Zobrazeno 1 - 10
of 46
pro vyhledávání: '"W F, Hickey"'
Publikováno v:
Journal of Neuroscience Research. 45:747-757
The role of T cell activation associated adhesion molecules on lymphocyte traffic and the initiation of inflammation has received considerable attention. This study, using a new monoclonal antibody (mAb) TLD-3A12, describes the distribution of PECAM-
Publikováno v:
The Journal of Immunology. 156:4916-4924
B7-1 and B7-2 are well characterized costimulatory ligands on Ag presentation cells for the CD28 and CTLA4 receptors on T cells. The fusion protein CTLA4Ig can block this interaction and prevent specific T cell activation. The development of fatal CD
Publikováno v:
Glia. 14:257-266
Hematogenous macrophages are known to be involved in the induction of tissue damage in the central nervous system (CNS) as well as of clinical symptoms in experimental autoimmune encephalomyelitis (EAE). Although resident microglia can become phagocy
Publikováno v:
The Journal of Immunology. 154:4309-4321
Ramified microglia in the adult central nervous system (CNS) are the principal glial element up-regulating MHC class I and II expression in response to inflammatory events or neuronal damage. A proportion of these cells also express MHC class II cons
Publikováno v:
The Journal of Immunology. 153:3890-3898
To explore the mechanisms responsible for the development of tolerance to allografts after intrathymic (IT) injection of alloantigen, the well-defined model of experimental autoimmune encephalomyelitis (EAE), which mimics the human autoimmune disease
Publikováno v:
The Journal of Immunology. 153:901-909
Proteolipid apoprotein (PLP) is a major component of the central nervous system myelin. As such, it is capable of inducing experimental allergic encephalomyelitis (EAE) in many subhuman species. On the basis of a putative MHC class II binding motif i
Publikováno v:
The Journal of Immunology. 153:892-900
Cardiac myosin (CM) has been implicated as an autoantigen in the induction of experimental allergic myocarditis (EAM). At the present time no myocarditogenic peptides of CM have been identified. To identify CM peptides with myocarditogenic properties
Publikováno v:
The American journal of pathology. 157(6)
Co-localization of proteins and nucleic acid sequences by in situ hybridization and immunohistochemistry is frequently difficult as the process necessary to detect the target structure of one technique may negatively affect the target of the other. M
Autor:
W F, Hickey
Publikováno v:
Journal of neuroimmunology. 98(1)
In the century and a half since multiple sclerosis (MS) was first recognized, the pathology of the condition has been defined with increasing detail. From the recognition and definition of MS as a clinical phenomenon, studies of the diseased brain ti
Autor:
P M, Knopf, C J, Harling-Berg, H F, Cserr, D, Basu, E J, Sirulnick, S C, Nolan, J T, Park, G, Keir, E J, Thompson, W F, Hickey
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(2)
The intrathecal Ab response to Ag introduced into the normal brain has not been fully explored. Involvement of Ag-specific, peripheral B cells in an intrathecal response was studied using a normal rat model of Ag infusion through an indwelling cannul