Zobrazeno 1 - 10 of 23 pro vyhledávání: '"W D, Matthews"'
1
α1-adrenoceptor-mediated vasoconstriction in vivo to enantiomers of SK&F 89748-A
Autor: Bmwm Timmermans, Mjmc Thoolen, Bob Wilffert, Jp Hieble, W D Matthews, H. N. Doods, Mj Mathy, Rm Demarinis, Pa Vanzwieten, A Dejonge
Publikováno v: European Journal of Pharmacology. 101:45-55
The pressor activity of the 1-enantiomer of SKF 89748-A, 1,2,3,4-tetrahydro-8-methoxy-5-(methylthio)-2-naphthalenamine, in pithed normotensive rats was found comparable with that of 1-phenylephrine. The d-enantiomer was half as potent. The log dose-p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::205bf0f61ed1649c4ae91ae7a7431e4a
https://doi.org/10.1016/0014-2999(84)90029-3
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2
N-[2-hydroxy-5-[2-(methylamino)ethyl]phenyl]methanesulfonamide. A potent agonist which releases intracellular calcium by activation of .alpha.1-adrenoceptors
Autor: Robert M. DeMarinis, K. F. Jim, W. D. Matthews, J. P. Hieble, P. G. Lavanchy
Publikováno v: Journal of Medicinal Chemistry. 28:245-248
N-[2-Hydroxy-5-[2-(methylamino)ethyl]phenyl]methanesulfonamide (SK&F 102652) has been prepared and characterized pharmacologically. It is a potent agonist with an EC50 of 25 nM at alpha 1-adrenoceptors as determined in the isolated perfused rabbit ea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b0f540220b2b225aa452185a5cfc21
https://doi.org/10.1021/jm00380a017
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3
Development of an affinity ligand for purification of .alpha.2-adrenoceptors from human platelet membranes
Autor: Robert J. Lefkowitz, J. Lafferty, R. M. DeMarinis, W. D. Matthews, A. J. Krog, D H Shah, J. P. Hieble, John W. Regan, Marc G. Caron, K. G. Holden
Publikováno v: Journal of Medicinal Chemistry. 27:918-921
Human platelets contain alpha 2-adrenoceptors which are negatively coupled to the enzyme adenylate cyclase. In order to better understand the interaction of this subtype of alpha receptor with this key enzyme, we have initiated a program to isolate a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea91d495bf5a44e85be0fb1e369b357
https://doi.org/10.1021/jm00373a018
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4
Selective alpha-2 adrenoceptor blockade by SKF 86466: in vitro characterization of receptor selectivity
Autor: J P, Hieble, R M, DeMarinis, P J, Fowler, W D, Matthews
Publikováno v: The Journal of pharmacology and experimental therapeutics. 236(1)
SKF 86466 (6-chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine) is a potent and selective antagonist at alpha-2 adrenoceptors. Prejunctional alpha-2 adrenoceptor antagonism can be demonstrated either by blockade of the alpha-2 adrenoceptor-mediate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::31ff5d52b8257b4801bc2aea707ade93
https://pubmed.ncbi.nlm.nih.gov/2867217
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6
Characterization of alpha adrenoceptors on vascular smooth muscle: electrophysiological differentiation in canine saphenous vein
Autor: W D, Matthews, G P, McCafferty, M, Grous
Publikováno v: The Journal of pharmacology and experimental therapeutics. 231(2)
The effects of selective alpha adrenoceptor agonists on resting transmembrane potential (Em) and contractile responses of vascular smooth muscle of the canine saphenous vein (CSV) were investigated using microelectrode and isometric tension recording
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b42cb9299b419c3943c48092e34af83d
https://pubmed.ncbi.nlm.nih.gov/6149307
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8
Role of receptor reserve in the inhibition of alpha-1 adrenoceptor-mediated pressor responses by calcium antagonists in the pithed rat
Autor: K F, Jim, R A, Macia, W D, Matthews
Publikováno v: The Journal of pharmacology and experimental therapeutics. 238(1)
The effect of the calcium channel antagonists nifedipine and FR 34235 on the vasopressor response to alpha-1 adrenoceptor stimulation in the pithed normotensive rat was investigated. The maximal pressor response elicited by the full alpha-1 adrenocep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4e04f1f332ae21bc5501168b47b2ff72
https://pubmed.ncbi.nlm.nih.gov/3014124
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9
Affinity chromatography of human platelet α2-adrenergic receptors
Autor: N. Barden, W. D. Matthews, M G Caron, A. J. Krog, R. M. DeMarinis, John W. Regan, J. P. Hieble, K. G. Holden, Robert J. Lefkowitz
Catecholamines, such as epinephrine, inhibit the enzyme adenylate cyclase (EC 4.6.1.1) via a specific receptor mechanism involving α 2 -adrenergic receptors. In order to facilitate purification of these inhibitory receptors we have prepared a highly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e29e498d4ccb92c50d49b8e2fe736d0
https://europepmc.org/articles/PMC347311/
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10
Actions of iontophoretic phenytoin and medazepam on hippocampal neurons
Autor: W D, Matthews, J D, Connor
Publikováno v: The Journal of pharmacology and experimental therapeutics. 201(3)
In rats anesthetized with methoxyflurane, phenytoin (DPH) and medazepam (MDZ) were administered iontophoretically to pyramidal and granule cells discharging spontaneously or being driven by acetylcholine or glutamic acid. The objectives were to deter
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a49ffb16c3666d2f693bc7b5fdca969d
https://pubmed.ncbi.nlm.nih.gov/16997
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