Zobrazeno 1 - 10 of 35 pro vyhledávání: '"W G, Rice"'
1
New Alkenyldiarylmethanes with Enhanced Potencies as Anti-HIV Agents Which Act as Non-Nucleoside Reverse Transcriptase Inhibitors
Autor: Jeffrey A. Ruell, Mark Cushman, W. G. Rice, Catherine A. Schaeffer, Elzbieta Hejchman, Robert W. Buckheit, Mingjun Huang, Agustin Casimiro-Garcia, Karen Williamson
Publikováno v: Journal of Medicinal Chemistry. 41:2076-2089
Twenty-two new alkenyldiarylmethanes (ADAMs) were synthesized and evaluated for inhibition of HIV-1 replication. The most potent compound proved to be methyl 3',3"-dichloro-4',4"-dimethoxy-5', 5"-bis(methoxycarbonyl)-6,6-diphenyl-5-hexenoate (ADAM II
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29e5c9eea97150b26036bb82bd38834
https://doi.org/10.1021/jm9800595
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2
Differential infection of CD34+ cell-derived dendritic cells and monocytes with lymphocyte-tropic and monocyte-tropic HIV-1 strains
Autor: M K Warren, W L Rose, J L Cone, W G Rice, J A Turpin
Publikováno v: The Journal of Immunology. 158:5035-5042
Monocytes and dendritic cells are infected by HIV-1 and subsequently produce virions that initiate further rounds of infection. Current methods for the isolation and study of dendritic cells are hampered by the low frequency of these cells and contam
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3c1d931f731b5ed2ba9604c50cb9eaa
https://doi.org/10.4049/jimmunol.158.10.5035
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4
Cosalane Analogs with Enhanced Potencies as Inhibitors of HIV-1 Protease and Integrase
Autor: D. Reymen, Abhijit Mazumder, Lisa Graham, E. De Clercq, Yves Pommier, W. G. Rice, W. M. Golebiewski, Mark Cushman
Publikováno v: Journal of Medicinal Chemistry. 38:443-452
Several new analogues of the novel anti-HIV agent cosalane have been synthesized and evaluated as inhibitors of HIV-1 integrase and protease, HIV-1 replication, HIV-1 and HIV-2 cytopathicity, HIV-1- and HIV-2-mediated syncytium formation, and cytopat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54765ec21db40855df01f339b35aa4da
https://doi.org/10.1021/jm00003a007
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10
Removal of zinc is required for processing of the mature nucleocapsid protein of human immunodeficiency virus, type 1, by the viral protease
Autor: Alan R. Kimmel, W G Rice, E Kun, Kazuyasu Sakaguchi, John M. Louis, Ewald M. Wondrak
Publikováno v: Journal of Biological Chemistry. 269:21948-21950
In human immunodeficiency virus, RNA selection and packaging during assembly involve the two retroviral-type fingers of the nucleocapsid protein that are held in a constrained configuration by coordinated zinc ions. In this report, we demonstrate tha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ee5a4d17cf3d3500bd1b736520e4a55f
https://doi.org/10.1016/s0021-9258(17)31739-8
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