Zobrazeno 1 - 10
of 34
pro vyhledávání: '"W Glenn McGregor"'
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39596 (2012)
Y-family DNA-polymerases have larger active sites that can accommodate bulky DNA adducts allowing them to bypass these lesions during replication. One member, polymerase eta (pol eta), is specialized for the bypass of UV-induced thymidine-thymidine d
Externí odkaz:
https://doaj.org/article/1a48da194ab641dab5e8a7eda2f340b7
Autor:
Ming-Lang Zhao, Janssen Daly, Danielle L. Watt, Marilyn Diaz, Thomas A. Kunkel, Madhumita Ray, Katarzyna Bebenek, Kathleen Richter, Chuancang Jiang, W. Glenn McGregor
Publikováno v:
The Journal of Immunology. 188:5528-5537
To test the hypothesis that DNA polymerase ζ participates in Ig hypermutation, we generated two mouse models of Pol ζ function: a B cell-specific conditional knockout and a knock-in strain with a Pol ζ mutagenesis-enhancing mutation. Pol ζ-defici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05e836bb600ad90d6104c289539abea
https://doi.org/10.4049/jimmunol.1102629
https://doi.org/10.4049/jimmunol.1102629
Autor:
Kristin J. Metry, J. Christopher States, W. Glenn McGregor, Mark A. Doll, David W. Hein, William M. Pierce, Jason R. Neale, Shuang Zhao
Publikováno v:
Molecular Carcinogenesis. 46:553-563
Heterocyclic amine carcinogens such as 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP) are present in diet and cigarette smoke. Bioactivation in humans includes N-hydroxylation catalyzed by cytochrome P4501A2 possibly followed by O-acetylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af83f3ac2718cd90b8dd54e5e7ade61e
https://doi.org/10.1002/mc.20302
https://doi.org/10.1002/mc.20302
Publikováno v:
Cancer Letters. 241:13-22
Mutations in DNA are generally considered to have an etiologic role in the development of cancer. If so, it follows that reducing the frequency of such mutations will reduce the incidence of cancer induced by mutagens. Recent advances in elucidating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd8c80862749c0d9b6566c5a49a4652f
https://doi.org/10.1016/j.canlet.2005.10.013
https://doi.org/10.1016/j.canlet.2005.10.013
Autor:
John O. Trent, Shelia D. Thomas, Fofi Hamhouyia, Donald M. Miller, Tom J. Burke, W. Glenn McGregor, Paula J. Bates, Allicia C. Girvan, Xiaohua Xu
Publikováno v:
Journal of Biological Chemistry. 276:43221-43230
The discovery of G-rich oligonucleotides (GROs) that have non-antisense antiproliferative activity against a number of cancer cell lines has been recently described. This biological activity of GROs was found to be associated with their ability to fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c11e6ef781ac512637d19750732016b
https://doi.org/10.1074/jbc.m104446200
https://doi.org/10.1074/jbc.m104446200
Publikováno v:
Mutation Research/DNA Repair. 461:163-167
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::020584eee610b46cde67151734f8a907
https://doi.org/10.1016/s0921-8777(00)00045-8
https://doi.org/10.1016/s0921-8777(00)00045-8
Autor:
W. Glenn McGregor
Publikováno v:
Journal of Investigative Dermatology Symposium Proceedings. 4(1):1-5
Cells that have been irradiated with ultraviolet light (UV) suffer damage to their DNA, primarily in the form of covalent linkage between adjacent pyrimidines. Such photoproducts represent blocks to RNA and DNA polymerases and are potentially mutagen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6049024b2c9570d8ba44f3a0163ba7
Publikováno v:
Molecular and Cellular Biology. 19:147-154
Xeroderma pigmentosum (XP) is a rare genetic disease characterized by a greatly increased susceptibility to sunlight-induced skin cancer. Cells from the majority of patients are defective in nucleotide excision repair. However, cells from one set of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb824c4ecc2cc5869b059984372d431a
https://doi.org/10.1128/mcb.19.1.147
https://doi.org/10.1128/mcb.19.1.147
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 376:143-152
The cytotoxic and mutagenic effect of 1-nitrosopyrene (1-NOP) and N -acetoxy-2-acetylaminofluorene (N-AcO-AAF) were compared with that of (±)-7β,8α-dihydroxy-9α,10-epoxy-7,8,9,10-tetrahydrobenzo[ a ]pyrene (BPDE) as a function of the initial freq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e58327c0992a6e26b0a29de538e34749
https://doi.org/10.1016/s0027-5107(97)00037-7
https://doi.org/10.1016/s0027-5107(97)00037-7
Publikováno v:
Mutation Research/DNA Repair. 362:65-74
Xeroderma pigmentosum (XP) variant patients are genetically predisposed to sunlight-induced skin cancer. Fibroblasts from such patients are extremely sensitive to mutations induced by UV radiation, and the spectrum of mutations induced in their hypox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2525c909252cb516e97915f5b4422a4c
https://doi.org/10.1016/0921-8777(95)00034-8
https://doi.org/10.1016/0921-8777(95)00034-8