Výsledky vyhledávání - "W E, Gillanders"

Sustained release of granulocyte-macrophage colony-stimulating factor from a modular peptide-based cancer vaccine alters vaccine microenvironment and enhances the antigen-specific T-cell response

Autor: C L, Nguyen, J T, Bui, M, Demcheva, J N, Vournakis, D J, Cole, W E, Gillanders

Publikováno v: Journal of immunotherapy (Hagerstown, Md. : 1997). 24(5)

The recent identification and molecular characterization of tumor antigens provides the opportunity to explore the rational development of peptide-based cancer vaccines. However, the response to these vaccines remains variable, and peptide-based canc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0a1678a332fb7857be6c4ae8862a917e
https://pubmed.ncbi.nlm.nih.gov/11696697

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Alloreactive and syngeneic CTL are comparably dependent on interaction with MHC class I alpha-helical residues

Autor: T M, Hornell, J C, Solheim, N B, Myers, W E, Gillanders, G K, Balendiran, T H, Hansen, J M, Connolly

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 163(6)

The molecular basis for the difference in the strength of T cell responses to self vs alloantigens is unknown, but may reflect how T cells are selected in the thymus. Because T cells with a high affinity for foreign as opposed to self MHC molecules a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::65e783d14cf440841ed6b154b841f226
https://pubmed.ncbi.nlm.nih.gov/10477590

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Evidence for clonal deletion and clonal anergy after intrathymic antigen injection in a transplantation model

Autor: W E, Gillanders, T, Arima, F, Tu, T H, Hansen, M W, Flye

Publikováno v: Transplantation. 64(8)

Intrathymic (IT) antigen injection has been shown to induce antigen-specific systemic tolerance in the rodent. To delineate the mechanisms responsible for the induction of tolerance, we used the 2C line of T cell receptor transgenic mice. The majorit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::838cf7b345bfe983d685faa224c4fcd0
https://pubmed.ncbi.nlm.nih.gov/9355834

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Biochemical and functional characterization of soluble multivalent MHC L(d)/Fc gamma 1 and L(d)/Fc mu chimeric proteins loaded with specific peptides

Autor: D M, Lepley, W E, Gillanders, N B, Myers, R A, Robinson, K W, Beisel, J L, Wisecarver, S J, Pirruccello, D R, Lee, T H, Hansen, R J, Rubocki

Publikováno v: Transplantation. 63(5)

Central to the specificity of the immune system is the interaction between the T cell receptor and the major histocompatibility complex (MHC)-peptide ligand complex. To better understand the nature of this interaction, and to investigate possible ave

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a41e098c078a57fd664e8fe6cbaea9dd
https://pubmed.ncbi.nlm.nih.gov/9075851

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Generation of human IgG, IgA, and IgM anti-melanoma monoclonal antibodies utilizing lymphocytes of an actively immunized melanoma patient

Autor: Z A, Abdel-wahab, W E, Gillanders, T L, Darrow, H F, Seigler

Publikováno v: Human antibodies and hybridomas. 3(1)

Active specific immunotherapy with irradiated allogeneic melanoma cells has been shown to enhance the humoral immune response in melanoma patients. An increased titer of melanoma-binding antibodies was demonstrated in sera of immunized patients. Lymp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef402c0d924b2b9f980e0e0b13737cbb
https://pubmed.ncbi.nlm.nih.gov/1576321

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