Výsledky vyhledávání - "W G, Bornmann"

Immunization of metastatic breast cancer patients with a fully synthetic globo H conjugate: a phase I trial

Autor: T, Gilewski, G, Ragupathi, S, Bhuta, L J, Williams, C, Musselli, X F, Zhang, W G, Bornmann, M, Spassova, K P, Bencsath, K S, Panageas, J, Chin, C A, Hudis, L, Norton, A N, Houghton, P O, Livingston, S J, Danishefsky

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 98(6)

The carbohydrate antigen globo H commonly found on breast cancer cells is a potential target for vaccine therapy. The objectives of this trial were to determine the toxicity and immunogenicity of three synthetic globo H-keyhole limpet hemocyanin conj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ee54fea839d3753d4a686f92ca0620
https://pubmed.ncbi.nlm.nih.gov/11248068

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Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo

Autor: F M, Sirotnak, H G, Wendel, W G, Bornmann, W P, Tong, V A, Miller, H I, Scher, M G, Kris

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(9)

Earlier studies from this laboratory have shown that the uricosuric agent probenecid (PBCD) will inhibit the extrusion of folate analogues from tumor cells mediated by a plasma membrane ATPase resembling the canicular multispecific organic anion tran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c9efd8d222ecfcd08c163852daf018e4
https://pubmed.ncbi.nlm.nih.gov/10999764

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Bcl-2 protects against beta-lapachone-mediated caspase 3 activation and apoptosis in human myeloid leukemia (HL-60) cells

Autor: W. G. Bornmann, David A. Boothman, John J. Pink, Sarah M. Planchon, Shelly M. Wuerzberger-Davis, K. A. Robertson

Publikováno v: Oncology reports. 6(3)

We previously demonstrated that beta-lapachone (beta-lap) killed cancer cells solely by apoptosis. Beta-Lap induced apoptosis in HL-60 cells in a dose-dependent manner as measured by flow cytometry and DNA ladder formation. Cell cycle changes, such a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2df5be8ad3348dc49925380b5333cba
https://pubmed.ncbi.nlm.nih.gov/10203579

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Schedule-dependent synergism between raltitrexed and irinotecan in human colon cancer cells in vitro

Autor: C, Aschele, C, Baldo, A F, Sobrero, D, Debernardis, W G, Bornmann, J R, Bertino

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 4(5)

The quinazoline folate analogue raltitrexed (ZD1694; Tomudex) and the camptothecin derivative irinotecan are two new agents showing clinical activity against colorectal cancer. To identify the optimal conditions to achieve synergistic cytotoxicity be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::138111ebc03236416d40460981ca9285
https://pubmed.ncbi.nlm.nih.gov/9607593

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Induction of apoptosis in MCF-7:WS8 breast cancer cells by beta-lapachone

Autor: S M, Wuerzberger, J J, Pink, S M, Planchon, K L, Byers, W G, Bornmann, D A, Boothman

Publikováno v: Cancer research. 58(9)

Beta-lapachone (beta-lap) affects a number of enzymes in vitro, including type I topoisomerase (Topo I); however, its exact intracellular target(s) and mechanism of cell killing remain unknown. We compared the cytotoxic responses of MCF-7:WS8 (MCF-7)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ce8ccbdfda88af50ff874bce0e9f85f
https://pubmed.ncbi.nlm.nih.gov/9581828

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Inhibition of human immunodeficiency virus type 1 replication by 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-a]pyrazine, an in vivo metabolite of oltipraz

Autor: H J, Prochaska, W G, Bornmann, P, Baron, B, Polsky

Publikováno v: Molecular pharmacology. 48(1)

Oltipraz, an inhibitor of human immunodeficiency virus type 1 replication in vitro (ED50 approximately 10 microM), undergoes extensive metabolism in vivo. Most of the orally administered drug undergoes opening of the dithiolethione ring, reduction, r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7d6cd61a0c776ee906ca3d49aa0eabfb
https://pubmed.ncbi.nlm.nih.gov/7542738

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Bacterial lipopolysaccharide has structural similarity to ceramide and stimulates ceramide-activated protein kinase in myeloid cells

Autor: C K, Joseph, S D, Wright, W G, Bornmann, J T, Randolph, E R, Kumar, R, Bittman, J, Liu, R N, Kolesnick

Publikováno v: The Journal of biological chemistry. 269(26)

Bacterial lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha and interleukin-1 beta (IL-1 beta) stimulate similar cellular responses. TNF-alpha and IL-1 beta are known to initiate signaling through a pathway involving hydrolysis of sphingomy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2bf5d8ea069cecfbd88fe427100263b4
https://pubmed.ncbi.nlm.nih.gov/8021269

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