Zobrazeno 1 - 10
of 24
pro vyhledávání: '"W David Holtzclaw"'
Autor:
Jay H Kalin, Abdulkerim Eroglu, Hua Liu, W David Holtzclaw, Irene Leigh, Charlotte M Proby, Jed W Fahey, Philip A Cole, Albena T Dinkova-Kostova
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0213095 (2019)
Cutaneous squamous cell carcinomas are a common form of highly mutated keratinocyte skin cancers that are of particular concern in immunocompromised patients. Here we report on the efficacy of topically applied MS-275, a clinically used histone deace
Externí odkaz:
https://doaj.org/article/f99b3105935445b2977644ef674fd19e
Autor:
Jed W Fahey, W David Holtzclaw, Scott L Wehage, Kristina L Wade, Katherine K Stephenson, Paul Talalay
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0140963 (2015)
Glucoraphanin from broccoli and its sprouts and seeds is a water soluble and relatively inert precursor of sulforaphane, the reactive isothiocyanate that potently inhibits neoplastic cellular processes and prevents a number of disease states. Sulfora
Externí odkaz:
https://doaj.org/article/78a97218011144d88d500270d5e4bb33
Autor:
W. David Holtzclaw, Jay H. Kalin, Abdulkerim Eroglu, Albena T. Dinkova-Kostova, Hua Liu, Charlotte M. Proby, Irene M. Leigh, Jed W. Fahey, Philip A. Cole
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 3, p e0213095 (2019)
PLoS ONE, Vol 14, Iss 3, p e0213095 (2019)
Cutaneous squamous cell carcinomas are a common form of highly mutated keratinocyte skin cancers that are of particular concern in immunocompromised patients. Here we report on the efficacy of topically applied MS-275, a clinically used histone deace
Publikováno v:
Phytochemical Analysis. 26:47-53
Introduction Myrosinase (thioglucoside glucohydrolase; E.C. 3.2.1.147), is a plant enzyme of increasing interest and importance to the biomedical community. Myrosinase catalyses the formation of isothiocyanates such as sulforaphane (from broccoli) an
Autor:
Jed W. Fahey, Albena T. Dinkova-Kostova, Katherine K. Stephenson, Paul Talalay, W. David Holtzclaw, Kristina L. Wade, Lingxiang Ye, Theresa A. Shapiro
Publikováno v:
Nutrition and Cancer. 55:53-62
Broccoli sprouts are widely consumed in many parts of the world. There have been no reported concerns with respect to their tolerance and safety in humans. A formal phase I study of safety, tolerance, and pharmacokinetics appeared justified because t
Publikováno v:
Biochemistry. 44:6889-6899
Induction of the phase 2 response, a major cellular reaction to oxidative/electrophile stress depends on a protein triad: actin-tethered Keap1 that binds to Nrf2. Inducers react with Keap1 releasing Nrf2 for nuclear translocation and activation of th
Autor:
Nobunao Wakabayashi, Thomas W. Kensler, W. David Holtzclaw, Akira Kobayashi, Moon Il Kang, Paul Talalay, Albena T. Dinkova-Kostova, Masayuki Yamamoto
Publikováno v:
Proceedings of the National Academy of Sciences. 101:2040-2045
Induction of a family of phase 2 genes encoding for proteins that protect against the damage of electrophiles and reactive oxygen intermediates is potentially a major strategy for reducing the risk of cancer and chronic degenerative diseases. Many ph
Publikováno v:
Phytochemical analysis : PCA. 26(1)
Myrosinase (thioglucoside glucohydrolase; E.C. 3.2.1.147), is a plant enzyme of increasing interest and importance to the biomedical community. Myrosinase catalyses the formation of isothiocyanates such as sulforaphane (from broccoli) and 4-(α-l-rha
Publikováno v:
Biochemical Journal. 341:725-732
Myrosinase (thioglucoside glucohydrolase; EC 3.2.3.1) is a plant enzyme that hydrolyses glucosinolates, principally to isothiocyanates. Myrosinase was purified to homogeneity in good yield from 8-day-old seedlings of Raphanus sativus (daikon) using a
Autor:
Chitrananda Abeygunawardana, Tory Prestera, Joseph L. Kachinski, W. David Holtzclaw, Paul Talalay, Jed W. Fahey
Publikováno v:
Analytical Biochemistry. 239:168-179
Much effort has been devoted to developing methods for the efficient isolation and identification of glucosinolates. Existing methods for separation involve ion exchange, GLC, and HPLC (mostly after chemical modification by enzymatic sulfate removal