Zobrazeno 1 - 10
of 59
pro vyhledávání: '"W D W Rees"'
Autor:
W. D. W. Rees, C. M. Brown
Publikováno v:
Alimentary Pharmacology & Therapeutics. 9:251-262
Reflux of gastric acid and pepsins into the lower oesophagus causes symptoms such as heartburn and nausea, and tissue injury leading to erosive oesophagitis and stricture formation. This article reviews the mechanisms involved in protecting the oesop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6b0333ba4b5dd35a76aad55bb11a3f5
https://doi.org/10.1111/j.1365-2036.1995.tb00379.x
https://doi.org/10.1111/j.1365-2036.1995.tb00379.x
Publikováno v:
Alimentary Pharmacology & Therapeutics. 11:907-912
Introduction: Oral NSAIDs cause acute gastric injury that resolves, despite continued administration, by a process known as adaptation. Little is known about the factors that influence this process. Methods: Sixty-two healthy volunteers were given a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f761b7cac5941b0c52c0b1440e6b05
https://doi.org/10.1046/j.1365-2036.1997.00222.x
https://doi.org/10.1046/j.1365-2036.1997.00222.x
Publikováno v:
Digestive Diseases and Sciences. 41:1583-1588
Our objective was to determine whether H. pylori influences gastric mucosal injury and adaptation caused by naproxen. Twenty-four healthy volunteers, 12 H. pylori-positive and 12 H. pylori-negative, were given a 28-day course of naproxen 500 mg twice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4563b536b6a04e31fb4d5f7c0b98c26c
https://doi.org/10.1007/bf02087904
https://doi.org/10.1007/bf02087904
Publikováno v:
Digestive Diseases and Sciences. 40:1642-1650
Esophageal secretion of HCO 3 − ions occurs in opossum and man and may contribute to mucosal defense. Using a perfusion technique, neuroregulatory influences on esophageal and salivary HCO 3 − secretion were investigated in 24 healthy human subje
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18cd21ba4910f2a3d6b57d56e105bbc1
https://doi.org/10.1007/bf02212684
https://doi.org/10.1007/bf02212684
Publikováno v:
Gut. 36:649-653
Recent human studies suggest that oesophageal HCO3- secretion, in conjunction with salivary HCO3- secretion and secondary oesophageal peristalsis, is important for the protection of oesophageal mucosa from refluxed gastric contents. This study evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eacf365e49fb4ff29a61759693e448d4
https://doi.org/10.1136/gut.36.5.649
https://doi.org/10.1136/gut.36.5.649
Autor:
W. D. W. Rees, C. J. Shorrock
Publikováno v:
Gut. 33:164-169
The effect of 28 days' continuous administration of oral indomethacin on gastroduodenal morphology, gastric mucosal blood flow, and gastric mucosal prostaglandin E2 (PGE2) metabolism in man was studied to define further the mechanisms of mucosal inju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::925deecf4b7499f7fe93d9d8a266077e
https://doi.org/10.1136/gut.33.2.164
https://doi.org/10.1136/gut.33.2.164
Autor:
W. D. W. Rees
Publikováno v:
Scandinavian Journal of Gastroenterology. 27:4-6
Sucralfate has a complex effect on the luminal and mucosal environment of the stomach and duodenum. Some of the actions are important in ulcer healing whilst others are important in preventing subsequent ulcer relapse. Although sucralfate has little
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::483ecef0d8b9982d4bd1351247b1e677
https://doi.org/10.3109/00365529209093222
https://doi.org/10.3109/00365529209093222
The aim of the study was to compare the effects of meloxicam and piroxicam on the gastroduodenal mucosa in healthy adults.Forty-four healthy volunteers were given a 28 day course of either meloxicam 15 mg, piroxicam 20 mg or placebo. Damage to the oe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f9317718971eec0defa87f950848d4
https://europepmc.org/articles/PMC1873665/
https://europepmc.org/articles/PMC1873665/
Autor:
W. D. W. Rees, G. R. Lipscomb
Publikováno v:
Alimentary pharmacologytherapeutics. 10(2)
INTRODUCTION Oral nonsteroidal anti-inflammatory drugs (NSAIDs) cause acute gastric mucosal injury but the relative importance of systemic and topical effect of NSAIDs to overall gastric damage remains uncertain. METHODS Twenty-four healthy volunteer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cffffa17b445b8d4beb897c5ca376be6
https://pubmed.ncbi.nlm.nih.gov/8730240
https://pubmed.ncbi.nlm.nih.gov/8730240
Publikováno v:
Alimentary pharmacologytherapeutics. 9(4)
SUMMARY Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) frequently cause damage to the gastroduodenal mucosa, principally by suppressing mucosal prostaglandin synthesis. However, such acute mucosal injury usually resolves, despite continued
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf5b9bdc4f7a7ca6cfe7130bf8de6d6d
https://pubmed.ncbi.nlm.nih.gov/8527613
https://pubmed.ncbi.nlm.nih.gov/8527613