Zobrazeno 1 - 10
of 45
pro vyhledávání: '"W E Fogler"'
Autor:
Shaji Kumar, Elena Ellert, M. Andrulis, C. Connolly, W. E. Fogler, Lucy Kirkham-McCarthy, S. C. Locatelli-Hoops, Alessandro Natoni, Cian McEllistrim, I. Oliva, Niamh Keane, T. A.G. Smith, Michael O'Dwyer, Marc-Steffen Raab, Alokkumar Jha, Siobhan Glavey, John L. Magnani
Publikováno v:
Leukemia
Multiple myeloma (MM) is characterized by the clonal expansion and metastatic spread of malignant plasma cells to multiple sites in the bone marrow (BM). Recently, we implicated the sialyltransferase ST3Gal-6, an enzyme critical to the generation of
Publikováno v:
The Journal of Immunology. 159:4187-4196
Killer cell inhibitory receptors represent a family of p58/70-Ig-like proteins expressed on the surface of human NK cells. Engagement of class I MHC by killer cell inhibitory receptors turns off the lytic machinery of NK cells. This receptor/ligand i
Publikováno v:
The Journal of Immunology. 156:4707-4714
The mechanisms that regulate the adhesion and migration of NK cells to and across endothelium have been studied under nonflow conditions; however, the involvement of these processes in vivo is poorly understood. The present studies investigated the p
Publikováno v:
The Journal of Immunology. 153:333-342
Isolated murine splenic NK cells and the cultured murine endothelioma cell line, eEND2, were used to study the effects of cytokines on NK cell/endothelial cell adhesion. Treatment of eEND2 cells with TNF-alpha induced a marked increase (four- to seve
Autor:
B K, Sim, W E, Fogler, X H, Zhou, H, Liang, J W, Madsen, K, Luu, M S, O'Reilly, J E, Tomaszewski, A H, Fortier
Publikováno v:
Angiogenesis. 3(1)
Endostatin, a potent endogenous inhibitor of angiogenesis, inhibits the growth of primary tumors without induction of acquired drug resistance in mice. We report that a soluble recombinant human (rh) Endostatin produced with characteristics of the na
Autor:
O, Kisker, C M, Becker, D, Prox, M, Fannon, R, D'Amato, E, Flynn, W E, Fogler, B K, Sim, E N, Allred, S R, Pirie-Shepherd, J, Folkman
Publikováno v:
Cancer research. 61(20)
In the first Phase I clinical trials of endostatin as an antiangiogenic therapy for cancer, the protein was administered as an i.v. bolus for approximately 20-30 min each day. This protocol was based on experimental studies in which animals were trea
Autor:
M, Watanabe, R G, Fenton, J M, Wigginton, K L, McCormick, K M, Volker, W E, Fogler, P G, Roessler, R H, Wiltrout
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 163(4)
In this study four murine IL-12 naked DNA expression plasmids (pIL-12), containing both the p35 and p40 subunits, were shown to induce systemic biological effects in vivo after intradermal injection. Three of the four IL-12 expression vectors augment
Autor:
W E, Fogler, K, Volker, M, Watanabe, J M, Wigginton, P, Roessler, M J, Brunda, J R, Ortaldo, R H, Wiltrout
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 161(11)
NK cells have been shown to be important antitumor or antiviral effector cells in the liver. In the present study we have examined the factors that regulate the initial recruitment and subsequent fate of hepatic NK and T cells in mice treated with IL
Autor:
M, Watanabe, K L, McCormick, K, Volker, J R, Ortaldo, J M, Wigginton, M J, Brunda, R H, Wiltrout, W E, Fogler
Publikováno v:
The American journal of pathology. 150(5)
The regulation of tumor growth by cytokine-induced alterations in host effector cell recruitment and activation is intimately associated with leukocyte adhesion and angiogenic modulation. In the present study, we have developed a novel tumor model to
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 156(12)
The mechanisms that regulate the adhesion and migration of NK cells to and across endothelium have been studied under nonflow conditions; however, the involvement of these processes in vivo is poorly understood. The present studies investigated the p