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Novel amidines and analogues as promising agents against intracellular parasites: a systematic review

Autor: Andrew Hemphill, Karl A. Werbovetz, Maria de Nazaré Correia Soeiro, W. D. Wilson, D. W. Boykin, Michael Zhuo Wang

Publikováno v: Parasitology
Soeiro, M. N. C.; Werbovetz, K.; Boykin, D. W.; Wilson, W. D.; Wang, M. Z.; Hemphill, Andrew (2013). Novel amidines and analogues as promising agents against intracellular parasites: a systematic review. Parasitology, 140(8), pp. 929-951. Cambridge University Press 10.1017/S0031182013000292

SUMMARYParasitic protozoa comprise diverse aetiological agents responsible for important diseases in humans and animals including sleeping sickness, Chagas disease, leishmaniasis, malaria, toxoplasmosis and others. They are major causes of mortality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::206537cedaf84c22d806998c4c687576
http://doc.rero.ch/record/289385/files/S0031182013000292.pdf

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A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context

Autor: David W. Boykin, Pu Guo, W. D. Wilson, Ananya Paul

Publikováno v: Molecules
Molecules, Vol 24, Iss 5, p 946 (2019)

We review the preparation of new compounds with good solution and cell uptake properties that can selectively recognize mixed A·T and G·C bp sequences of DNA. Our underlying aim is to show that these new compounds provide important new biotechnolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d113ff0fd1e03a03fb7d2a5ec5db200
https://doi.org/10.3390/molecules24050946

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Induced Fit Conformational Changes of a 'Reversed Amidine' Heterocycle: Optimized Interactions in a DNA Minor Groove Complex

Autor: Christian Bailly, Manoj Munde, M.P.H. Lee, D. W. Boykin, W. D. Wilson, Yunpeng Liu, Reem K. Arafa, Stephen Neidle

Publikováno v: Journal of the American Chemical Society. 129:5688-5698

To better understand the molecular basis for recognition of the DNA minor groove by heterocyclic cations, a series of "reversed amidine" substituted heterocycles has been prepared. Amidine derivatives for targeting the minor groove have the amidine c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4c56058ebc2e9bdcffe5f4a3d65f36
https://doi.org/10.1021/ja069003n

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Targeting the Inverted CCAAT Box 2 in the Topoisomerase IIα Promoter by JH-37, an Imidazole−Pyrrole Polyamide Hairpin: Design, Synthesis, Molecular Biology, and Biophysical Studies

Autor: Cameron M. Howard, Binh Nguyen, Sarah M. Horick, Suzanna L. Bailey, Daniel Hochhauser, N. M. Le, James A. Henry, Moses Lee, Karen L. Buchmueller, Minal Kotecha, John A. Hartley, W. D. Wilson

Publikováno v: Biochemistry. 43:12249-12257

The topoisomerase IIalpha promoter is regulated through transcription factor interactions with five inverted CCAAT boxes (ICBs). In confluent cancer cells, binding of nuclear factor Y to ICB2 represses the expression of this gene, contributing to res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f216917b89fc1b5101a58f5be28add65
https://doi.org/10.1021/bi048785z

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Evaluation of the Influence of Compound Structure on Stacked-Dimer Formation in the DNA Minor Groove

Autor: Lei Wang, Christian Bailly, Carolina Carrasco, D. W. Boykin, Chad E. Stephens, Arvind Kumar, W. D. Wilson

Publikováno v: Biochemistry. 40:2511-2521

The Human Genome Project as well as sequencing of the genomes of other organisms offers a wealth of DNA targets for both therapeutic and diagnostic applications, and it is important to develop additional DNA binding motifs to fully exploit the potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b75ab91e5741c93ac6012eec7b7742af
https://doi.org/10.1021/bi002301r

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A Heterocyclic Inhibitor of the Rev−RRE Complex Binds to RRE as a Dimer

Autor: W. D. Wilson, Arvind Kumar, Tina M. Davis, D. W. Boykin, Ke Li, Christian Bailly

Publikováno v: Biochemistry. 40:1150-1158

As part of a search for organic compounds that selectively target RNA, we found that specific diphenylfuran derivatives, which are related to compounds that bind to the DNA minor groove, bind very strongly to RNA in a manner very sensitive to the str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3dae69c9634a14fcbe93fd12dd99ef6
https://doi.org/10.1021/bi002338b

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A thermodynamic and structural analysis of DNA minor-groove complex formation 1 1Edited by I. Tinoco

Autor: D. W. Boykin, Stephen Neidle, Daoyuan Ding, W. D. Wilson, Mazur S, Farial A. Tanious, Arvind Kumar, I.J. Simpson

Publikováno v: Journal of Molecular Biology. 300:321-337

As part of an effort to develop a better understanding of the structural and thermodynamic principles of DNA minor groove recognition, we have investigated complexes of three diphenylfuran dications with the d(CGCGAATTCGCG)2 duplex. The parent compou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61b88e1d14a9a10f8d013bcd356936b8
https://doi.org/10.1006/jmbi.2000.3869

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Targeting RNA with Small Molecules

Autor: Ke Li, W. D. Wilson

Publikováno v: Current Medicinal Chemistry. 7:73-98

Therapeutic targeting of RNA is not as well-developed as with DNA and proteins, and the many structures and functions of RNA suggest that it is an underutilized target. As with DNA, RNA has heterocyclic bases and base pairs with a highly anionic back

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8600cde087cc9c57c26e5a4d43e87772
https://doi.org/10.2174/0929867003375434

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2,4-Diphenyl Furan Diamidines as Novel Anti-Pneumocystis carinii Pneumonia Agents

Autor: Brenden C. Bender, David W. Boykin, F. A. Tanious, W D Wilson, J. E. Hall, Donald R. McCurdy, Iris Francesconi, R R Tidwell

Publikováno v: Journal of Medicinal Chemistry. 42:2260-2265

Dicationic 2,4-bis(4-amidinophenyl)furans 5-10 and 2, 4-bis(4-amidinophenyl)-3,5-dimethylfurans 14 and 15 have been synthesized. Thermal melting studies revealed high binding affinity of the compounds to poly(dA-dT) and to the duplex oligomer d(CGCGA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9bde90c5fc136d6903e08c73c4c6d86
https://doi.org/10.1021/jm990071c

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Upper layer currents in the western tropical North Atlantic (1989-1991)

Autor: Elizabeth Johns, Bernard Bourlès, Kevin D. Leaman, W. D. Wilson, Robert L. Molinari

Publikováno v: Journal of Geophysical Research: Oceans. 104:1361-1375

Shipboard acoustic Doppler current profiler (ADCP) measurements and hydrographic observations of temperature, salinity, and dissolved oxygen are used to examine the upper water column flow field in the North Brazil Current (NBC) retroflection region

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::44cfcc2d1813f2aee0f1c19536f94cbe
https://doi.org/10.1029/1998jc900025

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