Zobrazeno 1 - 10
of 44
pro vyhledávání: '"W F, Trager"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
Human liver microsomes catalyze the oxidation of sulfinpyrazone sulfide (SPZS) to a variable mixture of sulfinpyrazone (SPZ) enantiomers and two minor phenolic metabolites. In one, the thiophenyl ring is hydroxylated, whereas in the second an N-pheny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b254cbb09e6161b693e0255fad466fbc
https://pubmed.ncbi.nlm.nih.gov/11302937
https://pubmed.ncbi.nlm.nih.gov/11302937
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 27(12)
Nevirapine (NVP), a non-nucleoside inhibitor of HIV-1 reverse transcriptase, is concomitantly administered to patients with a variety of medications. To assess the potential for its involvement in drug interactions, cytochrome P-450 (CYP) reaction ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6629b920a0f8f1d2fca047eb271e1341
https://pubmed.ncbi.nlm.nih.gov/10570031
https://pubmed.ncbi.nlm.nih.gov/10570031
Publikováno v:
Biochemistry. 38(11)
Previous modeling efforts have suggested that coumarin ligand binding to CYP2C9 is dictated by electrostatic and pi-stacking interactions with complementary amino acids of the protein. In this study, analysis of a combined CoMFA-homology model for th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1585da90e4c72e95bee35ee56816aa92
https://pubmed.ncbi.nlm.nih.gov/10079071
https://pubmed.ncbi.nlm.nih.gov/10079071
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 26(7)
(R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 (CYP or P450) 2A6. Menthofuran caused a time- and concentration-dependent loss of CYP2A6 activity. The inactivation of CYP2A6 was characterized by a Ki of 2.5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::610bca625499414f48fb269184fa6db4
https://pubmed.ncbi.nlm.nih.gov/9660853
https://pubmed.ncbi.nlm.nih.gov/9660853
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 25(12)
The P450 2A6 catalyzed 7-hydroxylation of coumarin proceeded with a mean Km of 0.40 (+/-0.13) microM and Vmax of 6.34 nmol/nmol P450/min (36-fold variation) in microsomal preparations from a panel of 12 human livers. Substrate depletion was avoided d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6457c5e0aff8619e3bca04bac8c098ca
https://pubmed.ncbi.nlm.nih.gov/9394031
https://pubmed.ncbi.nlm.nih.gov/9394031
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(9)
The effect of branch pathways on the observed intramolecular isotope effect and deuterium retention associated with 6- and 7-hydroxylation of selectively monodeuterated (R)- and (S)-warfarin with cytochrome P450 (CYP) 2C9 and CYP1A2 were studied. cDN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::af46eb7adc778764a077702ab349294a
https://pubmed.ncbi.nlm.nih.gov/8886617
https://pubmed.ncbi.nlm.nih.gov/8886617
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(5)
Kinetic studies demonstrate that two forms of human liver cytochrome P450 are responsible for the formation of (R)-8-hydroxywarfarin: a low-affinity enzyme (KM approximately 1.5 mM), previously identified as P4501A2; and a high-affinity enzyme (KM =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33dbf88a6c27aba01e93d34288e7c3fc
https://pubmed.ncbi.nlm.nih.gov/8723744
https://pubmed.ncbi.nlm.nih.gov/8723744
Autor:
D J, Black, K L, Kunze, L C, Wienkers, B E, Gidal, T L, Seaton, N D, McDonnell, J S, Evans, J E, Bauwens, W F, Trager
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(4)
Consistent with expectations based on human in vitro microsomal experiments, administration of fluconazole (400 mg/day) for 6 days to six human volunteers significantly reduced the cytochrome P450 (P450)-dependent metabolic clearance of the warfarin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4856d1d501c512806cba1d22e667419
https://pubmed.ncbi.nlm.nih.gov/8801057
https://pubmed.ncbi.nlm.nih.gov/8801057
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(4)
The antifungal agent fluconazole was found to be a potent inhibitor of cytochrome P450 (P450) 2C9 (Ki = 7-8 microM), the principal enzyme responsible for the clearance (85%) of the more potent anticoagulant (S)-warfarin to the inactive (S)-7- and (S)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1afd5bfe9868126e0065c1132184ae68
https://pubmed.ncbi.nlm.nih.gov/8801056
https://pubmed.ncbi.nlm.nih.gov/8801056
Autor:
K L, Kunze, W F, Trager
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(4)
The results of studies of the effect of fluconazole on cytochrome P450 (P450) 2C9 activity in vivo and in vitro are used to develop an approach to the safe management of the warfarin-fluconazole drug interaction. This approach begins with a determina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d195227967817e2c5155bd27a67a92e
https://pubmed.ncbi.nlm.nih.gov/8801058
https://pubmed.ncbi.nlm.nih.gov/8801058