Zobrazeno 1 - 9
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pro vyhledávání: '"W H, Gmeiner"'
Autor:
W. H. Gmeiner
Publikováno v:
Current Medicinal Chemistry. 5:115-135
NMR spectroscopy has been shown to be useful in determining the structures of nucleic acid fragments in solution. Over the last several years NMR spectroscopy, in conjunction with restrained molecular dynamics, has been employed to understand the 3D
Publikováno v:
Cell biochemistry and biophysics. 35(2)
SH3 domains are a conserved feature of many nonreceptor protein tyrosine kinases, such as Hck, and often function in substrate recruitment and regulation of kinase activity. SH3 domains modulate kinase activity by binding to polyproline helices (PPII
Autor:
R, Kotchetkov, B, Gröschel, W H, Gmeiner, A A, Krivtchik, E, Trump, M, Bitoova, J, Cinatl, B, Kornhuber
Publikováno v:
Anticancer research. 20(5A)
Gemcitabine (Gem) is a deoxycytidine analog that is effective against pancreatic cancer and other malignancies following conversion to the 5'-O-mono-, di- and tri-phosphate forms. We evaluated the cytotoxicity of GemMP[10], a novel multimeric form of
Autor:
W H, Gmeiner
Publikováno v:
Current medicinal chemistry. 5(2)
NMR spectroscopy has been shown to be useful in determining the structures of nucleic acid fragments in solution. Over the last several years NMR spectroscopy, in conjunction with restrained molecular dynamics, has been employed to understand the 3D
Publikováno v:
Journal of biomolecular NMR. 10(3)
The hematopoietic cellular kinase (Hck) is a member of the Src family of non-receptor protein-tyrosine kinases that is expressed predominantly in granulocytes, monocytes and macrophages. Recent observations suggest that Hck may be activated in HIV-in
Autor:
W H, Gmeiner, J C, Facelli
Publikováno v:
Biopolymers. 38(5)
Nuclear magnetic resonance spectroscopists are increasingly utilizing chemical shifts to characterize the secondary structure of proteins. The present study addresses the effects that the positively charged amino group at the N-terminus of a peptide
Publikováno v:
Biochemistry. 29(45)
The novel hybrid duplex alpha-5'-d[TACACA]-3'.beta-5'-r[AUGUGU]-3' was analyzed extensively by 1D and 2D NMR methods. Two forms of the duplex exist in about an 80:20 ratio. Analysis of the exchangeable imino protons of the major component revealed th
Publikováno v:
Journal of Clinical Oncology. 24:20014-20014
20014 Background: Changes in gene expression that occur during cellular transformation and establishment of metastases provide valuable information that may help determine prognosis and direct treatment. We have obtained gene expression profiles from
Autor:
W. H. Gmeiner, C. D. Poulter
Publikováno v:
ChemInform. 20