Zobrazeno 1 - 10
of 26
pro vyhledávání: '"W F J van IJcken"'
Exploring the Interspecific Interactions and the Metabolome of the Soil Isolate Hylemonella gracilis
Autor:
Olaf Tyc, Purva Kulkarni, Adam Ossowicki, Vittorio Tracanna, Marnix H. Medema, Peter van Baarlen, W. F. J. van IJcken, Koen J. F. Verhoeven, Paolina Garbeva
Publikováno v:
mSystems, Vol 8, Iss 1 (2023)
ABSTRACT Microbial community analysis of aquatic environments showed that an important component of its microbial diversity consists of bacteria with cell sizes of ~0.1 μm. Such small bacteria can show genomic reductions and metabolic dependencies w
Externí odkaz:
https://doaj.org/article/a8e963bfcf3d4d83aa20e4b258c30feb
Autor:
J, Vos, H, Tejeda-Mora, A, Merino, L, Wu, W W, Woud, J A A, Demmers, W F J, van IJcken, M E J, Reinders, M J, Hoogduijn
Publikováno v:
Journal of Controlled Release, 350, 642-651. Elsevier
Vesicle-based medicines hold great promise for therapy development but essential knowledge on the bio-distribution and longevity of vesicles after administration is lacking. We generated vesicles from the membranes of human mesenchymal stromal cells
Autor:
Martijn P. Lolkema, Joost Gribnau, M. M. van der Put, Lindsay Angus, Zakia Azmani, Cees Verhoef, L. F. van Dessel, Stefan Sleijfer, Teoman Deger, Joachim Boers, Saskia M. Wilting, Ruben Boers, Dirk J. Grünhagen, V. de Weerd, Jwm Martens, W F J van IJcken
BackgroundDNA methylation detection in liquid biopsies provides a highly promising and much needed means for real-time monitoring of disease load in advanced cancer patient care. Compared to the often-used somatic mutations, tissue- and cancer-type s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::30269831b5e6d5ed57b19a7618da2814
https://doi.org/10.1101/2021.07.12.452012
https://doi.org/10.1101/2021.07.12.452012
Autor:
C.H.M. van Deurzen, R. van Marion, J. M. Martens, W. Dinjens, Niels M.G. Krol, W F J van IJcken, Rutger W W Brouwer, Shusma C. Doebar
Publikováno v:
Virchows Archiv
Virchows Archiv. An International Journal of Pathology, 474(2), 247-251. Springer-Verlag
Virchows Archiv. An International Journal of Pathology, 474(2), 247-251. Springer-Verlag
Several models have been described as potential mechanisms for the progression of ductal carcinoma in situ (DCIS) to invasive breast cancer (IBC). The aim of our study was to increase our understanding of DCIS progression by using massive parallel se
Autor:
W F J van IJcken, Thomas R. L. Klei, Sietse Q. Nagelkerke, Martijn Veldthuis, Benjamin Nota, R van Zwieten, J Dalimot, Frederik P. J. Mul, F P J van Alphen, T Rademakers, Edwin Oole, Alexander B. Meijer, Mark Hoogenboezem, Taco W. Kuijpers, Søren K. Moestrup, Pia Svendsen, R. van Bruggen
Publikováno v:
Klei, T R L, Dalimot, J, Nota, B, Veldthuis, M, Mul, F P J, Rademakers, T, Hoogenboezem, M, Nagelkerke, S Q, van IJcken, W F J, Oole, E, Svendsen, P, Moestrup, S K, van Alphen, F P J, Meijer, A B, Kuijpers, T W, van Zwieten, R & van Bruggen, R 2020, ' Hemolysis in the spleen drives erythrocyte turnover ', Blood, vol. 136, no. 14, pp. 1579-1589 . https://doi.org/10.1182/blood.2020005351
Blood, 136(14), 1579-1589. The American Society of Hematology
Blood, 136(14), 1579. Amer Soc Hematology
Blood, 136(14), 1579-1589. American Society of Hematology
Blood, 136(14), 1579-1589. The American Society of Hematology
Blood, 136(14), 1579. Amer Soc Hematology
Blood, 136(14), 1579-1589. American Society of Hematology
Red pulp macrophages (RPMs) of the spleen mediate turnover of billions of senescent erythrocytes per day. However, the molecular mechanisms involved in sequestration of senescent erythrocytes, their recognition, and their subsequent degradation by RP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35ab5a9fde47f37d72acf4e0a11838b
https://pure.au.dk/portal/da/publications/hemolysis-in-the-spleen-drives-erythrocyte-turnover(507ae87c-abcf-472f-8db3-ed1373f52970).html
https://pure.au.dk/portal/da/publications/hemolysis-in-the-spleen-drives-erythrocyte-turnover(507ae87c-abcf-472f-8db3-ed1373f52970).html
Autor:
