Zobrazeno 1 - 10
of 395
pro vyhledávání: '"W E Van Nostrand"'
Publikováno v:
Neurodegenerative Diseases. 10:108-111
Background/Aims: There is increased amyloid-β protein precursor (AβPP) expression and amyloid-β protein (Aβ) production in the brain shortly following cerebral ischemic stroke in rodent models. It has been postulated that this may seed amyloid de
Publikováno v:
Neuropathology and Applied Neurobiology. 37:75-93
Cerebral amyloid angiopathy (CAA) may result from focal to widespread amyloid-β protein (Aβ) deposition within leptomeningeal and intracortical cerebral blood vessels. In addition, pericapillary Aβ refers to Aβ depositions in the glia limitans an
Autor:
Banerjee, Siddhartha1 (AUTHOR), Baghel, Divya1 (AUTHOR), Edmonds, Harrison O.1 (AUTHOR), Ghosh, Ayanjeet1 (AUTHOR) ayanjeet.ghosh@ua.edu
Publikováno v:
Small Science. Sep2024, Vol. 4 Issue 9, p1-12. 12p.
Autor:
A.M. Grande, Feng Xu, M. Vasek, John K. Robinson, Judianne Davis, Mary Lou Previti, W E Van Nostrand
Publikováno v:
Neuroscience. 146:98-107
Cerebral microvascular amyloid β protein (Aβ) deposition and associated neuroinflammation are increasingly recognized as an important component leading to cognitive impairment in Alzheimer’s disease and related cerebral amyloid angiopathy (CAA) d
Publikováno v:
Journal of Neurochemistry. 65:931-934
The progression of Alzheimer's disease and related disorders involves amyloid beta-protein (A beta) deposition and pathologic changes in the parenchyma as well as cerebral blood vessels. The cerebrovascular A beta deposits in these disorders are asso
Autor:
Niu Z; School of Pharmacy, Henan University, Kaifeng, Henan, 475004, China., Gui X; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Feng S; School of Pharmacy, Henan University, Kaifeng, Henan, 475004, China., Reif B; Bavarian NMR Center (B NMRZ), Department of Bioscience, TUM School of Natural Sciences, Technische Universität München (TUM), Garching, 85747, Germany.; Institute of Structural Biology (STB), Helmholtz-Zentrum, München (HMGU), Neuherberg, 85764, Germany.
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Aug 27; Vol. 30 (48), pp. e202400277. Date of Electronic Publication: 2024 Aug 02.
Autor:
M Porter, W E Van Nostrand
Publikováno v:
Biochemistry. 38:11570-11576
Cerebrovascular amyloid beta-protein (A beta) deposition, a key pathological feature of Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis Dutch-type, can lead to intracerebral hemorrhage; however, the mechanism for this remains
Publikováno v:
Journal of Biological Chemistry. 270:22827-22830
The Alzheimer's disease related protein, amyloid beta-protein precursor (A beta PP), contains a domain homologous to Kunitz-type serine protease inhibitors (KPI). The recombinant KPI domain of A beta PP is a potent inhibitor of coagulation factors XI
Publikováno v:
Virchows Archiv, 426(6), 603-610. Springer Verlag
In Alzheimer's disease (AD) patients, the complement components Clq, C4 and C3 can be detected in different types of beta/A4 plaques, one of the hallmarks of AD. Contradictory findings on the presence of late complement components in AD brains have b
Publikováno v:
Acta neuropathologica, 89(4), 356-362. Springer Verlag
In the present immunohistochemical study, we investigated the characteristics of altered neurites in the frontal cortex of 10 Alzheimer's disease (AD) brains and 15 age-matched non-demented control brains. In both AD and control cases, the altered ne