Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome

Autor: Fergal J. Duffy, January Weiner, Scott Hansen, David L. Tabb, Sara Suliman, Ethan Thompson, Jeroen Maertzdorf, Smitha Shankar, Gerard Tromp, Shreemanta Parida, Drew Dover, Michael K. Axthelm, Jayne S. Sutherland, Hazel M. Dockrell, Tom H. M. Ottenhoff, Thomas J. Scriba, Louis J. Picker, Gerhard Walzl, Stefan H. E. Kaufmann, Daniel E. Zak, The GC6-74 Consortium, S. H. E. Kaufmann, S. K. Parida, R. Golinski, J. Maertzdorf, J. Weiner, M. Jacobson, G. McEwen, G. Walzl, G. F. Black, G. van der Spuy, K. Stanley, M. Kriel, N. Du Plessis, N. Nene, A. G. Loxton, N. N. Chegou, S. Suliman, T. Scriba, M. Fisher, H. Mahomed, J. Hughes, K. Downing, A. Penn-Nicholson, H. Mulenga, B. Abel, M. Bowmaker, B. Kagina, W. Kwong, C. W. Hanekom, T. H. M. Ottenhoff, M. R. Klein, M. C. Haks, K. L. Franken, A. Geluk, K. E. van Meijgaarden, S. A. Joosten, D. van Baarle, F. Miedema, W. H. Boom, B. Thiel, J. Sadoff, D. Sizemore, S. Ramachandran, L. Barker, M. Brennan, F. Weichold, S. Muller, L. Geiter, G. Schoolnik, G. Dolganov, T. Van, H. Mayanja-Kizza, M. Joloba, S. Zalwango, M. Nsereko, B. Okwera, H. Kisingo, H. M. Dockrell, S. Smith, P. Gorak-Stolinska, Y.-G. Hur, M. Lalor, J.-S. Lee, A. C. Crampin, N. French, B. Ngwira, A. B. Smith, K. Watkins, L. Ambrose, F. Simukonda, H. Mvula, F. Chilongo, J. Saul, K. Branson, D. Kassa, A. Abebe, T. Mesele, B. Tegbaru, R. Howe, A. Mihret, A. Aseffa, Y. Bekele, R. Iwnetu, M. Tafesse, L. Yamuah, M. Ota, J. Sutherland, P. Hill, R. Adegbola, T. Corrah, M. Antonio, T. Togun, I. Adetifa, S. Donkor, P. Andersen, I. Rosenkrands, M. Doherty, K. Weldingh

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

There remains a pressing need for biomarkers that can predict who will progress to active tuberculosis (TB) after exposure to Mycobacterium tuberculosis (MTB) bacterium. By analyzing cohorts of household contacts of TB index cases (HHCs) and a string

Externí odkaz: https://doaj.org/article/1eba36dc045c44aa95b786e37918a63e

Selective HDAC3 Inhibitor Restricts Mycobacterial Growth and Modulates Macrophage Immune Responses

Autor: M. Campo-Patino, W. H. Boom, Catherine M. Stein, Glenna J. Peterson, S. Heater, T R Hawn, Jason D. Simmons, Harriet Mayanja-Kizza

Publikováno v: C27. TB TREATMENT.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d52c693cd82106f0db02212034657d3
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a4425

Polymorphisms in TICAM2 and IL1B are associated with TB

Autor: Keith A. Chervenak, L Tao, Robert P. Igo, Moses Joloba, Audrey H. Schnell, Brenda Okware, LaShaunda L. Malone, Noemi B. Hall, Harriet Mayanja-Kizza, Catherine M. Stein, T R Hawn, Barbara Truitt, Mary Nsereko, Christina Lancioni, W. H. Boom

Publikováno v: Genes and immunity

Background Human genetic susceptibility for tuberculosis (TB) has been demonstrated by several studies, but few have examined multiple innate and adaptive immunity genes comprehensively, age-specific effects, and/or resistance to Mycobacterium tuberc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce15b95abfdc4a3a71fad22d1a1fee1
http://europepmc.org/articles/PMC4352113

A Randomized Trial of Punctuated Antiretroviral Therapy in Ugandan HIV-Seropositive Adults With Pulmonary Tuberculosis and CD4+ T-Cell Counts of ≥350 cells/μL

Autor: P. Mugyenyi, Christopher C. Whalen, Harriet Mayanja-Kizza, Diane V. Havlir, Royce Lin, W. H. Boom, Edwin D. Charlebois, Ezekiel Mupere, M. W. Nanteza, Roy D. Mugerwa, Padmini Srikantiah

Publikováno v: The Journal of Infectious Diseases. 204:884-892

(See the editorial commentary by Von Reyn, on pages 817–9.) The epidemics of tuberculosis and human immunodeficiency virus type 1 (HIV) infection converged with the greatest intensity in sub-Saharan Africa. Both the incidence and the prevalence of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7d6e3bbadf1d0b274ceef21250ea33e1
https://doi.org/10.1093/infdis/jir503

Engineering Versatile Bacteria‐Derived Outer Membrane Vesicles: An Adaptable Platform for Advancing Cancer Immunotherapy.

Autor: Luo, Ziheng^1,2 (AUTHOR), Cheng, Xiang^1,2 (AUTHOR), Feng, Bin^1,2 (AUTHOR), Fan, Duoyang^1,2 (AUTHOR), Liu, Xiaohui^1,2 (AUTHOR), Xie, Ruyan^1,2 (AUTHOR), Luo, Ting^1,2 (AUTHOR), Wegner, Seraphine V.³ (AUTHOR), Ma, Dayou² (AUTHOR), Chen, Fei^1,2 (AUTHOR) fechen@csu.edu.cn, Zeng, Wenbin^1,2 (AUTHOR) wbzeng@csu.edu.cn

Publikováno v: Advanced Science. 9/4/2024, Vol. 11 Issue 33, p1-30. 30p.