Zobrazeno 1 - 10
of 42
pro vyhledávání: '"W G, Robison"'
Publikováno v:
Journal of biomedical optics. 1(3)
Rat lenses incubated in dimethyl sulfoxide (DMSO)‐water binary mixtures of different compositions became turbid. A slight haziness developed up to 0.062 mole fraction of DMSO; at higher concentrations dense turbidity developed. Microscopic examinat
Publikováno v:
Experimental Eye Research. 50:641-646
Previous evidence has shown clearly that sugar cataract formation results from unusually high intracellular levels of polyol. Documentation of polyol-related histological changes in the cortical fiber cells of the equatorial zone has been extensive.
Autor:
J, Piatigorsky, Z, Kozmik, J, Horwitz, L, Ding, E, Carosa, W G, Robison, P J, Steinbach, E R, Tamm
Publikováno v:
The Journal of biological chemistry. 275(52)
While many of the diverse crystallins of the transparent lens of vertebrates are related or identical to metabolic enzymes, much less is known about the lens crystallins of invertebrates. Here we investigate the complex eye of scallops. Electron micr
Publikováno v:
Investigative ophthalmologyvisual science. 41(8)
Previous studies have suggested that disturbances in plasminogen activator inhibitor (PAI)-1 may be relevant to the development of diabetic microvascular complications. To determine whether overexpression of PAI-1 in cells of retinal microvasculature
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 16(2)
It has been proposed that oxidative tissue damage is involved in the development of diabetic angiopathies. To evaluate this hypothesis, experiments were conducted to identify the retinal vessel changes induced by the oxidative stress related to alpha
Publikováno v:
Investigative ophthalmologyvisual science. 39(10)
To determine whether the diabetic-like thickening of retinal capillary basement membrane (RCBM) that develops in the galactose-fed rat model of diabetic ocular complications could be halted or ameliorated after 4 or 8 months of galactosemia by treatm
Publikováno v:
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 14(2)
This study investigated whether diabetic-like corneal sensory deficits occur in the galactose-fed rat model of diabetic ocular complications and if such deficits could be prevented using either of two structurally different aldose reductase (AR) inhi
Publikováno v:
Investigative ophthalmologyvisual science. 38(6)
To determine whether the diabeticlike retinal microangiopathies of the galactose-fed rat model could be ameliorated if intervention by withdrawal of the galactose diet or treatment with the aldose reductase inhibitor AL-3152 was initiated after quant
Publikováno v:
Journal of anatomy. 188
The purpose of the present study was to determine if prolonged systemic arterial administration of basic fibroblast growth factor (bFGF) at a dose sufficient to enhance collateral vessel formation in the ischaemic hearts of dogs would produce retinal
Publikováno v:
Investigative ophthalmologyvisual science. 36(12)
To determine if the retinal microangiopathies of the galactose-fed rat model of diabetic retinopathy can be prevented with the aldose reductase inhibitor sorbinil.Sprague-Dawley rats were fed 50% d-galactose with or without sorbinil (0.05% wt/wt), mi