Zobrazeno 1 - 10
of 190
pro vyhledávání: '"W Gibson Wood"'
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e75654 (2013)
Pipoxolan (PIPO) has anti-spasmodic effects, and it is used clinically to relieve smooth muscle spasms. Cerebrovascular disease is one of the leading causes of disability and death worldwide. The main aim of this study was to investigate the effects
Externí odkaz:
https://doaj.org/article/c59a6443486d45ba9f27faddca28da1f
Autor:
Yan He, Jiankun Cui, James C-M Lee, Shinghua Ding, Malgorzata Chalimoniuk, Agnes Simonyi, Albert Y Sun, Zezong Gu, Gary A Weisman, W Gibson Wood, Grace Y Sun
Publikováno v:
ASN Neuro, Vol 3 (2011)
Excessive production of Aβ (amyloid β-peptide) has been shown to play an important role in the pathogenesis of AD (Alzheimer's disease). Although not yet well understood, aggregation of Aβ is known to cause toxicity to neurons. Our recent study de
Externí odkaz:
https://doaj.org/article/838fb7eb8de94b76a585fa948a4110d5
Publikováno v:
Neuromolecular Medicine
Synaptic impairment may be the main cause of cognitive dysfunction in brain aging that is probably due to a reduction in synaptic contact between the axonal buttons and dendritic spines. Rho proteins including the small GTPase Rac1 have become key re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35639b63618ab92744720b84ca260328
https://doi.org/10.1007/s12017-020-08640-0
https://doi.org/10.1007/s12017-020-08640-0
Autor:
Gunter P. Eckert, Gero P. Hooff, Dana M. Strandjord, Urule Igbavboa, Dietrich A. Volmer, Walter E. Müller, W. Gibson Wood
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 2, Pp 251-257 (2009)
Post-translational modification of small GTPases by farnesyl- (FPP) and geranylgeranylpyrophosphate (GGPP) has generated much attention due to their potential contribution to cancer, cardiovascular and neurodegenerative diseases. Prenylated proteins
Externí odkaz:
https://doaj.org/article/df1568d819044ae8b23e59ecfa9a12a3
Autor:
Cornelia Franke, Michael Nöldner, Reham Abdel-Kader, Leslie N. Johnson-Anuna, W. Gibson Wood, Walter E. Müller, Gunter P. Eckert
Publikováno v:
Neurobiology of Disease, Vol 25, Iss 2, Pp 438-445 (2007)
The present study determined if chronic simvastatin administration in vivo would provide neuroprotection in brain cells isolated from guinea pigs after challenge with the Bcl-2 inhibitor HA 14-1 or the NO donor sodium nitroprusside (SNP). Bcl-2 level
Externí odkaz:
https://doaj.org/article/e09ff3bd71e34308aac6230501252a7a
Autor:
Ming Ming Lee, W. Gibson Wood, Yuk Man Leung, Yu Wen Wang, Huei Yann Tsai, Wei-Shih Huang, Yuh-Fung Chen
Publikováno v:
NeuroMolecular Medicine. 18:322-333
Trans-cinnamaldehyde (TCA), an essential oil in cinnamon powder, may have beneficial effects as a treatment for stroke which is the second leading cause of death worldwide. Post-ischemic inflammation induces neuronal cell damage after stroke, and act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9059281a674d73c15200b00a2da3975
https://doi.org/10.1007/s12017-016-8395-9
https://doi.org/10.1007/s12017-016-8395-9
Publikováno v:
Critical reviews in biochemistry and molecular biology. 53(3)
The mevalonate-isoprenoid-cholesterol biosynthesis pathway plays a key role in human health and disease. The importance of this pathway is underscored by the discovery that two major isoprenoids, farnesyl and geranylgeranyl pyrophosphate, are require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad82350502925853d51af0739eb373fa
https://pubmed.ncbi.nlm.nih.gov/29718780
https://pubmed.ncbi.nlm.nih.gov/29718780
Autor:
Ya Yin Chen, Sakae Amagaya, Shinji Funayana, Jing Gung Chung, Chao Lin Kuo, An Cheng Huang, W. Gibson Wood, Jiun Long Yang, Shu Jen Chang, Shu Chun Hsu, Jin-Cherng Lien
Publikováno v:
Environmental Toxicology. 31:1600-1611
Prostate cancer is the most frequently diagnosed malignancy in men and the second highest contributor of male cancer mortality. The crude extract of Euphorbia formosana (CEEF) has been used for treatment of different diseases but the cytotoxic effect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bc69e040fbf4dec8bf9fa89a1f6a915
https://doi.org/10.1002/tox.22164
https://doi.org/10.1002/tox.22164
Autor:
W. Gibson Wood, Wen Chung Lin, Yueh-Hsiung Kuo, Wen Tsong Hsieh, Hui-Yi Lin, Jing Gung Chung, Hsu Feng Lu, Jou Hsuan Chen
Publikováno v:
Environmental Toxicology. 30:1205-1215
Latex of Euphorbia antiquorum (EA) has demonstrated great chemotherapeutic potential for cancer. However, the mechanisms of anti-proliferation of EA on cancer cell remain to be further investigated. The purpose of this study was to explore the influe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0de9e31458ca58eff03b01c9f9663cc7
https://doi.org/10.1002/tox.21992
https://doi.org/10.1002/tox.21992
Publikováno v:
Molecular Neurobiology. 50:214-220
Statins are attracting great interest albeit with some controversy in treating certain neurodegenerative diseases such as Alzheimer disease, Parkinson disease, multiple sclerosis, ischemic stroke, and traumatic brain injury. Support for the use of st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ba521af93cbbe9b1a25d5e2f4619a8
https://doi.org/10.1007/s12035-014-8647-3
https://doi.org/10.1007/s12035-014-8647-3