Zobrazeno 1 - 10
of 35
pro vyhledávání: '"W Douglas Figg"'
Autor:
Katie E. Hebron, Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, William J.E. Frye, Angela Kim, Stacey Stauffer, Olivia L. Perkins, Wenyue Sun, Kristine A. Isanogle, Christina M. Robinson, Amy James, Parirokh Awasthi, Priya Shankarappa, Xiaoling Luo, Haiyan Lei, Donna Butcher, Roberta Smith, Elijah F. Edmondson, Jin-Qiu Chen, Noemi Kedei, Cody J. Peer, Jack F. Shern, W. Douglas Figg, Lu Chen, Matthew D. Hall, Simone Difilippantonio, Frederic G. Barr, Robert L. Kortum, Robert W. Robey, Angelina V. Vaseva, Javed Khan, Marielle E. Yohe
Publikováno v:
Clinical Cancer Research. 29:472-487
Purpose: PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition. Overexpression of IGF1R and its ligands is also observed in FN RMS. Preclinical and clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047b86373dabd6b6d63e13259e932a36
https://doi.org/10.1158/1078-0432.ccr-22-1646
https://doi.org/10.1158/1078-0432.ccr-22-1646
Autor:
Marielle E. Yohe, Javed Khan, Angelina V. Vaseva, Robert W. Robey, Robert L. Kortum, Frederic G. Barr, Simone Difilippantonio, Matthew D. Hall, Lu Chen, W. Douglas Figg, Jack F. Shern, Cody J. Peer, Noemi Kedei, Jin-Qiu Chen, Elijah F. Edmondson, Roberta Smith, Donna Butcher, Haiyan Lei, Xiaoling Luo, Priya Shankarappa, Parirokh Awasthi, Amy James, Christina M. Robinson, Kristine A. Isanogle, Wenyue Sun, Olivia L. Perkins, Stacey Stauffer, Angela Kim, William J.E. Frye, Nancy E. Sealover, David J. Liewehr, Jacob S. Roth, Xiaolin Wan, Katie E. Hebron
Pharmacodynamic response to trametinib/ganitumab in xenograft models does not predict tumor shrinkage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d7c566bea37a5d8427b5ace824dcd1e
https://doi.org/10.1158/1078-0432.22488359
https://doi.org/10.1158/1078-0432.22488359
Autor:
Marielle E. Yohe, Javed Khan, Angelina V. Vaseva, Robert W. Robey, Robert L. Kortum, Frederic G. Barr, Simone Difilippantonio, Matthew D. Hall, Lu Chen, W. Douglas Figg, Jack F. Shern, Cody J. Peer, Noemi Kedei, Jin-Qiu Chen, Elijah F. Edmondson, Roberta Smith, Donna Butcher, Haiyan Lei, Xiaoling Luo, Priya Shankarappa, Parirokh Awasthi, Amy James, Christina M. Robinson, Kristine A. Isanogle, Wenyue Sun, Olivia L. Perkins, Stacey Stauffer, Angela Kim, William J.E. Frye, Nancy E. Sealover, David J. Liewehr, Jacob S. Roth, Xiaolin Wan, Katie E. Hebron
Related to Figure 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddd7fae2aafc437f40291da739fe21d2
https://doi.org/10.1158/1078-0432.22488377.v1
https://doi.org/10.1158/1078-0432.22488377.v1
Autor:
Marielle E. Yohe, Javed Khan, Angelina V. Vaseva, Robert W. Robey, Robert L. Kortum, Frederic G. Barr, Simone Difilippantonio, Matthew D. Hall, Lu Chen, W. Douglas Figg, Jack F. Shern, Cody J. Peer, Noemi Kedei, Jin-Qiu Chen, Elijah F. Edmondson, Roberta Smith, Donna Butcher, Haiyan Lei, Xiaoling Luo, Priya Shankarappa, Parirokh Awasthi, Amy James, Christina M. Robinson, Kristine A. Isanogle, Wenyue Sun, Olivia L. Perkins, Stacey Stauffer, Angela Kim, William J.E. Frye, Nancy E. Sealover, David J. Liewehr, Jacob S. Roth, Xiaolin Wan, Katie E. Hebron
Purpose:PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition. Overexpression of IGF1R and its ligands is also observed in FN RMS. Preclinical and clinical s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92f2495e02f2004856ed709224efafc9
https://doi.org/10.1158/1078-0432.c.6532697.v1
https://doi.org/10.1158/1078-0432.c.6532697.v1
Autor:
Sarath P. D. Seenadera, Sarah A. Long, Rhone Akee, Gabriela Bermudez, Gregory Parsonage, Jonathan Strope, Cody Peer, W. Douglas Figg, Kathlyn A. Parker, David J. Beech, John A. Beutler
Publikováno v:
ACS medicinal chemistry letters. 13(9)
