Zobrazeno 1 - 10
of 30
pro vyhledávání: '"W H, Betts"'
Autor:
W. H. Betts, A. Slavotinek, Ian J. Forbes, S. H. Millard, Peter D. Zalewski, O. Kapaniris, A. D. Ward, Stephen F. Lincoln, I. B. Mahadevan
Publikováno v:
Journal of Histochemistry & Cytochemistry. 42:877-884
We used an intracellular zinc-specific fluorophore, Zinquin, in conjunction with fluorescence video image analysis, to reveal labile zinc in pancreatic islet cells, which concentrate this metal for use in synthesis, storage, and secretion of insulin.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c657c0e951e2d241825b16136179aa7
https://doi.org/10.1177/42.7.8014471
https://doi.org/10.1177/42.7.8014471
Publikováno v:
Biochemical Journal. 296:403-408
Zinquin [(2-methyl-8-p-toluenesulphonamido-6-quinolyloxy)-acetic acid], a membrane-permeant fluorophore specific for Zn(II), was used with spectrofluorimetry and video image analysis to reveal and quantify labile intracellular Zn. Zinquin labelled hu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0deca69cf58c4dd7037b9722a1c49afa
https://doi.org/10.1042/bj2960403
https://doi.org/10.1042/bj2960403
Autor:
W H Betts, Nicolette Kalafatis, J Broadbent, Theodore A. Macrides, David R. Haynes, Michael W. Whitehouse
Publikováno v:
Inflammopharmacology. 5(3)
A lipid-rich extract, preparared by supercritical fluid extraction of fresh stabilized mussel powder (Lyprinol), showed significant anti-inflammatory (AI) activity given therapeutically and prophylactically po to Wistar and Dark Agouti rats developin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac50178cb1d076da80aa2ec6ad4e1eba
https://pubmed.ncbi.nlm.nih.gov/17638133
https://pubmed.ncbi.nlm.nih.gov/17638133
Autor:
Stephen F. Lincoln, A. D. Ward, W. H. Betts, R. Borlinghaus, R. F. Seamark, Ian J. Forbes, Peter D. Zalewski
Publikováno v:
Chemistrybiology. 1(3)
Background : The transition metal Zn(II) is thought to regulate cell and tissue growth by enhancing mitosis (cell proliferation) and suppressing the counterbalancing process of apoptosis (gene-directed cell death). To investigate the role of Zn(II) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1528c548c843ab218685be72b464dbda
https://pubmed.ncbi.nlm.nih.gov/9383385
https://pubmed.ncbi.nlm.nih.gov/9383385
Publikováno v:
Immunology. 78(4)
This study examines the contribution of tachykinins to the processes of inflammation. Neurokinin A (NKA), neurokinin B (NKB) and eledoisin (E) but not kassinin (K) have similar effects to substance P (SP) in priming neutrophils for increased superoxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e03bcdf54af49ad38ac29ceb26d3fb3f
https://pubmed.ncbi.nlm.nih.gov/7684358
https://pubmed.ncbi.nlm.nih.gov/7684358
Publikováno v:
Biochemistry international. 24(6)
Zn2+ influences diverse cellular processes by poorly understood mechanisms. Some of these effects may be mediated by the protein kinase C (PKC) family of enzymes, since an influx of Zn2+ greatly increases their binding of regulatory ligand phorbol es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc48a5f2a7c2ce959907ad8991a93902
https://pubmed.ncbi.nlm.nih.gov/1781789
https://pubmed.ncbi.nlm.nih.gov/1781789
Publikováno v:
Biochemistry international. 22(4)
Putative binding sites for zinc are present in the regulatory domain of protein kinase C but a distinct role for zinc has not yet been proposed. Here we show that micromolar concentrations of zinc chloride cause pure rat brain protein kinase C to loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4f37bfddbae8e3534c2d8fc784cc04ca
https://pubmed.ncbi.nlm.nih.gov/2078198
https://pubmed.ncbi.nlm.nih.gov/2078198
Publikováno v:
FEBS letters. 273(1-2)
Protein kinase C was measured in the cytoskeletal fraction of lymphocytes, platelets and HL60 cells, by specific binding of [3H]phorbol dibutyrate and by immunoblotting with antibody to a consensus sequence in the regulatory domain of alpha-, beta- a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd505da1b77c894473900ad6fd65aca3
https://pubmed.ncbi.nlm.nih.gov/2226843
https://pubmed.ncbi.nlm.nih.gov/2226843
Publikováno v:
Biochimica et biophysica acta. 1043(3)
We examined the influence of various dietary oils, including linseed and fish oil on the relative rates of leukotriene B4 (LTB4) and LTB5 production by rat peritoneal exudate cells in five rat strains. While there was an association between the membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325927afecde27742b7fd954b9727ffc
https://pubmed.ncbi.nlm.nih.gov/2157490
https://pubmed.ncbi.nlm.nih.gov/2157490
Publikováno v:
Free radical biologymedicine. 9(4)
The Ca++ ionophore A23187 and phorbol 12-myristate 13-acetate (PMA) caused dose-dependent inhibition of phospholipid (PL) methylation in unfractionated mononuclear cells (MNC), monocytes, and lymphocytes as measured by incorporation of 3H-methyl-grou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d60afc2a259d8515fc66e60542d6a0f
https://pubmed.ncbi.nlm.nih.gov/2178146
https://pubmed.ncbi.nlm.nih.gov/2178146