Zobrazeno 1 - 10
of 144
pro vyhledávání: '"W David, Arnold"'
Autor:
Christopher J. Gilbert, Charles P. Rabolli, Volha A. Golubeva, Kristina M. Sattler, Meifang Wang, Arsh Ketabforoush, W. David Arnold, Christoph Lepper, Federica Accornero
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The regulation of proteostasis is fundamental for maintenance of muscle mass and function. Activation of the TGF-β pathway drives wasting and premature aging by favoring the proteasomal degradation of structural muscle proteins. Yet, how th
Externí odkaz:
https://doaj.org/article/76a086d225274d19b9e5e63a238d8b1e
Publikováno v:
The Journal of Nutrition, Health and Aging, Vol 28, Iss 6, Pp 100219- (2024)
Objective: Pathological, age-related loss of muscle function, commonly referred to as sarcopenia, contributes to loss of mobility, impaired independence, as well as increased risk of adverse health events. Sarcopenia has been attributed to changes in
Externí odkaz:
https://doaj.org/article/ff498c5d6ea5468a86d207bdb58ae28e
Autor:
Gregory Owendoff, Alissa Ray, Prameela Bobbili, Leatha Clark, Cory W. Baumann, Brian C. Clark, W. David Arnold
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 5, Pp 2439-2445 (2023)
Externí odkaz:
https://doaj.org/article/16b70d6a689945179a4bd390b15e225f
Autor:
Camila F. Almeida, Florence Robriquet, Tatyana A. Vetter, Nianyuan Huang, Reid Neinast, Lumariz Hernandez-Rosario, Dhanarajan Rajakumar, W. David Arnold, Kim L. McBride, Kevin M. Flanigan, Robert B. Weiss, Nicolas Wein
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Myotonic dystrophy type 1 (DM1) is the most common form of muscular dystrophy in adults and affects mainly the skeletal muscle, heart, and brain. DM1 is caused by a CTG repeat expansion in the 3′UTR region of the DMPK gene that sequesters musclebli
Externí odkaz:
https://doaj.org/article/64f77f1950614b9e88620a368751f95d
Autor:
Kelly A. Rich, Megan G. Pino, Mehmet E. Yalvac, Ashley Fox, Hallie Harris, Maria H.H. Balch, W. David Arnold, Stephen J. Kolb
Publikováno v:
Neurobiology of Disease, Vol 182, Iss , Pp 106148- (2023)
Kinesin family member 5A (KIF5A) is an essential, neuron-specific microtubule-associated motor protein responsible for the anterograde axonal transport of various cellular cargos. Loss of function variants in the N-terminal, microtubule-binding domai
Externí odkaz:
https://doaj.org/article/cda27b4962784d7c8318bfefea38a90e
Autor:
Jennifer M. Petrosino, Scott A. Hinger, Volha A. Golubeva, Juan M. Barajas, Lisa E. Dorn, Chitra C. Iyer, Hui-Lung Sun, W. David Arnold, Chuan He, Federica Accornero
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Muscle undergoes hypertrophy and atrophy in response to physiological stimuli or in pathological conditions, which is partially controlled through altered gene expression. Here the authors report that m6A methyltransferase METTL3 and mRNA m6A post-tr
Externí odkaz:
https://doaj.org/article/1a052b16c28446cb99698ffe0e5759b1
Autor:
Li Xu, Chen Zhang, Haiwen Li, Peipei Wang, Yandi Gao, Nahush A. Mokadam, Jianjie Ma, W. David Arnold, Renzhi Han
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Base editing is one approach used to correct mutations causing cause Duchenne muscular dystrophy (DMD), but limitations are in the requirement for a specific PAM motif and the large size beyond the packaging capacity of adeno-associated virus (AAV).
Externí odkaz:
https://doaj.org/article/e267fd77833f4da08de183661fa8161a
Autor:
Brian C. Clark, Dustin R. Grooms, Timothy Etheridge, Daniel J. Wilkinson, Shouan Zhu, W. David Arnold, Nathaniel J. Szewczyk
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/2e1f5d04c7864ae8a087289a382dddc4
Treatment preference among patients with spinal muscular atrophy (SMA): a discrete choice experiment
Autor:
Alisha Monnette, Er Chen, Dongzhe Hong, Alessandra Bazzano, Stacy Dixon, W. David Arnold, Lizheng Shi
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-13 (2021)
Abstract Objective To examine patient/caregiver preference for key attributes of treatments for spinal muscular atrophy (SMA). Background In the rapidly evolving SMA treatment landscape, it is critically important to understand how attributes of pote
Externí odkaz:
https://doaj.org/article/bdfd458a9bfe4ea7824349b8aca3d540
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105488- (2021)
Spinal muscular atrophy (SMA) is an autosomal recessive disease characterized by survival motor neuron (SMN) protein deficiency which results in motor neuron loss and muscle atrophy. SMA is caused by a mutation or deletion of the survival motor neuro
Externí odkaz:
https://doaj.org/article/94f018ebc9774928b368b6ccc95ccc71