Zobrazeno 1 - 10
of 14
pro vyhledávání: '"W Clay Spencer"'
Autor:
W Clay Spencer, Rebecca McWhirter, Tyne Miller, Pnina Strasbourger, Owen Thompson, LaDeana W Hillier, Robert H Waterston, David M Miller
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112102 (2014)
The simple and well-described structure of the C. elegans nervous system offers an unprecedented opportunity to identify the genetic programs that define the connectivity and function of individual neurons and their circuits. A correspondingly precis
Externí odkaz:
https://doaj.org/article/33da9be713da4733ac6ab9fe7555e361
Publikováno v:
eLife. 11
Assembly of transcriptomes encoding unique neuronal identities requires selective accessibility of transcription factors to cis-regulatory sequences in nucleosome-embedded postmitotic chromatin. Yet, the mechanisms controlling postmitotic neuronal ch
Autor:
Meagan M. Kitt, Nobuko Tabuchi, W. Clay Spencer, Heath L. Robinson, Xinrui L. Zhang, Brent A. Eastman, Katherine J. Lobur, Jerry Silver, Lin Mei, Evan S. Deneris
Publikováno v:
Cell reports. 39(3)
Neurons must function for decades of life, but how these non-dividing cells are preserved is poorly understood. Using mouse serotonin (5-HT) neurons as a model, we report an adult-stage transcriptional program specialized to ensure the preservation o
Autor:
Douglas G. McMahon, W. Clay Spencer, LaTasha K Crawford, Benjamin D. Rood, Noah H. Green, Caryne Craige, Paul J. Gresch, Sheryl G. Beck, Evan S. Deneris, Steven C. Wyler
Publikováno v:
The Journal of Neuroscience. 36:1758-1774
Newborn neurons enter an extended maturation stage, during which they acquire excitability characteristics crucial for development of presynaptic and postsynaptic connectivity. In contrast to earlier specification programs, little is known about the
Autor:
W. Clay Spencer, Alexander Gottschalk, Cody J. Smith, David M. Miller, William R Schafer, Steven J. Husson, Elana Feingold-Link, Timothy D. O’Brien, Sayaka Hori, Marios Chatzigeorgiou, Shohei Mitani
Publikováno v:
Neuron. 79:266-280
SummarySensory neurons adopt distinct morphologies and functional modalities to mediate responses to specific stimuli. Transcription factors and their downstream effectors orchestrate this outcome but are incompletely defined. Here, we show that diff
Autor:
W. Clay Spencer, Joseph D. Watson, Byeong J. Cha, Cody J. Smith, Timothy D. O’Brien, Millet Treinin, Adi Albeg, David M. Miller
Publikováno v:
Developmental Biology. 345(1):18-33
Nociceptive neurons innervate the skin with complex dendritic arbors that respond to pain-evoking stimuli such as harsh mechanical force or extreme temperatures. Here we describe the structure and development of a model nociceptor, the PVD neuron of
Autor:
J. Andrew Hardaway, Peace Odiase, Sarah M. Sturgeon, Chelsea L. Snarrenberg, W. Clay Spencer, X.Z. Shawn Xu, Lucia Carvelli, Shannon L. Hardie, Daniel P. Bermingham, Randy D. Blakely, Zhaoyu Li, David M. Miller
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 35(25)
Glial cells play a critical role in shaping neuronal development, structure, and function. In a screen for Caenorhabditis elegans mutants that display dopamine (DA)-dependent, Swimming-Induced Paralysis (Swip), we identified a novel gene, swip-10, th
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Autor:
Kathie L. Watkins, Christian Widmer, Vipin T. Sreedharan, Joseph D. Watson, David M. Miller, Rebecca McWhirter, Georg Zeller, Sarah C. Petersen, Gunnar Rätsch, Susan Strome, Jeanyoung Jo, Stefan R. Henz, Stephen E Von Stetina, Lisa N. Petrella, W. Clay Spencer, Menachem Katz, Shai Shaham, Valerie Reinke
Publikováno v:
Genome research. 21(2)
The C. elegans genome has been completely sequenced, and the developmental anatomy of this model organism is described at single-cell resolution. Here we utilize strategies that exploit this precisely defined architecture to link gene expression to c
Autor:
Marios Chatzigeorgiou, Sungjae Yoo, Katie S. Kindt, Joseph D. Watson, W. Clay Spencer, Monica Driscoll, David M. Miller, Sun Wook Hwang, Wei Hsiang Lee, Millet Treinin, William R Schafer
Publikováno v:
Nature neuroscience
Summary Polymodal nociceptors detect noxious stimuli including harsh touch, toxic chemicals, and extremes of heat and cold. The molecular mechanisms by which nociceptors are able to sense multiple qualitatively distinct stimuli are not well-understoo