autor: David Miller, Adriana Brusa, Edward T. Bullmore, Michael Brammer, Gordon T. Plant, Alan J. Thompson, Ahmed T. Toosy, Vincent Giampietro, W. I. McDonald, P A Brex, Gareth J. Barker, D. G. MacManus, David J. Werring, I. F. Moseley
Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 68:441-449
Objectives—Recovery to normal or near normal visual acuity is usual after acute demyelinating optic neuritis, despite the frequent persistence of conduction abnormalities as evidenced by the visual evoked potential (VEP). This raises the possibilit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f890848e7215f3bd6b2dcb6a3afd85
https://doi.org/10.1136/jnnp.68.4.441
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6
Multiple sclerosis⋮ the disease and its manifestations
Autor: W. I. McDonald, M. A. Ron
Publikováno v: Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 354:1615-1622
Multiple sclerosis is an immune–mediated inflammatory demyelinating disease of the central nervous system clinically characterized by relapses and remissions of neurological disturbance. A typical relapse, exemplified by optic neuritis, increases i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae7920b5f3bc3472ecfb01d6b613869f
https://doi.org/10.1098/rstb.1999.0506
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7
The pathophysiology of multiple sclerosis⋮ the mechanisms underlying the production of symptoms and the natural history of the disease
Autor: Kenneth Smith, W. I. McDonald
Publikováno v: Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences. 354:1649-1673
The pathophysiology of multiple sclerosis is reviewed, with emphasis on the axonal conduction properties underlying the production of symptoms, and the course of the disease. The major cause of the negative symptoms during relapses (e.g. paralysis, b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29f3146991bf9c5c2abe68e7bcf92cf
https://doi.org/10.1098/rstb.1999.0510
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8
Physicians, subsequence and consequence
Autor: W. I. McDonald
Publikováno v: Journal of Neurology, Neurosurgery & Psychiatry. 67:282-289
Based on the 2nd Meadows Memorial Lecture, given at the Royal College of Physicians, London, on the occasion of the meeting of the European Neuro-ophthalmological Society, in May 1997 The title of my lecture derives from a statement by the great lexi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702c381926efd89011dafba2f680e475
https://doi.org/10.1136/jnnp.67.3.282
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9
Comparison of multiple sclerosis clinical subgroups using navigated spin echo diffusion-weighted imaging
Autor: W. I. McDonald, C A Clark, David J. Werring, Gareth J. Barker, A G Droogan, David Miller
Publikováno v: Magnetic Resonance Imaging. 17:653-661
The apparent diffusion coefficient (ADC) of tissue provides an indication of the size, shape, and orientation of the water spaces in tissue. Thus, pathologic differences between lesions in multiple sclerosis (MS) patients with different clinical cour
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b529d1ebd031ea5ce5e027036fb109f
https://doi.org/10.1016/s0730-725x(99)00011-9
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10
Central nervous system sarcoidosisdiagnosis and management
Autor: I. F. Moseley, D Mitchell, John Zajicek, O Foster, M Rovaris, J W Scadding, V. Chamoun, J Evanson, W. I. McDonald, David Miller, E J Thompson, N.J. Scolding
Publikováno v: QJM. 92:103-117
A series of 68 patients with neurosarcoidosis is reported, with particular emphasis on clinical aspects, diagnosis and treatment. A classification system based on clinical diagnostic probability is proposed, consisting of probable and definite diseas
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f31d61e7f0e6cb8e79f7daaa7ebf48
https://doi.org/10.1093/qjmed/92.2.103
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