Zobrazeno 1 - 10
of 37
pro vyhledávání: '"W E Mercer"'
Autor:
Kazuyasu Sakaguchi, M Fiscella, Shuren Shen, W E Mercer, H Zhang, S Fan, Patrick M. O'Connor, G F Vande Woude, Ettore Appella
Publikováno v:
Proceedings of the National Academy of Sciences. 94:6048-6053
Exposure of mammalian cells to ionizing radiation (IR) induces a complex array of cellular responses including cell cycle arrest and/or apoptosis. IR-induced G 1 arrest has been shown to depend on the presence of the tumor suppressor p53, which acts
Publikováno v:
Proceedings of the National Academy of Sciences. 89:9210-9214
Conditional expression of wild-type (wt) p53 protein in a glioblastoma tumor cell line has been shown to be growth inhibitory. We have now more precisely localized the position in the cell cycle where growth arrest occurs. We show that growth arrest
Publikováno v:
Journal of Biological Chemistry. 267:15259-15262
Autor:
Renato Baserga, W. E. Mercer, Bruno Calabretta, A Ferber, Salvatore Petralia, Salvatore Travali, Krzysztof Reiss
Publikováno v:
Molecular and Cellular Biology. 11:731-736
The proto-oncogene c-myb, whose expression is usually limited to cells of the hematopoietic lineages, can be expressed in fibroblasts if placed under the control of a constitutive promoter, such as the simian virus SV40 early promoter. 3T3 cells carr
Publikováno v:
The Journal of biological chemistry. 274(12)
The MDMX gene product is related to the MDM2 oncoprotein, both of which interact with the p53 tumor suppressor. We have identified a novel transcript of the MDMX gene that is expressed in a variety of cell lines, and in particular, in growing and tra
Autor:
W E, Mercer
Publikováno v:
Journal of cellular biochemistry. Supplement.
Cell cycle checkpoint controls play a major role in preventing the development of cancer [see Sherr, 1994, for a more detailed discussion]. Major checkpoints occur at the G1 to S phase transition and at the G2 to M phase transitions. Cancer is a gene
Publikováno v:
Human pathology. 28(10)
Genetic alterations in the p53 tumor suppressor gene are common in human colorectal cancers, occurring in approximately 70% of tumors. In vitro studies have shown that wild-type p53 is involved in controlling cell cycle checkpoint functions and apopt
Autor:
L, Grasso, W E, Mercer
Publikováno v:
Vitamins and hormones. 53
Publikováno v:
Cancer research. 55(13)
To better understand how the E2F1 transcription factor contributes to the process of cell proliferation, NIH-3T3 cell lines were generated that constitutively express either the wild-type E2F1 protein or an amino terminal deletion mutant, termed E2F1
Autor:
W, Zhang, L, Grasso, C D, McClain, A M, Gambel, Y, Cha, S, Travali, A B, Deisseroth, W E, Mercer
Publikováno v:
Cancer research. 55(3)
The p53 tumor suppressor gene plays a role in controlling a G1 phase checkpoint. The WAF1/CIP1 gene with encodes p21WAF1/CIP1 protein, an inhibitor of cyclin-dependent kinases, is a downstream mediator of p53 function. We examined expression of the W