Zobrazeno 1 - 10
of 114
pro vyhledávání: '"W Glen Pyle"'
Autor:
Julia E. Niskanen, Åsa Ohlsson, Ingrid Ljungvall, Michaela Drögemüller, Robert F. Ernst, Dennis Dooijes, Hanneke W. M. van Deutekom, J. Peter van Tintelen, Christian J. B. Snijders Blok, Marion van Vugt, Jessica van Setten, Folkert W. Asselbergs, Aleksandra Domanjko Petrič, Milla Salonen, Sruthi Hundi, Matthias Hörtenhuber, DoGA consortium, Juha Kere, W. Glen Pyle, Jonas Donner, Alex V. Postma, Tosso Leeb, Göran Andersson, Marjo K. Hytönen, Jens Häggström, Maria Wiberg, Jana Friederich, Jenny Eberhard, Magdalena Harakalova, Frank G. van Steenbeek, Gerhard Wess, Hannes Lohi
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-21 (2023)
Abstract Background Dilated cardiomyopathy (DCM) is a life-threatening heart disease and a common cause of heart failure due to systolic dysfunction and subsequent left or biventricular dilatation. A significant number of cases have a genetic etiolog
Externí odkaz:
https://doaj.org/article/49a1dbcf15a6421cbf422ecc2a464ea9
Publikováno v:
Biomolecules, Vol 14, Iss 6, p 675 (2024)
Risk of cardiovascular disease mortality rises in women after menopause. While increased cardiovascular risk is largely attributed to postmenopausal declines in estrogens, the molecular changes in the heart that contribute to risk are poorly understo
Externí odkaz:
https://doaj.org/article/7a7e5f88eb664a5f8baf35f1a8a0b9f4
Autor:
Shuang Zheng, Weijiang Tan, Xiang Li, Lijing Wang, Caiyi Zhu, W. Glen Pyle, Jianxin Chen, Jian Wu, Xuecong Ren, Honghua Chen, Yunzeng Zou, Peter H. Backx, Feng Hua Yang
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: While the protective effects of n-3 polyunsaturated fatty acids (PUFAs) on cardiac ischemia-reperfusion (IR) injury have been previously reported, limited data are available regarding how these fatty acids affect membrane receptors and th
Externí odkaz:
https://doaj.org/article/2ee3dbf4f3ac48d49e42d5c5ad7ce9ee
Autor:
Cristine J. Reitz, Mina Rasouli, Faisal J. Alibhai, Tarak N. Khatua, W. Glen Pyle, Tami A. Martino
Publikováno v:
JCI Insight, Vol 7, Iss 22 (2022)
Rest has long been considered beneficial to patient healing; however, remarkably, there are no evidence-based experimental models determining how it benefits disease outcomes. Here, we created an experimental rest model in mice that briefly extends t
Externí odkaz:
https://doaj.org/article/64875c6d784c47ff8dab25a049bbff50
Autor:
Xiang Li, Weijiang Tan, Shuang Zheng, W. Glen Pyle, Caiyi Zhu, Honghua Chen, Le Kang, Jian Wu, Yunzeng Zou, Peter H. Backx, Feng Hua Yang
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
BackgroundThe murine transverse aortic constriction (TAC) model is frequently used to investigate molecular mechanisms underlying heart failure. However, limited data is available regarding the expression of mRNAs and circRNAs in murine heart failure
Externí odkaz:
https://doaj.org/article/1911f8d3a5a349f8a989e6f87a493f41
Autor:
Xiang Li, Weijiang Tan, Shuang Zheng, Junjie Zhang, Caiyi Zhu, Chun Cai, Honghua Chen, Chenqi Yang, Le Kang, Zhanhong Pan, W. Glen Pyle, Peter H. Backx, Yunzeng Zou, Feng Hua Yang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2022)
Background: Pressure overload can result in dilated cardiomyopathy. The beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFAs) on heart disorders have been widely recognized. However, the molecular mechanisms underlying their protective ef
Externí odkaz:
https://doaj.org/article/519c8d8a11a44eafbd327a1181e94377
Autor:
Weijiang Tan, Xiang Li, Shuang Zheng, Xiaohui Li, Xiaoshen Zhang, W. Glen Pyle, Honghua Chen, Jian Wu, Huan Sun, Yunzeng Zou, Peter H. Backx, Feng Hua Yang
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Heart failure is induced by multiple pathological mechanisms, and current therapies are ineffective against heart failure with preserved ejection fraction (HFpEF). As there are limited animal models of HFpEF, its underlying mechanisms have not yet be
Externí odkaz:
https://doaj.org/article/6c41cbc59cf34331873bd66ca81280a6
Autor:
Xiang Li, Shuang Zheng, Weijiang Tan, Hongqi Chen, Xiaohui Li, Jian Wu, Ting Luo, Xuecong Ren, W. Glen Pyle, Lijing Wang, Peter H. Backx, Ren Huang, Feng Hua Yang
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
BackgroundThe secreted glycoprotein Slit2, previously known as an axon guidance cue, has recently been found to protect tissues in pathological conditions; however, it is unknown whether Slit2 functions in cardiac ischemia–reperfusion (IR) injury.M
Externí odkaz:
https://doaj.org/article/f7813434041a4dc6a4c2ebd9e1db16e3
Autor:
Vaibhav B. Patel, Pavel Zhabyeyev, Xueyi Chen, Faqi Wang, Manish Paul, Dong Fan, Brent A. McLean, Ratnadeep Basu, Pu Zhang, Saumya Shah, John F. Dawson, W. Glen Pyle, Mousumi Hazra, Zamaneh Kassiri, Saugata Hazra, Bart Vanhaesebroeck, Christopher A. McCulloch, Gavin Y. Oudit
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Gelsolin is an actin severing and capping protein that regulates cytoskeletal remodeling. Here the authors show that gelsolin is negatively regulated in the heart by PI3Kα‐ generated PIP3, and that loss of gelsolin activity prevents adverse cytosk
Externí odkaz:
https://doaj.org/article/e70a2475a25a49f6b0fbaaaa812f41c8
ObjectiveMenopause is associated with impairments in muscle contractile function. The temporal and mechanistic basis of this dysfunction are not known. Using a mouse model of menopause we identified how gradual ovarian failure affects single muscle f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2fa71a8b3f7a0568cd93675f39b93a2
https://doi.org/10.1101/2023.04.03.535419
https://doi.org/10.1101/2023.04.03.535419
