Zobrazeno 1 - 10 of 61 pro vyhledávání: '"W H, Okamura"'
1
Characterization of a Novel Analogue of 1α,25(OH)2-Vitamin D3 with Two Side Chains: Interaction with Its Nuclear Receptor and Cellular Actions
Autor: H. P. Koeffler, Anthony W. Norman, Manchand Ps, Sara Peleg, J. E. Bishop, Takeuchi Ja, Uskokovic Mr, W. H. Okamura, Hisatake Ji
Publikováno v: Journal of Medicinal Chemistry. 43:2719-2730
The hormone 1alpha,25(OH)(2)-vitamin D(3) (125D) binds to its nuclear receptor (VDR) to stimulate gene transcription activity. Inversion of configuration at C-20 of the side chain to generate 20-epi-1alpha,25(OH)(2)D(3) (20E-125D) increases transcrip
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9131444b16e49c345d757755680c91af
https://doi.org/10.1021/jm0000160
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5
Different shapes of the steroid hormone 1alpha,25(OH)(2)-vitamin D(3) act as agonists for two different receptors in the vitamin D endocrine system to mediate genomic and rapid responses
Autor: A W, Norman, H L, Henry, J E, Bishop, X D, Song, C, Bula, W H, Okamura
Publikováno v: Steroids. 66(3-5)
Vitamin D(3) produces biologic responses as a consequence of its metabolism into 1alpha,25(OH)(2)-vitamin D(3) [1alpha,25(OH)(2)D(3)] and 24R,25(OH)(2)-vitamin D(3). The metabolic production of these two seco steroids and their generation of the plet
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::52675cec833149192a3a051dc21f3b12
https://pubmed.ncbi.nlm.nih.gov/11179722
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6
Three-dimensional model of the ligand binding domain of the nuclear receptor for 1alpha,25-dihydroxy-vitamin D(3)
Autor: A W, Norman, D, Adams, E D, Collins, W H, Okamura, R J, Fletterick
Publikováno v: Journal of cellular biochemistry. 74(3)
A three-dimensional model for residues 142-427 of the ligand binding domain (LBD) of the human nuclear receptor for 1alpha, 25-dihydroxy-vitamin D(3) [VDR] has been generated based on the X-ray crystallographic atomic coordinates of the LBD of the ra
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0b48462dd8aca053ceaab1ba307b3681
https://pubmed.ncbi.nlm.nih.gov/10412035
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7
1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxyvitamin D3, is a potent suppressor of parathyroid hormone secretion
Autor: A J, Brown, C, Ritter, E, Slatopolsky, K R, Muralidharan, W H, Okamura, G S, Reddy
Publikováno v: Journal of cellular biochemistry. 73(1)
1Alpha,25(OH)2D3 is an important negative regulator of parathyroid hormone (PTH) gene transcription. In parathyroid cells, as in other target tissues, 1alpha,25(OH)2D3 is degraded by side chain oxidation by the inducible 24-hydroxylase. We have previ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::130a594d3198d65bd7ad2abdbe72f8de
https://pubmed.ncbi.nlm.nih.gov/10088729
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