Zobrazeno 1 - 10
of 242
pro vyhledávání: '"W Henry Boom"'
Autor:
Etthel M Windels, Eddie M Wampande, Moses L Joloba, W Henry Boom, Galo A Goig, Helen Cox, Jerry Hella, Sonia Borrell, Sebastien Gagneux, Daniela Brites, Tanja Stadler
Publikováno v:
PLoS Pathogens, Vol 20, Iss 5, p e1011675 (2024)
Persons living with HIV are known to be at increased risk of developing tuberculosis (TB) disease upon infection with Mycobacterium tuberculosis (Mtb). However, it has remained unclear how HIV co-infection affects subsequent Mtb transmission from the
Externí odkaz:
https://doaj.org/article/e1114ebdf0ff4fb09f88e313280d9faa
Autor:
Bonnie A Thiel, Kathleen C Lundberg, Daniela Schlatzer, Jessica Jarvela, Qing Li, Rachel Shaw, Scott M Reba, Shane Fletcher, Sara E Beckloff, Mark R Chance, W Henry Boom, Richard F Silver, Gurkan Bebek
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0295312 (2024)
Alveolar macrophages (AM) perform a primary defense mechanism in the lung through phagocytosis of inhaled particles and microorganisms. AM are known to be relatively immunosuppressive consistent with the aim to limit alveolar inflammation and maintai
Externí odkaz:
https://doaj.org/article/54105e345f794436b1daf7cc01852db1
Autor:
Michael L McHenry, Jason Simmons, Hyejeong Hong, LaShaunda L Malone, Harriet Mayanja-Kizza, William S Bush, W Henry Boom, Thomas R Hawn, Scott M Williams, Catherine M Stein
Publikováno v:
PLoS Genetics, Vol 19, Iss 3, p e1010387 (2023)
BackgroundTuberculosis (TB) remains a major public health problem globally, even compared to COVID-19. Genome-wide studies have failed to discover genes that explain a large proportion of genetic risk for adult pulmonary TB, and even fewer have exami
Externí odkaz:
https://doaj.org/article/2e0843db2b3d420391bf11e8daa773b9
Autor:
Jason D Simmons, R Max Segnitz, Kimberly A Dill-McFarland, Catherine M Stein, Glenna J Peterson, Harriet Mayanja-Kizza, W Henry Boom, Thomas R Hawn
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284498 (2023)
BackgroundA mechanistic understanding of uncommon immune outcomes such as resistance to infection has led to the development of novel therapies. Using gene level analytic methods, we previously found distinct monocyte transcriptional responses associ
Externí odkaz:
https://doaj.org/article/18e905409be14fb8b0a6884e0c8d5dbf
Autor:
Bonnie A Thiel, William Worodria, Sophie Nalukwago, Mary Nsereko, Ingvar Sanyu, Lalitha Rejani, Josephine Zawedde, David H Canaday, Catherine M Stein, Keith A Chervenak, LaShaunda L Malone, Ronald Kiyemba, Richard F Silver, John L Johnson, Harriet Mayanja-Kizza, W Henry Boom
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0249477 (2021)
BackgroundThe search for immune correlates of protection against Mycobacterium tuberculosis (MTB) infection in humans is limited by the focus on peripheral blood measures. Bronchoalveolar lavage (BAL) can safely be done and provides insight into cell
Externí odkaz:
https://doaj.org/article/1dc85d37d8f842fab88fbb40f511fb63
Autor:
Michael L McHenry, Jacquelaine Bartlett, Robert P Igo, Eddie M Wampande, Penelope Benchek, Harriet Mayanja-Kizza, Kyle Fluegge, Noemi B Hall, Sebastien Gagneux, Sarah A Tishkoff, Christian Wejse, Giorgio Sirugo, W Henry Boom, Moses Joloba, Scott M Williams, Catherine M Stein
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008728 (2020)
Genetic studies of both the human host and Mycobacterium tuberculosis (MTB) demonstrate independent association with tuberculosis (TB) risk. However, neither explains a large portion of disease risk or severity. Based on studies in other infectious d
Externí odkaz:
https://doaj.org/article/1f2b4f7ef2014e068b5e31f09d69b027
Autor:
Eddie M Wampande, Peter Naniima, Ezekiel Mupere, David P Kateete, LaShaunda L Malone, Catherine M Stein, Harriet Mayanja-Kizza, Sebastien Gagneux, W Henry Boom, Moses L Joloba
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221644 (2019)
BackgroundLimited data existed exclusively describing Mycobacterium tuberculosis lineage 3 (MTB-L3), sub-lineages, and clinical manifestations in Kampala, Uganda. This study sought to elucidate the circulating MTB-L3 sub-lineages and their correspond
Externí odkaz:
https://doaj.org/article/b63eec520c404996bfb2cd37bf48413d
Autor:
Thomas J Scriba, Adam Penn-Nicholson, Smitha Shankar, Tom Hraha, Ethan G Thompson, David Sterling, Elisa Nemes, Fatoumatta Darboe, Sara Suliman, Lynn M Amon, Hassan Mahomed, Mzwandile Erasmus, Wendy Whatney, John L Johnson, W Henry Boom, Mark Hatherill, Joe Valvo, Mary Ann De Groote, Urs A Ochsner, Alan Aderem, Willem A Hanekom, Daniel E Zak, other members of the ACS cohort study team
Publikováno v:
PLoS Pathogens, Vol 13, Iss 11, p e1006687 (2017)
Our understanding of mechanisms underlying progression from Mycobacterium tuberculosis infection to pulmonary tuberculosis disease in humans remains limited. To define such mechanisms, we followed M. tuberculosis-infected adolescents longitudinally.
Externí odkaz:
https://doaj.org/article/1123ad39de7647288ab1f6500ddd06d0
Autor:
Rafal S Sobota, Catherine M Stein, Nuri Kodaman, Isaac Maro, Wendy Wieland-Alter, Robert P Igo, Albert Magohe, LaShaunda L Malone, Keith Chervenak, Noemi B Hall, Mecky Matee, Harriet Mayanja-Kizza, Moses Joloba, Jason H Moore, William K Scott, Timothy Lahey, W Henry Boom, C Fordham von Reyn, Scott M Williams, Giorgio Sirugo
Publikováno v:
PLoS Genetics, Vol 13, Iss 6, p e1006710 (2017)
One in three people has been infected with Mycobacterium tuberculosis (MTB), and the risk for MTB infection in HIV-infected individuals is even higher. We hypothesized that HIV-positive individuals living in tuberculosis-endemic regions who do not ge
Externí odkaz:
https://doaj.org/article/39b8f996319a481d8ac25d7c8934bd1c
Autor:
Chetan Seshadri, Nafiseh Sedaghat, Monica Campo, Glenna Peterson, Richard D Wells, Gregory S Olson, David R Sherman, Catherine M Stein, Harriet Mayanja-Kizza, Ali Shojaie, W Henry Boom, Thomas R Hawn, Tuberculosis Research Unit (TBRU)
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175844 (2017)
RationaleUnderstanding mechanisms of resistance to M. tuberculosis (M.tb) infection in humans could identify novel therapeutic strategies as it has for other infectious diseases, such as HIV.ObjectivesTo compare the early transcriptional response of
Externí odkaz:
https://doaj.org/article/be1f5fc0e02c4c509ccb60eacd7db1ef