Zobrazeno 1 - 10
of 28
pro vyhledávání: '"W E Serafin"'
Autor:
E Tchekneva, W E Serafin
Publikováno v:
The Journal of Immunology. 152:5912-5921
Expansion of mast cell numbers occurs in vivo during certain inflammatory reactions, including active fibrosis, parasite infestations, and immediate hypersensitivity reactions. T cell-produced cytokines, including IL-3 and IL-4, are thought to contro
Publikováno v:
Proceedings of the National Academy of Sciences. 88:5984-5988
Sonicates of mouse bone marrow-derived mast cells (BMMC) differentiated in vitro and of mouse serosal mast cells differentiated in vivo contained small but approximately equal amounts of aminopeptidase activity, as determined by cleavage of leucine-b
Publikováno v:
Journal of Biological Chemistry. 266:3847-3853
The cDNA and gene for mouse mast cell protease-6 (MMCP-6) have been sequenced and show MMCP-6 to be translated as a prepro-enzyme with a 21-amino acid hydrophobic leader peptide, a 10-amino acid activation peptide, and a 245-amino acid mature enzyme.
Autor:
K F Austen, A Ebrahimi, P Marcham, T P Sullivan, D S Reynolds, W E Serafin, George A. Conder, S S Johnson
Publikováno v:
Journal of Biological Chemistry. 266:1934-1941
Based on the amino-terminal amino acid sequence of the mature form of mouse mast cell protease 4 (MMCP-4), previously identified in peritoneal connective tissue mast cells (CTMC) and Kirsten sarcoma virus-immortalized mast cells (KiSV-MC), a 26-mer o
Publikováno v:
Proceedings of the National Academy of Sciences. 87:3230-3234
Mouse serosal mast cells (SMCs) and Kirsten sarcoma virus-immortalized mast cells store large amounts of mast cell carboxypeptidase A and serine proteases in their secretory granules. Secretory granule proteins from 2.6 x 10(6) purified SMCs were sep
Autor:
George A. Conder, K F Austen, D S Reynolds, Richard L. Stevens, W E Serafin, Snezna Rogelj, S S Johnson, William S. Lane
Publikováno v:
Journal of Biological Chemistry. 265:423-429
A novel 28,000 Mr serine protease, designated mouse mast cell protease-2 (MMCP-2), that is stored in the secretory granules of Kirsten sarcoma virus-immortalized mouse mast cells (KiSV-MC) has been identified and its NH2-terminal amino acid sequence
Publikováno v:
The Journal of biological chemistry. 270(3)
Previously, we characterized murine mast cell procarboxypeptidase A (MC-proCPA) as an inactive zymogen. To investigate the mechanisms for this lack of enzymatic activity and the processing of the zymogen to the active form, we now have performed mole
Publikováno v:
The Journal of biological chemistry. 269(41)
By cDNA sequence analyses the proteases found within the secretory granules of immune/inflammatory cells appear to be translated initially as zymogens, but by amino-terminal sequencing they are stored within the granules in an active form. We now sho
Autor:
E, Tchekneva, W E, Serafin
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 152(12)
Expansion of mast cell numbers occurs in vivo during certain inflammatory reactions, including active fibrosis, parasite infestations, and immediate hypersensitivity reactions. T cell-produced cytokines, including IL-3 and IL-4, are thought to contro
Publikováno v:
The Journal of biological chemistry. 266(6)
The cDNA and gene for mouse mast cell protease-6 (MMCP-6) have been sequenced and show MMCP-6 to be translated as a prepro-enzyme with a 21-amino acid hydrophobic leader peptide, a 10-amino acid activation peptide, and a 245-amino acid mature enzyme.