Zobrazeno 1 - 10
of 33
pro vyhledávání: '"W David, Hong"'
Autor:
Rachel H. Clare, Catherine Bardelle, Paul Harper, W. David Hong, Ulf Börjesson, Kelly L. Johnston, Matthew Collier, Laura Myhill, Andrew Cassidy, Darren Plant, Helen Plant, Roger Clark, Darren A. N. Cook, Andrew Steven, John Archer, Paul McGillan, Sitthivut Charoensutthivarakul, Jaclyn Bibby, Raman Sharma, Gemma L. Nixon, Barton E. Slatko, Lindsey Cantin, Bo Wu, Joseph Turner, Louise Ford, Kirsty Rich, Mark Wigglesworth, Neil G. Berry, Paul M. O’Neill, Mark J. Taylor, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Parasitic nematodes causing onchocerciasis and lymphatic filariasis rely on a bacterial endosymbiont, Wolbachia, which is a validated therapeutic target. Here, Clare et al. perform a high-throughput screen of 1.3 million compounds and identify 5 chem
Externí odkaz:
https://doaj.org/article/4cb4bba947a8460babf1f27b9cb22a73
Autor:
Kangsa Amporndanai, Nattapon Pinthong, Paul M. O’Neill, W. David Hong, Richard K. Amewu, Chandrakala Pidathala, Neil G. Berry, Suet C. Leung, Stephen A. Ward, Giancarlo A. Biagini, S. Samar Hasnain, Svetlana V. Antonyuk
Publikováno v:
Biology, Vol 11, Iss 8, p 1109 (2022)
Antimalarials targeting the ubiquinol-oxidation (Qo) site of the Plasmodium falciparum bc1 complex, such as atovaquone, have become less effective due to the rapid emergence of resistance linked to point mutations in the Qo site. Recent findings show
Externí odkaz:
https://doaj.org/article/b74084f8e68b4a56bee023bd1e647e27
Autor:
W. David Hong, Paul M. O’Neill, Mark J. Taylor, Joseph D. Turner, Stephen A. Ward, Fabian Gusovsky, Farid Benayoud, Nao Shibuguchi, Dixit Girish, Francis Gerard Fang, Ravi Kumar Talabhakthla, Anand Vaddi, Chiranjeevi Challa, Karri Satya Ammi Reddy, Vijay Kalla, Sugandham Srinivasa Rao, Durga Mahesh Kumar Nagireddi, Jayesh Patel, Anil Shahaji Khile
Publikováno v:
Organic Process Research & Development. 27:42-53
Autor:
Laura N. Jeffreys, Alison Ardrey, Taghreed A. Hafiz, Lauri-Anne Dyer, Ashley J. Warman, Nada Mosallam, Gemma L. Nixon, Nicholas E. Fisher, W. David Hong, Suet C. Leung, Ghaith Aljayyoussi, Jaclyn Bibby, Deepak V. Almeida, Paul J. Converse, Nader Fotouhi, Neil G. Berry, Eric L. Nuermberger, Anna M. Upton, Paul M. O’Neill, Stephen A. Ward, Giancarlo A. Biagini
Publikováno v:
ACS Infectious Diseases. 9:221-238
Autor:
Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M. Shackleford, Simon Campbell, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Michael J. Palmer, Ian M. Copple, Amy E. Mercer, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H. M. Kocken, Anne-Marie Zeeman, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is eff
Externí odkaz:
https://doaj.org/article/d0b09995908d4fd1a466aa398f702f2f
Autor:
W. David Hong, Stephen A. Ward, Paul M. O'Neill, Kelly L. Johnston, Mark J. Taylor, Joseph D. Turner
Publikováno v:
TRENDS IN PARASITOLOGY
The mutualistic association between Wolbachia endosymbionts and their filarial nematode hosts has been exploited as a validated drug target delivering macrofilaricidal outcomes. Limitations of existing antibiotics to scale-up have driven the search f
Autor:
Peter J. H. Webborn, Stefan Kavanagh, Andrew Cassidy, Paul M. O'Neill, Rachel H. Clare, Mark J. Taylor, Mark C. Wenlock, Neil G. Berry, W. David Hong, Darren A. N. Cook, Gemma L. Nixon, Stephen A. Ward, Paul McGillan, Suet C. Leung, Kelly L. Johnston, Louise Ford
Publikováno v:
ACS Medicinal Chemistry Letters
Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR
Autor:
Paul, McGillan, Neil G, Berry, Gemma L, Nixon, Suet C, Leung, Peter J H, Webborn, Mark C, Wenlock, Stefan, Kavanagh, Andrew, Cassidy, Rachel H, Clare, Darren A, Cook, Kelly L, Johnston, Louise, Ford, Stephen A, Ward, Mark J, Taylor, W David, Hong, Paul M, O'Neill
Publikováno v:
ACS Medicinal Chemistry Letters
Anti-Wolbachia therapy has been identified as a viable treatment for combating filarial diseases. Phenotypic screening revealed a series of pyrazolopyrimidine hits with potent anti-Wolbachia activity. This paper focuses on the exploration of the SAR
Autor:
Ding Shen, Kun Zhang, Zhengyun Jiang, Suqing Zhao, W. David Hong, Stephen A. Ward, Paul M. O'Neill, Mark J. Taylor, Xiping Cui, Panpan Wu, Gao Hongcan, Yingshan Chen, Zhang Bingjie, Yang Yang
Publikováno v:
RSC Advances. 7:52227-52237
A series of N4-benzylamine-N2-isopropyl-quinazoline-2,4-diamine derivatives has been synthesized and tested for antibacterial activity against five bacterial strains. Twelve different substituents on the N4-benzylamine group have been investigated al
Autor:
Richard S. Priestley, Giancarlo A. Biagini, Paul M. O'Neill, Kangsa Amporndanai, Jill Davies, W. David Hong, Gemma L. Nixon, Svetlana V. Antonyuk, Stephen A. Ward, Suet C. Leung, S. Samar Hasnain, Neil G. Berry
Publikováno v:
ACS Medicinal Chemistry Letters
[Image: see text] A series of 2-pyrazolyl quinolones has been designed and synthesized in 5–7 steps to optimize for both in vitro antimalarial potency and various in vitro drug metabolism and pharmacokinetics (DMPK) features. The most potent compou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1e1ed03122835c304452b49c545bff
https://doi.org/10.1021/acsmedchemlett.8b00371
https://doi.org/10.1021/acsmedchemlett.8b00371