Zobrazeno 1 - 10
of 258
pro vyhledávání: '"W G, Beamer"'
Autor:
Gary A. Churchill, W. G. Beamer, Clifford J. Rosen, Ralph Müller, Toru Uchiyama, Kathryn L. Shultz, Mary L. Bouxsein, Saunak Sen, Charles H. Turner, Leah Rae Donahue
Publikováno v:
Journal of Bone and Mineral Research. 19:587-599
BMD, which reflects both cortical and cancellous bone, has been shown to be highly heritable; however, little is known about the specific genetic factors regulating trabecular bone. Genome-wide linkage analysis of vertebral trabecular bone traits in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052eb95c50a0f404b248d8854a600e05
https://doi.org/10.1359/jbmr.0301255
https://doi.org/10.1359/jbmr.0301255
Autor:
W. G. Beamer, Leah Rae Donahue, Daniel L. Koller, Tatiana Foroud, Qiwei Sun, Jennifer L. Schriefer, Charles H. Turner, Kathryn L. Shultz, Clifford J. Rosen
Publikováno v:
Journal of Bone and Mineral Research. 18:1758-1765
Genome-wide QTL analysis for bone density, structure, and biomechanical phenotypes was performed in 999 (B6xC3H)F2 mice. Multivariate phenotypes were also derived to test for pleiotropic QTL effects. Highly significant QTLs were detected with pleiotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2612d3823bfc395a390576290b4f0329
https://doi.org/10.1359/jbmr.2003.18.10.1758
https://doi.org/10.1359/jbmr.2003.18.10.1758
Autor:
Kathryn L. Shultz, Xin-Min Li, Clifford J. Rosen, Subburaman Mohan, Apurva K. Srivastava, Leah R. Donahae, Bouchra Edderkaoui, David J. Baylink, W. G. Beamer, William K.-H. Lau, Weikuan Gu
Publikováno v:
Functional & Integrative Genomics. 1:375-386
Peak bone density is an important determining factor of future osteoporosis risk. We previously identified a quantitative trait locus (QTL) that contributes significantly to high bone density on mouse chromosome 1 from a cross between C57BL/6J (B6) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887f05dd172a156c401919cfd9231e55
https://doi.org/10.1007/s10142-001-0042-2
https://doi.org/10.1007/s10142-001-0042-2
Publikováno v:
Osteoporosis International. 12:803-810
Very low bone mineral density (BMD) is now considered as diagnostic of osteoporosis. Moreover, many women who are osteopenic eventually develop osteoporotic fractures. Hence, bone density testing has occupied center stage in the diagnosis and treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df903b87c95e415fdeb69f1090f9b44
https://doi.org/10.1007/s001980170030
https://doi.org/10.1007/s001980170030
Autor:
C J, Rosen, G A, Churchill, L R, Donahue, K L, Shultz, J K, Burgess, D R, Powell, C, Ackert, W G, Beamer
Publikováno v:
Bone. 27:521-528
Serum insulin-like growth factor-1 (IGF-1) and femoral bone mineral density (BMD) differ between two inbred strains of mice, C3H/HeJ (C3H) and C57BL/6J (B6), by approximately 30% and 50%, respectively. Similarly, skeletal IGF-1 content, bone formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e51db92f8b2c0ea42f71302fe10bd032
https://doi.org/10.1016/s8756-3282(00)00354-9
https://doi.org/10.1016/s8756-3282(00)00354-9
Publikováno v:
Journal of Endocrinology. 139:431-439
Insulin-like growth factor-I (IGF-I) and testosterone are major hormonal regulators of protein metabolism. We chose genetically GH-deficient little (lit/lit) mice to test whether these anabolic hormones act independently or in concert with each other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b7d38eb34e0ff5f0f0c0fa25396cb27
https://doi.org/10.1677/joe.0.1390431
https://doi.org/10.1677/joe.0.1390431
Publikováno v:
Growth Hormone & IGF Research. 10:S103-S105
Summary Serum insulin-like growth factor I (IGF-I) is regulated by numerous variables, including growth hormone(GH), nutritional status, gonadal steroids and other hormones. However, the circulating IGF-I phenotype is also under heritable regulation,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::786b7ca3b5d1f624db34799ba5996178
https://doi.org/10.1016/s1096-6374(00)80019-2
https://doi.org/10.1016/s1096-6374(00)80019-2
Autor:
V E, DeMambro, D R, Clemmons, L G, Horton, M L, Bouxsein, T L, Wood, W G, Beamer, E, Canalis, C J, Rosen
IGF-binding protein-2 (IGFBP-2) is a 36-kDa protein that binds to the IGFs with high affinity. To determine its role in bone turnover, we compared Igfbp2(-/-) mice with Igfbp2(+/+) colony controls. Igfbp2(-/-) males had shorter femurs and were heavie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13d78d54f5218e69b9576c601b1be56b
Autor:
C H, Turner, W G, Beamer
Publikováno v:
Journal of musculoskeletalneuronal interactions. 2(3)
Studies of twins have established that peak bone mass is about 70% heritable. The skeletal response to exercise contributes to peak bone mass, as mechanical loading increases skeletal mass during growth and development. It is possible that the skelet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8bf99b63a731b5c49efda82adf63886
https://pubmed.ncbi.nlm.nih.gov/15758442
https://pubmed.ncbi.nlm.nih.gov/15758442
Publikováno v:
Journal of musculoskeletalneuronal interactions. 2(3)
The rationale for use of inbred strains of mice in bone research is well recognized and includes: a) practical factors (economics of scale, rapid development of adult status, pre-existing knowledge, down-sized technologies) and b) proven methodologie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::eb5907b0a4ca5e936b0a47ed31502ea7
https://pubmed.ncbi.nlm.nih.gov/15758440
https://pubmed.ncbi.nlm.nih.gov/15758440