A. de Klein, Katharina Biermann, Anja Wagner, W. Dinjens, R. van Marion, B. P. L. Wijnhoven, A. M. J. van Nistelrooij, J. J. B. van Lanschot, M C W Spaander, W F J van IJcken
Publikováno v:
Familial Cancer, 17(3), 435-440. Springer Netherlands
Familial Cancer
Familial Cancer
The vast majority of esophageal adenocarcinoma cases are sporadic and caused by somatic mutations. However, over the last decades several families have been identified with clustering of Barrett’s esophagus and esophageal adenocarcinoma. This obser
Autor:
B. Eussen, A. de Klein, Erwin Brosens, Rutger W W Brouwer, M C G N van den Hout, Christel E M Kockx, Frank Sleutels, W F J van IJcken
Publikováno v:
Bioinformatics
Bioinformatics, 34(16), 2732-2739. Oxford University Press
Bioinformatics, 34(16), 2732-2739. Oxford University Press
Motivation PCR-based DNA enrichment followed by massively parallel sequencing is a straightforward and cost effective method to sequence genes up to high depth. The full potential of amplicon-based sequencing assays is currently not achieved as analy
Autor:
Martine L.M. Lamfers, W F J van IJcken, Andrea Conidi, Rutger W W Brouwer, Danny Huylebroeck, Iris S.C. Verploegh, Sieger Leenstra
Publikováno v:
Neuro-Oncology. 23:ii18-ii18
BACKGROUND Glioblastoma (GBM) is the most aggressive primary brain tumor. The well-known cellular heterogeneity of this cancer, which includes glioma tumor-initiating cells with stem cell characteristics (GSCs), (co)influences therapy resistance and
Autor:
Jeffrey Stedehouder, Albert Hofman, W F J van IJcken, Harry L A Janssen, A.G. Uitterlinden, Rutger W W Brouwer, Henning Tiemeier, Robert Kraaij, C M van Duijn, F M S de Vrij, Najaf Amin, S. Darwish Murad, M C G N van den Hout, Johan M. Kros, Steven A. Kushner, M Baghdadi, O. Jovanova, J. van Rooij
Publikováno v:
Molecular Psychiatry, 23(5), 1120-1126. Nature Publishing Group
Molecular Psychiatry
Molecular Psychiatry
Depression is the most prevalent psychiatric disorder with a complex and elusive etiology that is moderately heritable. Identification of genes would greatly facilitate the elucidation of the biological mechanisms underlying depression, however, its
Autor:
Meike W. Vernooij, Henning Tiemeier, F M S de Vrij, W F J van IJcken, M. A. Ikram, Rutger W W Brouwer, Wiro J. Niessen, Robin P. Peeters, O. Jovanova, J. van Rooij, E. C. M. van Leeuwen, Layal Chaker, K. Willems van Dijk, Hieab H.H. Adams, Najaf Amin, C M van Duijn, Ayse Demirkan, Steven A. Kushner, S. J. van der Lee, André G. Uitterlinden, Robert Kraaij, Maryam Kavousi, Abbas Dehghan, Albert Hofman, Thomas Hankemeier, Oscar H. Franco
Publikováno v:
Molecular Psychiatry, 22(4), 537-543
Molecular Psychiatry, 22(4), 537-543. Nature Publishing Group
Amin, N, Jovanova, O, Adams, H H H, Dehghan, A, Kavousi, M, Vernooij, M W, Peeters, R P, De Vrij, F M S, Van Der Lee, S J, Van Rooij, J G J, Van Leeuwen, E M, Chaker, L, Demirkan, A, Hofman, A, Brouwer, R W W, Kraaij, R, Willems Van DIjk, K, Hankemeier, T, Van Ijcken, W F J, Uitterlinden, A G, Niessen, W J, Franco, O H, Kushner, S A, Ikram, M A, Tiemeier, H & Van Duijn, C M 2017, ' Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms ', Molecular Psychiatry, vol. 22, no. 4, pp. 537-543 . https://doi.org/10.1038/mp.2016.101
Molecular Psychiatry, 22(4), 537-543. Nature Publishing Group
Amin, N, Jovanova, O, Adams, H H H, Dehghan, A, Kavousi, M, Vernooij, M W, Peeters, R P, De Vrij, F M S, Van Der Lee, S J, Van Rooij, J G J, Van Leeuwen, E M, Chaker, L, Demirkan, A, Hofman, A, Brouwer, R W W, Kraaij, R, Willems Van DIjk, K, Hankemeier, T, Van Ijcken, W F J, Uitterlinden, A G, Niessen, W J, Franco, O H, Kushner, S A, Ikram, M A, Tiemeier, H & Van Duijn, C M 2017, ' Exome-sequencing in a large population-based study reveals a rare Asn396Ser variant in the LIPG gene associated with depressive symptoms ', Molecular Psychiatry, vol. 22, no. 4, pp. 537-543 . https://doi.org/10.1038/mp.2016.101
Despite a substantial genetic component, efforts to identify common genetic variation underlying depression have largely been unsuccessful. In the current study we aimed to identify rare genetic variants that might have large effects on depression in