Zobrazeno 1 - 10 of 11 pro vyhledávání: '"W E, Cascio"'
1
Early changes in extracellular potassium in ischemic rabbit myocardium. The role of extracellular carbon dioxide accumulation and diffusion
Autor: W. E. Cascio, André G. Kléber, Gan-Xin Yan
Publikováno v: Circulation Research. 70:409-422
The role of local accumulation and diffusion of CO2 to modify cellular loss and extracellular accumulation of K+ during the initial, reversible phase of myocardial ischemia was investigated in isolated, cylindrical papillary muscles of the rabbit. Th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b12330edba6eede18d272582a3758fce
https://doi.org/10.1161/01.res.70.2.409
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2
A LabVIEW model incorporating an open-loop arterial impedance and a closed-loop circulatory system
Autor: Carol L. Lucas, Timothy A. Johnson, R. T. Cole, W. E. Cascio
Publikováno v: Annals of biomedical engineering. 33(11)
While numerous computer models exist for the circulatory system, many are limited in scope, contain unwanted features or incorporate complex components specific to unique experimental situations. Our purpose was to develop a basic, yet multifaceted,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7722ba4a750a7ce1ece2c0a37119040
https://pubmed.ncbi.nlm.nih.gov/16341923
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4
Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death
Autor: J J, Lemasters, T, Qian, C A, Bradham, D A, Brenner, W E, Cascio, L C, Trost, Y, Nishimura, A L, Nieminen, B, Herman
Publikováno v: Journal of bioenergetics and biomembranes. 31(4)
Mitochondria are frequently the target of injury after stresses leading to necrotic and apoptotic cell death. Inhibition of oxidative phosphorylation progresses to uncoupling when opening of a high conductance permeability transition (PT) pore in the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::649ae6a2bdb8237f82c367926af54c9e
https://pubmed.ncbi.nlm.nih.gov/10665521
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5
Correlation of ischemia-induced extracellular and intracellular ion changes to cell-to-cell electrical uncoupling in isolated blood-perfused rabbit hearts. Experimental Working Group
Autor: L M, Owens, T A, Fralix, E, Murphy, W E, Cascio, L S, Gettes
Publikováno v: Circulation. 94(1)
The relationships between the metabolic, ionic, and electrical changes of acute ischemia have not been determined precisely because they have been studied under different experimental conditions. We used ion-selective electrodes, nuclear magnetic res
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9fa9893e1f941a68d602cce05b641965
https://pubmed.ncbi.nlm.nih.gov/8964108
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6
The pH paradox in ischemia-reperfusion injury to cardiac myocytes
Autor: J J, Lemasters, J M, Bond, E, Chacon, I S, Harper, S H, Kaplan, H, Ohata, D R, Trollinger, B, Herman, W E, Cascio
Publikováno v: EXS. 76
During myocardial ischemia, a large reduction of tissue pH develops, and tissue pH returns to normal after reperfusion. In recent studies, we evaluated the role of pH in ischemia/reperfusion injury to cultured cardiac myocytes and perfused papillary
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8dd9976d2393da7ef9b1ee36bc4ac0b1
https://pubmed.ncbi.nlm.nih.gov/8805791
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7
The Ib phase of ventricular arrhythmias in ischemic in situ porcine heart is related to changes in cell-to-cell electrical coupling. Experimental Cardiology Group, University of North Carolina
Autor: W T, Smith, W F, Fleet, T A, Johnson, C L, Engle, W E, Cascio
Publikováno v: Circulation. 92(10)
This study was designed to test the hypothesis that the loss of cell-to-cell electrical interaction during ischemia modulates the amplitude of ischemia-induced TQ-segment depression (ie, the injury potential) and the occurrence of ventricular fibrill
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::367550a5f828861598656e6efc27e4e1
https://pubmed.ncbi.nlm.nih.gov/7586276
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8
Hypercapnic acidosis and dimethyl amiloride reduce reperfusion induced cell death in ischaemic ventricular myocardium
Autor: S H, Kaplan, H, Yang, D E, Gilliam, J, Shen, J J, Lemasters, W E, Cascio
Publikováno v: Cardiovascular research. 29(2)
The aim was to investigate the effects of slowing the recovery of ischaemia induced intracellular acidosis with hypercapnic acidosis or dimethyl amiloride (DMA) on the extent of reperfusion induced cell death.Isolated arterially perfused rabbit papil
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1a4f02c47c557c6e03f62a8945c91ed2
https://pubmed.ncbi.nlm.nih.gov/7736500
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9
Passive electrical properties, mechanical activity, and extracellular potassium in arterially perfused and ischemic rabbit ventricular muscle. Effects of calcium entry blockade or hypocalcemia
Autor: W. E. Cascio, Gan-Xin Yan, André G. Kléber
Publikováno v: Circulation research. 66(6)
The relation among passive electrical resistive properties, longitudinal conduction velocity, extracellular potassium concentration, [K+]o, and mechanical activity was investigated in the isolated rabbit papillary muscle during normal arterial perfus
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d95aea976e1a765f0fa3e8ff4a8ef3
https://pubmed.ncbi.nlm.nih.gov/2344662
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