Evaluation of single-strain Prevotella histicola on KLH-driven immune responses in healthy volunteers: A randomized controlled trial with EDP1815

Autor: Mahdi Saghari, Pim Gal, Hendrika W. Grievink, Erica S. Klaassen, Ahnjili Zhuparris, Andrea Itano, Mark Bodmer, Duncan McHale, Matthijs Moerland

Publikováno v: Medicine in Microecology, Vol 19, Iss , Pp 100088- (2024)

Introduction: EDP1815 is a single-strain of Prevotella histicola with preclinical immunomodulatory properties. The aim of this study was to evaluate pharmacodynamic effects of EDP1815 on the immune response following immunization with keyhole limpet

Externí odkaz: https://doaj.org/article/7384d8fe451f4d93a0aae74c68fc89e7

Cardiovascular risk factors: The effects of ageing and smoking on the immune system, an observational clinical study

Autor: H. W. Grievink, V. Smit, B. W. Huisman, P. Gal, Y. Yavuz, C. Klerks, C. J. Binder, I. Bot, J. Kuiper, A. C. Foks, M. Moerland

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Currently immunomodulatory compounds are under investigation for use in patients with cardiovascular disease, caused by atherosclerosis. These trials, using recurrent cardiovascular events as endpoint, require enrollment of large patient groups. We i

Externí odkaz: https://doaj.org/article/8fbe7440ded1492a8997a83cbb144e1a

Stimulation of the PD-1 Pathway Decreases Atherosclerotic Lesion Development in Ldlr Deficient Mice

Autor: Hendrika W. Grievink, Virginia Smit, Robin A. F. Verwilligen, Mireia N. A. Bernabé Kleijn, Diede Smeets, Christoph J. Binder, Hideo Yagita, Matthijs Moerland, Johan Kuiper, Ilze Bot, Amanda C. Foks

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

Aim: Signaling through the coinhibitory programmed death (PD)-1/PD-L1 pathway regulates T cell responses and can inhibit ongoing immune responses. Inflammation is a key process in the development of atherosclerosis, the underlying cause for the major

Externí odkaz: https://doaj.org/article/8a68e6a63e3b4c6fa29e0e4dced398a7

Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers

Autor: Wouter ten Voorde, Robert Rissmann, Michelle Osse, Manon A. A. Jansen, G. Feiss, Edwin Florencia, Mascha Schoonakker, Floris C. van Hindevoort, Matthijs Moerland, Erik Lubberts, Pieter W Hameeteman, Thomas P. Buters, Jeffrey Damman, Amit Patel, Iris M. E. Jansen, Marieke L. de Kam, Jacobus Burggraaf, Simon Yona, Derek W. Gilroy, Hendrika W. Grievink

Publikováno v: British Journal of Clinical Pharmacology, 88(2), 680-690. Wiley-Blackwell Publishing Ltd
British Journal of Clinical Pharmacology, 88(2), 680-690. WILEY

Aims: Whereas intravenous administration of Toll-like receptor 4 ligand lipopolysaccharide (LPS) to human volunteers is frequently used in clinical pharmacology studies, systemic use of LPS has practical limitations. We aimed to characterize the intr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb4f5bb07a1c0316ac2a4f7f02dc25a
http://www.scopus.com/inward/record.url?scp=85113808796&partnerID=8YFLogxK

Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study

Autor: Aliede E. in ‘t Veld, Hendrika W. Grievink, Johan L. van der Plas, Boukje C. Eveleens Maarse, Sebastiaan J. W. van Kraaij, Tess D. Woutman, Mascha Schoonakker, Naomi B. Klarenbeek, Marieke L. de Kam, Ingrid M. C. Kamerling, Manon A. A. Jansen, Matthijs Moerland

Publikováno v: Immunologic Research.

Based on its wide range of immunosuppressive properties, hydroxychloroquine (HCQ) is used for the treatment of several autoimmune diseases. Limited literature is available on the relationship between HCQ concentration and its immunosuppressive effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9df3cefc31d7bf3a9cb93f298e34ca68
https://doi.org/10.1007/s12026-023-09367-3