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Correlation between 5-fluorouracil metabolism and treatment response in two variants of C26 murine colon carcinoma

Autor: Y J L Kamm, C.J.A. Punt, W E Hull, Arend Heerschap, G.J. Peters

Publikováno v: British journal of cancer, 89(4), 754-762. Nature Publishing Group
British Journal of Cancer, 89, 754-62
British Journal of Cancer, 89, 4, pp. 754-62
British Journal of Cancer

Item does not contain fulltext Following an i.p. dose of 150 mg x kg(-1) 5-fluorouracil (5-FU), drug uptake and metabolism over a 2-h period were studied by in vivo (19)F magnetic resonance spectroscopy (MRS) for the murine colon carcinoma lines C26-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672c1199cb9b7583dab1d5d69a0c39aa
https://doi.org/10.1038/sj.bjc.6601162

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Akademický článek

High-Efficiency Trifluoromethyl-Methionine Incorporation into Cyclophilin A by Cell-Free Synthesis for ¹⁹ F NMR Studies.

Autor: Zhu W; Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA-15261, United States., Monnie CM; Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA-15261, United States., Kitoka K; Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA-15261, United States.; Laboratory of Structural Biology and Drug Design, Latvian Institute of Organic Synthesis, Riga, LV1006, Latvia., Gronenborn AM; Department of Structural Biology, University of Pittsburgh School of Medicine, 3501 Fifth Ave., Pittsburgh, PA-15261, United States.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Nov 21, pp. e202419709. Date of Electronic Publication: 2024 Nov 21.

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Akademický článek

From Mysore to Cambridge and back: The education of a groundnut breeder.

Autor: Brown, Tad¹ tadbrown23.5@gmail.com

Publikováno v: Plants, People, Planet. Sep2024, Vol. 6 Issue 5, p1014-1023. 10p.

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Akademický článek

Hydroxytyrosol-1-Glucopyranoside Alleviates Senescence via Nrf2 and AMPK Signaling Pathway.

Autor: Yang Guo¹, Bo Zhang¹, Yongzhi Han¹, Iqbal, Muhammad Waleed¹, Jia Wang¹, Xiaolin Shen¹, Hao Liang¹, Xinxiao Sun¹ sunxx@mail.buct.edu.cn, Qipeng Yuan¹ yuanqp@mail.buct.edu.cn

Publikováno v: Records of Natural Products. Jul/Aug2024, Vol. 18 Issue 4, p405-418. 14p.

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Inhibition of protein N-glycosylation by 2-deoxy-2-fluoro-d-galactose

Autor: Wolfgang Gerok, U Berger, W E Hull, Tilo Andus, W Kreisel, Dietrich Keppler, Volker Gross

Publikováno v: Biochemical Journal. 285:821-826

The effects of 2-deoxy-2-fluoro-D-galactose (dGalF) on N- and O-glycosylation of proteins was studied in rat hepatocyte primary cultures and in human monocytes. In hepatocytes, dGalF at concentrations of 1 mM or higher completely inhibited N-glycosyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f40536669dfaf9cad1890761d2927d1
https://doi.org/10.1042/bj2850821

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Akademický článek

Fluorinated Tags to Study Protein Conformation and Interactions Using ¹⁹ F NMR.

Autor: Hanson GSM; EaStChem School of Chemistry, University of Edinburgh, Joseph Black Building, Kings Buildings, West Mains Road, EH9 3FJ, Edinburgh, UK., Coxon CR; EaStChem School of Chemistry, University of Edinburgh, Joseph Black Building, Kings Buildings, West Mains Road, EH9 3FJ, Edinburgh, UK.

Publikováno v: Chembiochem : a European journal of chemical biology [Chembiochem] 2024 Aug 01; Vol. 25 (15), pp. e202400195. Date of Electronic Publication: 2024 Jun 24.

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Cytosine deaminase and thymidine kinase gene therapy in a Dunning rat prostate tumour model: absence of bystander effects and characterisation of 5-fluorocytosine metabolism with 19F-NMR spectroscopy

Autor: Heike Corban-Wilhelm, Jürgen Debus, W E Hull, G Becker, D Greulich, U Bauder-Wüst

Publikováno v: Gene therapy. 9(23)

The rat prostate tumour cell line R3327 AT-1 was transfected with a gene coding for a fusion protein comprised of cytosine deaminase (CD from E. coli) and thymidine kinase (TK from Herpes simplex virus, HSV-1). The resulting AT-1/CDglyTK cell line wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812e0f53047bb140fd319e2da4ee68d4
https://pubmed.ncbi.nlm.nih.gov/12424609

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Identification of lignans as major components in the phenolic fraction of olive oil

Autor: R W, Owen, W, Mier, A, Giacosa, W E, Hull, B, Spiegelhalder, H, Bartsch

Publikováno v: Clinical chemistry. 46(7)

Because olive oil is an important component of the Mediterranean diet, it is necessary to establish unequivocal identification of the major potential antioxidant phenolic compounds it contains.The major phenolic antioxidants in extra virgin olive oil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a19b00049ae494857341bbab54b2cc1b
https://pubmed.ncbi.nlm.nih.gov/10894841

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