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pro vyhledávání: '"W D, Willis"'
Autor:
W. D. Willis
The goal of this monograph is to provide an overview of current thought about spinal cord mechanisms for sensory processing. We hope that the book will be useful both to basic neuroscientists and to clinicians. So me historical aspects of the problem
Publikováno v:
Neuroscience. 122:237-245
Ionotropic glutamate receptors are ligand-gated ion channels that help mediate rapid excitatory neurotransmission in the CNS. alpha-Amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are critical for synaptic plasticity in central nocic
Autor:
W. D. Willis, J. Palecek
Publikováno v:
Pain. 104:501-507
Recent clinical studies have demonstrated that a midline lesion of the dorsal columns (DC, limited midline myelotomy) reduces pain of visceral origin in patients with pelvic cancer. Animal experiments showed that a DC lesion leads to decreased activa
Autor:
W. D. Willis, Jeff Bagust
Publikováno v:
Neuroscience Letters. 330:139-142
The effects of bath applied muscimol upon spontaneous and evoked antidromic activity recorded from lumbar dorsal roots was investigated in hemisected, isolated preparations of rat spinal cord. In magnesium free medium containing 0.1 microM 4-aminopyr
Autor:
W. D. Willis, Carl Y. Saab
Publikováno v:
Experimental Brain Research. 146:117-121
The cerebellum modulates different nociceptive phenomena and influences visceral functions. This study shows cerebellar modulation of an abdominal reflex elicited by a visceral noxious stimulus (colorectal distension, CRD). The intensity of the refle
Publikováno v:
Neuroscience Letters. 327:17-20
The cerebellum was recently proposed to play a role in cognition and sensation in addition to motor phenomena. We have shown that the cerebellum is involved in the processing of sensory nociceptive information. In this study, the activity of neurons
Publikováno v:
Classical and Quantum Gravity. 19:1745-1750
The success of the LISA project depends on the ability of the disturbance reduction system to shield the proof masses from all external forces and to maintain tight pointing requirements relative to the other two spacecrafts. μN-thrusters are requir
Publikováno v:
Pain. 94:47-58
Nitric oxide (NO) is believed to be an important messenger molecule in signal transduction pathways that enhance nociceptive transmission in the central nervous system (CNS). The role of nitric oxide synthase (NOS) I and II, which synthesize NO, in c
Publikováno v:
Neuroscience. 106:171-182
GABAergic neurons play an important role in the generation of primary afferent depolarization, which results in presynaptic inhibition and, if large enough, triggers dorsal root reflexes. Recent electrophysiological studies by our group have suggeste
Publikováno v:
Neuroscience. 96:351-357
The relationship between exogenous or endogenous nitric oxide and c-fos, an immediate-early gene which can further activate the production of other substances in the central nervous system, was investigated in this study. We found that Fos expression