Zobrazeno 1 - 10
of 29
pro vyhledávání: '"W Gregory Somers"'
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009834 (2021)
Stem cells have the potential to maintain undifferentiated state and differentiate into specialized cell types. Despite numerous progress has been achieved in understanding stem cell self-renewal and differentiation, many fundamental questions remain
Externí odkaz:
https://doaj.org/article/5b81154239cb44039f705354796331a1
Autor:
Fengwei Yu, Nicole A Siddall, Mai Tran, Yu Cai, Hongyan Wang, Leonie M. Quinn, Nicole Dominado, John E. La Marca, W. Gregory Somers, James Heaney, Gary R. Hime
Publikováno v:
Stem Cell Reports
Summary The Drosophila testis has been fundamental to understanding how stem cells interact with their endogenous microenvironment, or niche, to control organ growth in vivo. Here, we report the identification of two independent alleles for the highl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28a2cd08b982b28762a42fcb31640fa1
Autor:
Amanda L. Richdale, Adrian M. Russo, Cheryl Dissanayake, Luke Isbel, John A. Lesku, W. Gregory Somers, Christopher A. Lowry, Matthew W. Hale, Adam J. Lawther, Stephen Kent, Benjamin M. Prior
Publikováno v:
Behavioural Brain Research. 359:918-926
Autism spectrum disorder (ASD) is a heterogeneous and highly heritable condition with multiple aetiologies. Although the biological mechanisms underlying ASD are not fully understood, evidence suggests that dysregulation of serotonergic systems play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d5586267bdebb27867ee72cd728165
https://doi.org/10.1016/j.bbr.2018.06.019
https://doi.org/10.1016/j.bbr.2018.06.019
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 17, Iss 10, p e1009834 (2021)
PLoS Genetics, Vol 17, Iss 10, p e1009834 (2021)
Stem cells have the potential to maintain undifferentiated state and differentiate into specialized cell types. Despite numerous progress has been achieved in understanding stem cell self-renewal and differentiation, many fundamental questions remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c604b98c27e2df935d3277f02e280b2f
https://doi.org/10.1371/journal.pgen.1009834
https://doi.org/10.1371/journal.pgen.1009834
Publikováno v:
SSRN Electronic Journal.
Stem cells have the potential to maintain the undifferentiated state and differentiate into specialized cell types. Despite numerous progresses have been achieved in understanding stem cell self-renewal and differentiation, many fundamental questions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f41a78978915dfceb615b140764bc0b5
https://doi.org/10.2139/ssrn.3616373
https://doi.org/10.2139/ssrn.3616373
Autor:
John E. La Marca, Helena E. Richardson, Adam H. Hart, W. Gregory Somers, Sarah T. Diepstraten, Amy L. Hodge, Hongyan Wang
Publikováno v:
Development.
One fundamental property of a stem cell niche is the exchange of molecular signals between its component cells. Niche models, such as the Drosophila melanogaster testis, have been instrumental in identifying and studying the conserved genetic factors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::793b7b3cff945aee5e8cea58f17db3e3
https://doi.org/10.1242/dev.174292
https://doi.org/10.1242/dev.174292
Autor:
W. Gregory Somers, Gary R. Hime
Publikováno v:
Cell Adhesion & Migration. 3:425-432
Metazoan growth and development is maintained by populations of undifferentiated cells, commonly known as stem cells. Stem cells possess several characteristic properties, including dividing through self-renewing divisions and generating progeny that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1451667883e8ba7e535f8383c929b02
https://doi.org/10.4161/cam.3.4.9913
https://doi.org/10.4161/cam.3.4.9913
Publikováno v:
The Journal of Cell Biology
Over the past decade, many of the key components of the genetic machinery that regulate the asymmetric division of Drosophila melanogaster neural progenitors, neuroblasts, have been identified and their functions elucidated. Studies over the past two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4a6dad1d4658e00d98faf150558e114
http://europepmc.org/articles/PMC2213578
http://europepmc.org/articles/PMC2213578
Publikováno v:
Nature. 449:96-100
A balance between self-renewal and differentiation is fundamental to stem cell and cancer biology. Drosophila neural stem cells achieve this through asymmetric cell division, during which factors influencing self-renewal and differentiation are unequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f323ceb276a6fed9e328c5d1f47f397
https://doi.org/10.1038/nature06056
https://doi.org/10.1038/nature06056
Autor:
Fan, Zhang, Zhen-Xing, Huang, Hongcun, Bao, Fei, Cong, Huashan, Wang, Phing Chian, Chai, Yongmei, Xi, Wanzhong, Ge, W Gregory, Somers, Ying, Yang, Yu, Cai, Xiaohang, Yang
Publikováno v:
Development (Cambridge, England). 143(1)
The mechanism for the basal targeting of the Miranda (Mira) complex during the asymmetric division of Drosophila neuroblasts (NBs) is yet to be fully understood. We have identified conserved Phosphotyrosyl phosphatase activator (PTPA) as a novel medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::606f6325b80c098a0bae49816dcc373b
https://pubmed.ncbi.nlm.nih.gov/26586222
https://pubmed.ncbi.nlm.nih.gov/26586222