Modifications at the glycolate moiety of englerin A were made to explore variations at the most sensitive site on the molecule for activity in the NCI 60 screen, wherein englerin A is highly potent and selective for renal cancer cells. Replacement of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1b9a0a96ab591257560615229ae9a1
https://pubmed.ncbi.nlm.nih.gov/36105325
https://pubmed.ncbi.nlm.nih.gov/36105325
Autor:
Marielle E. Yohe, Katie E. Hebron, Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, Stacey Stauffer, Olivia Feehan-Nelson, Wenyue Sun, Kristine A. Isanogle, Christina M. Robinson, Amy James, Parirokh Awasthi, Priya Shankarappa, Xiaoling Liu, Haiyan Lei, Donna Butcher, Roberta Smith, Elijah F. Edmonson, Jin-Qui Chen, Noemi Kedei, Cody S. Peer, Jack F. Shern, W. Douglas Figg, Lu Chen, Matthew D. Hall, Simone Difillipantonio, Frederic G. Barr, Robert L. Kortum, Angelina V. Vaseva, Javed Khan
Publikováno v:
Clinical Cancer Research. 28:IA023-IA023
Background: PAX-fusion negative rhabdomyosarcoma (FN RMS) is driven by alterations in the RAS/MAP kinase pathway and is partially responsive to MEK inhibition. Overexpression of IGF1R and its ligands is also observed in FN RMS. Preclinical and clinic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7890151a1334855c892ebb63b178b742
https://doi.org/10.1158/1557-3265.sarcomas22-ia023
https://doi.org/10.1158/1557-3265.sarcomas22-ia023
Autor:
Josh Kramer, Cynthia McCully, Matthew Breed, W. Douglas Figg, Sylwia A. Stopka, Sara Zimmerman, Katherine E. Warren, Cody J. Peer, Thet Aye, Rafael Cruz Garcia, Nathalie Y. R. Agar, Michael S. Regan
Publikováno v:
Neuro-Oncology
Adequate exposure (effective concentration over time) of a therapeutic agent at its site of action is essential for antitumor efficacy. Given constraints of repeat tissue sampling, non-human primate models predictive of pharmacokinetics in pediatric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81ec0926a950b4433acbb2ff1c6e9714
http://europepmc.org/articles/PMC8168181
http://europepmc.org/articles/PMC8168181
Autor:
Amar Gajjar, W. Douglas Figg, Cody J. Peer, Allen Buxton, Katherine E. Warren, Gilbert Vezina, Maryam Fouladi, Linda Springer, Daniel C. Bowers, Mark Krailo
Publikováno v:
Neuro-Oncology
Children with low-grade glioma have excellent survival rates but often suffer from the morbidity of treatment, particularly from cytotoxic chemotherapies. Targeted agents appear to have some activity but the long-term effects of inhibiting normal dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0d14e531b4cac0616a8c10f5a85f49
https://doi.org/10.1093/neuonc/noab090.202
https://doi.org/10.1093/neuonc/noab090.202
Autor:
W. Douglas Figg, John A. Beutler, Leonard M. Neckers, William J. Chain, David M. Fash, Carole Sourbier, Ian J. Talisman, Joe W. Ramos, Zhenwu Li, Florian J. Sulzmaier, Sima Hayavi, Cody J. Peer
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2641-2644
Synthesis of analogues of englerin A with a reduced propensity for hydrolysis of the glycolate moiety led to a compound which possessed the renal cancer cell selectivity of the parent and was orally bioavailable in mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916a52624a7233c640385f1e8d82c2d2
https://doi.org/10.1016/j.bmcl.2016.04.016
https://doi.org/10.1016/j.bmcl.2016.04.016
Autor:
Anne M. Noonan, Christina M. Annunziata, Elise C. Kohn, Robert J. Kinders, Elizabeth Jordan, Nicole D. Houston, Michelle A. Herrmann, Kristen P. Bunch, Jin-Qiu Chen, Cody J. Peer, Ciara C. O’Sullivan, Liang Cao, Naoko Takebe, Jung-Min Lee, W. Douglas Figg
Publikováno v:
Cancer. 122:588-597
BACKGROUND Inhibitors of apoptosis proteins (IAPs) are key regulators of apoptosis and are frequently dysregulated in ovarian cancer. It was hypothesized that blocking IAPs with birinapant would increase tumor cell death and result in objective respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::79b44cce349da59b442627b73c0860e3
https://doi.org/10.1002/cncr.29783
https://doi.org/10.1002/cncr.29783