Zobrazeno 1 - 10
of 35
pro vyhledávání: '"W F, Dove"'
Publikováno v:
The Journal of Cell Biology
Scopus-Elsevier
Scopus-Elsevier
Min is a fully penetrant dominant mutation that leads to the development of multiple intestinal adenomas throughout the duodenal-to-colonic axis. Min/+ C57BL6/J mice have an average life-span of 120 d. Multi-label immunocytochemical studies of these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8109f8cc98a9ae05d700ca78742c452f
http://europepmc.org/articles/PMC2289373
http://europepmc.org/articles/PMC2289373
Autor:
R T, Cormier, W F, Dove
Publikováno v:
Cancer research. 60(14)
Altered patterns of the 5-cytosine methylation of genomic DNA are associated with the development of a wide range of human cancers. We have studied the mechanisms and genetic pathways by which a targeted heterozygous deficiency in the murine 5-cytosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c25dcf51cba2612b26681de2b84b45dc
https://pubmed.ncbi.nlm.nih.gov/10919675
https://pubmed.ncbi.nlm.nih.gov/10919675
Publikováno v:
Cancer research. 57(10)
We have demonstrated previously that intestinal tumor formation in B6 Min/+ mice is always accompanied by loss of the wild-type adenomatous polyoposis coli (Apc) allele and that intestinal tumor multiplicity in B6 Min/+ mice can be significantly incr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c7d009f6ed323c86fed90f83dfb3ed5
https://pubmed.ncbi.nlm.nih.gov/9157997
https://pubmed.ncbi.nlm.nih.gov/9157997
Publikováno v:
Biochimica et biophysica acta. 1332(2)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::493343ecc1cd979a3264c3f0b3504b99
https://pubmed.ncbi.nlm.nih.gov/9141462
https://pubmed.ncbi.nlm.nih.gov/9141462
Autor:
W F, Dove, L, Clipson, K A, Gould, C, Luongo, D J, Marshall, A R, Moser, M A, Newton, R F, Jacoby
Publikováno v:
Cancer research. 57(5)
We have tested the hypothesis that enteric bacteria are necessary for formation of intestinal adenomas in C57BL/6-ApcMin/+ mouse. Germ-free mice developed 2-fold fewer adenomas than conventional controls in the medial small intestine (7.3 versus 14.9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::416222611596dee2b3c7ede1286096fb
https://pubmed.ncbi.nlm.nih.gov/9041176
https://pubmed.ncbi.nlm.nih.gov/9041176
Publikováno v:
Genes, chromosomescancer. 17(3)
We have found previously that all spontaneous intestinal adenomas from Apc+/ApcMin mice lose the wild type Apc marker on two genetic backgrounds. On the (AKR x B6)F1 background, this event involves loss of the entire homolog of mouse chromosome 18 ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d076aa9679a67e7a71e921eb9414aff8
https://pubmed.ncbi.nlm.nih.gov/8946200
https://pubmed.ncbi.nlm.nih.gov/8946200
Autor:
K A, Gould, W F, Dove
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 7(10)
Mice heterozygous for Min, a mutant allele of Apc, develop adenomas throughout the intestinal tract. Tumor multiplicity in Min mice is influenced by genetic modifier loci. Previously, we mapped one of these modifier loci, Mom1, to distal mouse chromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a48c4fba33e7b833f4e3c909a5470935
https://pubmed.ncbi.nlm.nih.gov/8891340
https://pubmed.ncbi.nlm.nih.gov/8891340
Autor:
Y, Beazer-Barclay, D B, Levy, A R, Moser, W F, Dove, S R, Hamilton, B, Vogelstein, K W, Kinzler
Publikováno v:
Carcinogenesis. 17(8)
The Min mouse provides a genetically defined model for inherited and sporadic forms of human colorectal tumorigenesis. To test the suitability of this model for the evaluation and optimization of chemopreventive agents, we examined the effects of sul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::37e8a914c78d1b506a806c065aac5e3e
https://pubmed.ncbi.nlm.nih.gov/8761438
https://pubmed.ncbi.nlm.nih.gov/8761438
Autor:
R F, Jacoby, D J, Marshall, M A, Newton, K, Novakovic, K, Tutsch, C E, Cole, R A, Lubet, G J, Kelloff, A, Verma, A R, Moser, W F, Dove
Publikováno v:
Cancer research. 56(4)
C57BL/6J-Min/+mice (n = 56), heterozygous for a nonsense mutation in the Apc gene, were randomized at weaning to seven groups, including groups treated with piroxicam at 0, 50, 100, and 200 ppm in the AIN93G diet. After only 6 weeks of treatment, int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2c48ec472c0456a5f11e15e2b3b442e5
https://pubmed.ncbi.nlm.nih.gov/8631000
https://pubmed.ncbi.nlm.nih.gov/8631000
Publikováno v:
Cancer research. 55(19)
The timing of intestinal tumor initiation in B6-Min/+ mice has been examined by treating mice at 5-35 days of age with a single i.p. injection of the direct-acting alkylating agent N-ethyl-N-nitrosourea (ENU). Treatment of Min/+ mice at 5-14 days of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9bb8f95b10f56bb3e36ef4a61e84648
https://pubmed.ncbi.nlm.nih.gov/7671263
https://pubmed.ncbi.nlm.nih.gov/7671263