Zobrazeno 1 - 10
of 38
pro vyhledávání: '"W G, Stillwell"'
Autor:
Roger A. Jones, Feng Gu, W. G. Stillwell, Anthony J. Shallop, John S. Wishnok, Steven R. Tannenbaum
Publikováno v:
Biochemistry. 41:7508-7518
Peroxynitrite is a strong oxidizing agent that is formed in the reaction of nitric oxide and superoxide anion. It is capable of oxidizing and nitrating a variety of biological targets including DNA, and these modifications may be responsible for a nu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454dc0911ffb740cc52da9d6e3263aed
https://doi.org/10.1021/bi020148q
https://doi.org/10.1021/bi020148q
Publikováno v:
Toxicology and Applied Pharmacology. 135:156-162
The formation of adducts between methyltetrahydrophthalic anhydride (MTHPA), an important industrial chemical and potent allergen, and collagen from guinea pig lung tissue was investigated. Collagen peptides were obtained from the lung tissue by homo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0c3ca2e42afd99214d955041a51987
https://doi.org/10.1006/taap.1995.1218
https://doi.org/10.1006/taap.1995.1218
Autor:
Koli Taghizadeh, W. G. Stillwell, Billy W. Day, John S. Wishnok, Steven R. Tannenbaum, Paul L. Skipper
Publikováno v:
Environmental Health Perspectives
Analysis of the types of protein adducts formed by chemical carcinogens indicate that adducts may be categorized into various classes according to the nature of the carcinogen as well as the amino acid with which they react. Tryptophan(214) of serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9f3c3f6a0c903e5ee7b3efb226b61f9
https://doi.org/10.1289/ehp.939951
https://doi.org/10.1289/ehp.939951
Publikováno v:
Environmental Health Perspectives
Investigation of urinary markers as indices of endogenous nitrosation and of gastric cancer etiology has been a major focus of our work. As part of this effort, studies have been carried out on a Colombian population at high risk for gastric cancer.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ee9b6016e662de5da110346f95ed2d
http://europepmc.org/articles/PMC1567041
http://europepmc.org/articles/PMC1567041
Publikováno v:
Carcinogenesis. 23(5)
2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a mutagenic and carcinogenic heterocyclic aromatic amine formed in meat products during cooking. The genotoxity of PhIP requires an initial cytochrome P450-mediated N-oxidation followed by N-O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c19bdfbd9761d8deb5924daa485e591
https://pubmed.ncbi.nlm.nih.gov/12016157
https://pubmed.ncbi.nlm.nih.gov/12016157
Publikováno v:
Cancer research. 59(20)
2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx), a major heterocyclic aromatic amine (HAA) formed in cooked meats, is metabolically transformed to mutagenic/carcinogenic intermediates. Cytochrome P4501A2 (CYP1A2)-mediated N-hydroxylation follow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a823503abf36b4c9fe14f1d688ee6f7
https://pubmed.ncbi.nlm.nih.gov/10537291
https://pubmed.ncbi.nlm.nih.gov/10537291
Publikováno v:
Cancer letters. 143(2)
Human exposure to heterocyclic aromatic amines such as MeIQx (2-amino-3,8-dimethylimidazo[4,5- f ]quinoxaline) may be monitored by measuring the levels of the heterocyclic aromatic amine in urine. In order to investigate the contribution of N -oxidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b48c4b0223b042ad162abce80123acf1
https://pubmed.ncbi.nlm.nih.gov/10503894
https://pubmed.ncbi.nlm.nih.gov/10503894
Autor:
L C, Kidd, W G, Stillwell, M C, Yu, J S, Wishnok, P L, Skipper, R K, Ross, B E, Henderson, S R, Tannenbaum
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 8(5)
Meats, such as beef, pork, poultry, and fish, cooked at high temperatures produce heterocyclic aromatic amines, which have been implicated indirectly as etiological agents involved in colorectal and other cancers in humans. This study examined the ur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b64663a14de3eef70be85f73326f0fa8
https://pubmed.ncbi.nlm.nih.gov/10815701
https://pubmed.ncbi.nlm.nih.gov/10815701
Publikováno v:
Cancer research. 57(16)
Cooking meat, fish, or poultry at high temperature gives rise to heterocyclic aromatic amines (HAAs), which may be metabolically activated to mutagenic or carcinogenic intermediates. The enzymes cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::daaa4f2f69aeaef0b4b803d89ed7812c
https://pubmed.ncbi.nlm.nih.gov/9270013
https://pubmed.ncbi.nlm.nih.gov/9270013
Autor:
S R, Tannenbaum, W G, Stillwell, H, Ji, P L, Skipper, M C, Yu, R K, Ross, B E, Henderson, R J, Turesky, G A, Gross
Publikováno v:
Princess Takamatsu symposia. 23
The metabolism of the heterocyclic amines has been extensively studied in rodents and limited studies have been conducted in nonhuman primates. A study has been undertaken on the metabolism of 2-amino-3,8-dimethylimadazo[4,5-f]quinoxaline (MeIQx) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b457f6fe0233669306c8443bee88bd93
https://pubmed.ncbi.nlm.nih.gov/8844811
https://pubmed.ncbi.nlm.nih.gov/8844811