Targeting BRIX1 via Engineered Exosomes Induces Nucleolar Stress to Suppress Cancer Progression.

Autor: Gan Y; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China., Hao Q; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China., Han T; Institutes of Health Central Plains, Xinxiang Key laboratory for Molecular Oncology, Xinxiang Medical University, Xinxiang, Henan, 453003, P. R. China., Tong J; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China., Yan Q; Institutes of Health Central Plains, Xinxiang Key laboratory for Molecular Oncology, Xinxiang Medical University, Xinxiang, Henan, 453003, P. R. China., Zhong H; Department of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, P. R. China.; Jiangxi Key Laboratory for Individual Cancer Therapy, Nanchang, Jiangxi, 330006, P. R. China., Gao B; Umibio Co. Ltd., Shanghai, 201210, P. R. China., Li Y; Umibio Co. Ltd., Shanghai, 201210, P. R. China., Xuan Z; Umibio Co. Ltd., Shanghai, 201210, P. R. China., Li P; Laboratory of Animal Center, Medical Experiment Center, Shaanxi University of Chinese Medicine, Xianyang, 712046, P. R. China., Yao L; Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, P. R. China., Xu Y; Department of Breast Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, 110001, P. R. China., Jiang YZ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China., Shao ZM; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China., Deng J; Department of Oncology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, P. R. China.; Jiangxi Key Laboratory for Individual Cancer Therapy, Nanchang, Jiangxi, 330006, P. R. China., Chen J; Department of Physiology, School of Basic Medical Sciences, Jiangxi Medical College, Nanchang University, Nanchang, 330006, P. R. China., Zhou X; Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, P. R. China.; Key Laboratory of Breast Cancer in Shanghai, Department of Breast Surgery, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.; Shanghai Key Laboratory of Medical Epigenetics, International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology), Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, P. R. China.

Publikováno v: Advanced science (Weinheim, Baden-Wurttemberg, Germany) [Adv Sci (Weinh)] 2024 Oct 30, pp. e2407370. Date of Electronic Publication: 2024 Oct 30.

Differential infection of CD34+ cell-derived dendritic cells and monocytes with lymphocyte-tropic and monocyte-tropic HIV-1 strains

Autor: M K Warren, W L Rose, J L Cone, W G Rice, J A Turpin

Publikováno v: The Journal of Immunology. 158:5035-5042

Monocytes and dendritic cells are infected by HIV-1 and subsequently produce virions that initiate further rounds of infection. Current methods for the isolation and study of dendritic cells are hampered by the low frequency of these cells and contam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3c1d931f731b5ed2ba9604c50cb9eaa
https://doi.org/10.4049/jimmunol.158.10.5035

Cosalane Analogs with Enhanced Potencies as Inhibitors of HIV-1 Protease and Integrase

Autor: D. Reymen, Abhijit Mazumder, Lisa Graham, E. De Clercq, Yves Pommier, W. G. Rice, W. M. Golebiewski, Mark Cushman

Publikováno v: Journal of Medicinal Chemistry. 38:443-452

Several new analogues of the novel anti-HIV agent cosalane have been synthesized and evaluated as inhibitors of HIV-1 integrase and protease, HIV-1 replication, HIV-1 and HIV-2 cytopathicity, HIV-1- and HIV-2-mediated syncytium formation, and cytopat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54765ec21db40855df01f339b35aa4da
https://doi.org/10.1021/jm00003a007

ChemInform Abstract: Synthesis and Biological Evaluation of Certain Alkenyldiarylmethanes as Anti-HIV-1 Agents Which Act as Non-Nucleoside Reverse Transcriptase Inhibitors

Autor: L. Graham, V. Fliakas-Boltz, Mark Cushman, W. G. Rice, W. M. Golebiewski, Jim A. Turpin, R. W. Jun. Buckheit

Publikováno v: ChemInform. 27

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f89546161d19ea0c0ca5d8fd7853cf8
https://doi.org/10.1002/chin.199648103

ChemInform Abstract: Synthesis of a Cosalane Analogue with an Extended Polyanionic Pharmacophore Conferring Enhanced Potency as an anti-HIV Agent

Autor: C. A. Schaeffer, Jeffrey A. Ruell, Mark Cushman, Shabana Insaf, W. G. Rice

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7915ea10d2c9a432435bfeae3282c07
https://doi.org/10.1002/chin.199830217