Výsledky vyhledávání

Gene amplification and altered enzymes as mechanisms for the development of drug resistance

Autor: J R, Bertino, M D, Carman, H L, Weiner, A, Cashmore, B A, Moroson, S, Srimatkandada, J H, Schornagel, W D, Medina, S K, Dube

Publikováno v: Cancer treatment reports. 67(10)

Two known mechanisms by which neoplastic cells may become resistant to chemotherapeutic agents are reviewed, using methotrexate (MTX) resistance as a model. These mechanisms are an increased level of target enzyme, found in several instances to be a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::db57750d8bcdfdee737bd368011845d9
https://pubmed.ncbi.nlm.nih.gov/6354438

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Genetic transformation of murine bone marrow cells to methotrexate resistance

Autor: F, Carr, W D, Medina, S, Dube, J R, Bertino

Publikováno v: Blood. 62(1)

Genetic transformation of murine bone marrow stem cells to methotrexate resistance was achieved using a modified calcium phosphate-DNA coprecipitation procedure. Bone marrow cells were transformed by DNA derived from methotrexate-resistant mouse 3T6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::553a3d3d0e9f263b72a0cf578868dbc0
https://pubmed.ncbi.nlm.nih.gov/6574796

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Molecular and karyological analysis of methotrexate-resistant and -sensitive human leukemic CCRF-CEM cells

Autor: E, Mini, S, Srimatkandada, W D, Medina, B A, Moroson, M D, Carman, J R, Bertino

Publikováno v: Cancer research. 45(1)

A methotrexate-resistant subline, CCRF-CEM/R1, was selected stepwise from the human leukemic lymphoblast T-cell line, CCRF-CEM, and maintained in 0.2 microM methotrexate. The development of resistance to methotrexate (75-fold) was associated with a 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2fcf9469d078564a887c0d686d00e526
https://pubmed.ncbi.nlm.nih.gov/3855283

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Akademický článek

Evaluación cualitativa de extractos macerados con diferentes solventes para la extracción de glicoalcaloides y flavonoides de Dioscórea bulbifera en condiciones estándar obtenidos en los llanos orientales de Colombia.

Autor: Armenta, J. E.¹ jhon.armenta@unillanos.edu.co, Bejarano, D. A.¹ diego.bejarano.navas@unillanos.edu.co, López, L. G.¹ llopezm@unillanos.edu.co, Cruz, M. A.¹ maria.cruz@unillanos.edu.co

Publikováno v: Entre Ciencia e Ingeniería. jul-dic2020, Vol. 14 Issue 28, p59-65. 7p.

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