Zobrazeno 1 - 10 of 30 pro vyhledávání: '"W H, TSIEN"'
1
Humanized Mik beta 1, a humanized antibody to the IL-2 receptor beta-chain that acts synergistically with humanized anti-TAC
Autor: J Hakimi, V C Ha, P Lin, E Campbell, M K Gately, M Tsudo, P W Payne, T A Waldmann, A J Grant, W H Tsien
Publikováno v: The Journal of Immunology. 151:1075-1085
Mik beta 1 is a mouse mAb directed at the beta-subunit of the human IL-2R (Tac) that inhibits IL-2 binding and inhibits IL-2 induction of large granular lymphocytes (LGL). Mik beta 1 alone does not inhibit IL-2-induced T-cell proliferation, but acts
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85e4cc717588c7324b2591b92702ec69
https://doi.org/10.4049/jimmunol.151.2.1075
Zobrazit plný text záznamu
2
Identification of sites on the human Fc epsilon RI alpha subunit which are involved in binding human and rat IgE
Autor: M A, Mallamaci, R, Chizzonite, M, Griffin, M, Nettleton, J, Hakimi, W H, Tsien, J P, Kochan
Publikováno v: The Journal of biological chemistry. 268(29)
The high affinity IgE Fc receptor (Fc epsilon RI), found on mast cells and basophils, is a tetrameric receptor complex. The extracellular portion of the Fc epsilon RI alpha subunit consists of two immunoglobulin-like domains and binds IgE in the abse
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c2ccd0f1d55fd8db3febf35bf43b6caf
https://pubmed.ncbi.nlm.nih.gov/8408065
Zobrazit plný text záznamu
3
Purification and characterization of human recombinant IgE-Fc fragments that bind to the human high affinity IgE receptor
Autor: M, Basu, J, Hakimi, E, Dharm, J A, Kondas, W H, Tsien, R S, Pilson, P, Lin, A, Gilfillan, P, Haring, E H, Braswell
Publikováno v: The Journal of biological chemistry. 268(18)
The Fc-region of immunoglobulin E (IgE) comprising C epsilon 2, C epsilon 3, and C epsilon 4 domains is sufficient for binding to the alpha chain of the high affinity IgE-Fc receptor (Fc epsilon RI alpha). In order to identify the smallest Fc fragmen
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::008fe5027c01f00d6683a5c9a1447e4b
https://pubmed.ncbi.nlm.nih.gov/7685756
Zobrazit plný text záznamu
4
Localization in human interleukin 2 of the binding site to the alpha chain (p55) of the interleukin 2 receptor
Autor: J A Kondas, C Spence, M Nachman, P Bailon, K Sauvé, W H Tsien, Grace Ju, E Campbell, John Hakimi
Human interleukin 2 (IL-2) analogs with defined amino acid substitutions were used to identify specific residues that interact with the 55-kDa subunit (p55) or alpha chain of the human IL-2 receptor. Analog proteins containing specific substitutions
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c4c389634ac790f6208c91abcd215c6
https://europepmc.org/articles/PMC51720/
Zobrazit plný text záznamu
5
Structure-function analysis of human interleukin-2. Identification of amino acid residues required for biological activity
Autor: Robert M. Crowl, R Bhatt, P L Kilian, K L Kaffka, L Collins, W H Tsien, Richard Anthony Chizzonite, Grace Ju
Publikováno v: Journal of Biological Chemistry. 262:5723-5731
To locate functional domains of the interleukin-2 (IL-2) protein, a cDNA clone encoding biologically active human IL-2 was mutagenized using synthetic oligonucleotides to incorporate defined amino acid substitutions and deletions in the mature protei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::34c3ba0770f7c701f9f79be7f7f5490a
https://doi.org/10.1016/s0021-9258(18)45635-9
Zobrazit plný text záznamu
6
Identification of specific residues of human interleukin 2 that affect binding to the 70-kDa subunit (p70) of the interleukin 2 receptor
Autor: L Collins, G Ju, D V Weber, C Seals, W H Tsien, V Toome, John Hakimi, P Bailon, Warner C. Greene, J Hoskings
Publikováno v: Proceedings of the National Academy of Sciences. 85:7709-7713
Analogs of interleukin 2 containing defined amino acid substitutions and deletions were assayed for bioactivity and for competitive binding to the high-affinity human interleukin 2 receptor complex and its two component subunits, a 55-kDa subunit (p5
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd089bc467621c7f7f9478fa9fbd91d
https://doi.org/10.1073/pnas.85.20.7709
Zobrazit plný text záznamu
7
Structure-function analysis of human interleukin-2. Identification of amino acid residues required for biological activity
Autor: G, Ju, L, Collins, K L, Kaffka, W H, Tsien, R, Chizzonite, R, Crowl, R, Bhatt, P L, Kilian
Publikováno v: The Journal of biological chemistry. 262(12)
To locate functional domains of the interleukin-2 (IL-2) protein, a cDNA clone encoding biologically active human IL-2 was mutagenized using synthetic oligonucleotides to incorporate defined amino acid substitutions and deletions in the mature protei
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50f0b61bde8c51dc3091f1ad988efdf0
https://pubmed.ncbi.nlm.nih.gov/3106342
Zobrazit plný text záznamu
10
Alterations in the hydrolytic activity, inhibitor sensitivity and molecular size of the rat erythrocyte cyclic AMP phosphodiesterase by calcium and hypertonic sodium chloride
Autor: H, Sheppard, W H, Tsien
Publikováno v: Journal of cyclic nucleotide research. 1(4)
Hypertonic NaCl irreversibly reduced the sensitivity of the rat erythrocyte cyclic AMP phosphodiesterase to inhibition by Ro 20-1724 but not by papavarine. This effect could be prevented by 1 mM EDTA and mimicked by by CaCl2. The reduction in inhibit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6fe5ec91182c37c0eb4eecf86e0d97ee
https://pubmed.ncbi.nlm.nih.gov/177464
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje